T3DB: Cyclic nucleotide-gated olfactory channel

Name	Cyclic nucleotide-gated olfactory channel
Synonyms	CNCA CNCA1 CNCG2 CNG channel alpha-2 CNG-2 CNG2 Cyclic nucleotide-gated cation channel 2 Cyclic nucleotide-gated channel alpha-2
Gene Name	CNGA2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0017677\|Cyclic nucleotide-gated olfactory channel MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA ADEP
Number of residues	664
Molecular Weight	76047.505
Theoretical pI	Not Available
GO Classification	Functions voltage-gated potassium channel activity cGMP binding cAMP binding intracellular cGMP activated cation channel activity Processes phototransduction, visible light potassium ion transmembrane transport organelle organization regulation of membrane potential sensory perception of smell Components integral component of plasma membrane Golgi membrane ciliary membrane Golgi-associated vesicle membrane
General Function	Voltage-gated potassium channel activity
Specific Function	Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Pfam Domain Function	Ion_trans (PF00520 ) cNMP_binding (PF00027 ) CLZ (PF16526 )
Transmembrane Regions	139-159 172-192 225-245 275-295 351-371 454-474
GenBank Protein ID	Not Available
UniProtKB ID	Q16280
UniProtKB Entry Name	CNGA2_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0017678\|Cyclic nucleotide-gated olfactory channel (CNGA2) ATGACCGAAAAAACCAATGGTGTGAAGAGCTCCCCAGCCAATAATCACAACCATCATGCA CCTCCTGCCATCAAGGCCAATGGCAAAGATGACCACAGGACAAGCAGCAGGCCACACTCT GCAGCTGACGATGACACCTCCTCAGAACTGCAGAGGCTGGCAGACGTGGATGCCCCACAG CAGGGAAGGAGTGGCTTCCGCAGGATAGTTCGCCTGGTGGGGATCATCAGAGAATGGGCC AACAAGAATTTCCGAGAGGAGGAACCTAGGCCTGACTCATTCCTCGAGCGTTTTCGTGGG CCTGAACTCCAGACTGTGACCACACAGGAGGGGGATGGCAAAGGCGACAAGGATGGCGAG GACAAAGGCACCAAGAAGAAATTTGAACTATTTGTCTTGGACCCAGCTGGGGATTGGTAC TACTGCTGGCTATTTGTCATTGCCATGCCCGTCCTTTACAACTGGTGCCTGCTGGTGGCC AGAGCCTGCTTCAGTGACCTACAGAAAGGCTACTACCTGGTGTGGCTGGTGCTGGATTAT GTCTCAGATGTGGTCTACATTGCGGACCTCTTCATCCGATTGCGCACAGGTTTCCTGGAG CAGGGGCTGCTGGTCAAAGATACCAAGAAACTGCGAGACAACTACATCCACACCCTGCAG TTCAAGCTGGATGTGGCTTCCATCATCCCCACTGACCTGATCTATTTTGCTGTGGACATC CACAGCCCTGAGGTGCGCTTCAACCGCCTGCTGCACTTTGCCCGCATGTTTGAGTTCTTT GACCGGACAGAGACACGCACCAACTACCCTAACATCTTCCGCATCAGCAACCTTGTCCTC TACATCTTGGTCATCATCCACTGGAATGCCTGCATCTATTATGCCATCTCCAAATCCATA GGCTTTGGGGTCGACACCTGGGTTTACCCAAACATCACTGACCCTGAGTATGGCTACCTG GCTAGGGAATACATCTATTGCCTTTACTGGTCCACACTGACTCTCACTACCATTGGGGAG ACACCACCCCCTGTAAAGGATGAGGAGTACCTATTTGTCATCTTTGACTTCCTGATTGGC GTCCTCATCTTTGCCACCATCGTGGGAAATGTGGGCTCCATGATCTCCAACATGAATGCC ACCCGGGCAGAGTTCCAGGCTAAGATCGATGCCGTGAAACACTACATGCAGTTCCGAAAG GTCAGCAAGGGGATGGAAGCCAAGGTCATTAGGTGGTTTGACTACTTGTGGACCAATAAG AAGACAGTGGATGAGCGAGAAATTCTCAAGAATCTGCCAGCCAAGCTCAGGGCTGAGATA GCCATCAATGTCCACTTGTCCACACTCAAGAAAGTGCGCATCTTCCATGATTGTGAGGCT GGCCTGCTGGTAGAGCTGGTACTGAAACTCCGTCCTCAGGTCTTCAGTCCTGGGGATTAC ATTTGCCGCAAAGGGGACATCGGCAAGGAGATGTACATCATTAAGGAGGGCAAACTGGCA GTGGTGGCTGATGATGGTGTGACTCAGTATGCTCTGCTGTCGGCTGGAAGCTGCTTTGGC GAGATCAGTATCCTTAACATTAAGGGCAGTAAAATGGGCAATCGACGCACAGCTAATATC CGCAGCCTGGGCTACTCAGATCTCTTCTGCTTGTCCAAGGATGATCTTATGGAAGCTGTG ACTGAGTACCCTGATGCCAAGAAAGTCCTAGAAGAGAGGGGTCGGGAGATCCTCATGAAG GAGGGACTGCTGGATGAGAACGAAGTGGCAACCAGCATGGAGGTCGACGTGCAGGAGAAG CTAGGGCAGCTGGAGACCAACATGGAAACCTTGTACACTCGCTTTGGCCGCCTGCTGGCT GAGTACACGGGGGCCCAGCAGAAGCTCAAGCAGCGCATCACAGTTCTGGAAACCAAGATG AAACAGAACAATGAAGATGACTACCTGTCTGATGGGATGAACAGCCCTGAGCTGGCTGCT GCTGACGAGCCATAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:2149
Chromosome Location	X
Locus	Not Available
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