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NameNeutral amino acid transporter B(0)
Synonyms
  • ASCT2
  • ATB(0)
  • Baboon M7 virus receptor
  • M7V1
  • RD114/simian type D retrovirus receptor
  • RDR
  • RDRC
  • Sodium-dependent neutral amino acid transporter type 2
  • Solute carrier family 1 member 5
Gene NameSLC1A5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000471|Neutral amino acid transporter B(0)
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVV
AVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLD
PGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEV
LDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIV
FGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFA
RLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLM
MKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVT
ATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAG
LLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESV
M
Number of residues541
Molecular Weight56597.64
Theoretical pI5.14
GO Classification
Functions
  • sodium
  • virus receptor activity
  • L-glutamine transmembrane transporter activity
  • neutral amino acid transmembrane transporter activity
  • receptor activity
Processes
  • amino acid transport
  • transmembrane transport
  • glutamine transport
  • neutral amino acid transport
  • ion transport
Components
  • plasma membrane
  • Golgi apparatus
  • extracellular exosome
  • integral component of plasma membrane
  • melanosome
  • membrane
General FunctionVirus receptor activity
Specific FunctionSodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).
Pfam Domain Function
Transmembrane Regions53-73 99-119 133-153 225-245 266-286 306-326 336-356 377-397 399-419 426-446
GenBank Protein ID1478281
UniProtKB IDQ15758
UniProtKB Entry NameAAAT_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010024|Neutral amino acid transporter B(0) (SLC1A5)
ATGAACATCCTGGGCTTGGTAGTGTTTGCCATCGTCTTTGGTGTGGCGCTGCGGAAGCTG
GGGCCTGAAGGGGAGCTGCTTATCCGCTTCTTCAACTCCTTCAATGAGGCCACCATGGTT
CTGGTCTCCTGGATCATGTGGTACGCCCCTGTGGGCATCATGTTCCTGGTGGCTGGCAAG
ATCGTGGAGATGGAGGATGTGGGTTTACTCTTTGCCCGCCTTGGCAAGTACATTCTGTGC
TGCCTGCTGGGTCACGCCATCCATGGGCTCCTGGTACTGCCCCTCATCTACTTCCTCTTC
ACCCGCAAAAACCCCTACCGCTTCCTGTGGGGCATCGTGACGCCGCTGGCCACTGCCTTT
GGGACCTCTTCCAGTTCCGCCACGCTGCCGCTGATGATGAAGTGCGTGGAGGAGAATAAT
GGCGTGGCCAAGCACATCAGCCGTTTCATCCTGCCCATCGGCGCCACCGTCAACATGGAC
GGTGCCGCGCTCTTCCAGTGCGTGGCCGCAGTGTTCATTGCACAGCTCAGCCAGCAGTCC
TTGGACTTCGTAAAGATCATCACCATCCTGGTCACGGCCACAGCGTCCAGCGTGGGGGCA
GCGGGCATCCCTGCTGGAGGTGTCCTCACTCTGGCCATCATCCTCGAAGCAGTCAACCTC
CCGGTCGACCATATCTCCTTGATCCTGGCTGTGGACTGGCTAGTCGACCGGTCCTGTACC
GTCCTCAATGTAGAAGGTGACGCTCTGGGGGCAGGACTCCTCCAAAATTACGTGGACCGT
ACGGAGTCGAGAAGCACAGAGCCTGAGTTGATACAAGTGAAGAGTGAGCTGCCCCTGGAT
CCGCTGCCAGTCCCCACTGAGGAAGGAAACCCCCTCCTCAAACACTATCGGGGGCCCGCA
GGGGATGCCACGGTCGCCTCTGAGAAGGAATCAGTCATGTAA
GenBank Gene IDU53347
GeneCard IDNot Available
GenAtlas IDSLC1A5
HGNC IDHGNC:10943
Chromosome Location19
Locus19q13.3
References
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  2. Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD: The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2129-34. 10051606
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