Dihydropyrimidinase-related protein 2

NameDihydropyrimidinase-related protein 2
Synonyms
  • Collapsin response mediator protein 2
  • CRMP-2
  • CRMP2
  • DRP-2
  • N2A3
  • ULIP-2
  • ULIP2
  • Unc-33-like phosphoprotein 2
Gene NameDPYSL2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009835|Dihydropyrimidinase-related protein 2
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA
HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF
DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ
IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI
TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA
FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE
RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI
SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK
RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS
LSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
Number of residues572
Molecular Weight62293.135
Theoretical pINot Available
GO Classification
Functions
  • dihydropyrimidinase activity
Processes
  • spinal cord development
  • positive regulation of glutamate secretion
  • nucleobase-containing compound metabolic process
  • signal transduction
  • response to drug
  • endocytosis
  • synaptic vesicle transport
  • olfactory bulb development
  • cytoskeleton organization
  • axon guidance
  • regulation of axon extension
  • nervous system development
  • response to amphetamine
  • response to cocaine
Components
  • mitochondrion
  • membrane
  • protein complex
  • neuronal cell body
  • cytoskeleton
  • terminal bouton
  • cytosol
  • extracellular exosome
  • myelin sheath
  • dendrite
  • growth cone
General FunctionDihydropyrimidinase activity
Specific FunctionPlays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ16555
UniProtKB Entry NameDPYL2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017843|Dihydropyrimidinase-related protein 2 (DPYSL2)
ATGGCCGAGAGAAAGCAATCCGGGAAGGCGGCAGAGGACGAAGAGGTCCCTGCTTTTTTT
AAAAACCTGGGCTCCGGCAGCCCCAAGCCCCGGCAGAAATTCTGTGGCATGTTCTGCCCG
GTGGAAGGGTCCTCGGAGAACAAGACCATCGACTTCGACTCGCTGTCGGTGGGCCGGGGC
TCGGGGCAGGTGGTGGCTCAGCAGCGGGACGTCGCCCACTTGGGCCCGGACCCGCAGCCG
CCGTACTCGCGGCAGGGCCGGCGCGCCGGCGGAGAGCCATCTGTTGAATCGGGCCGGAAG
GTGGAGATCCGGAGGGCCTCGGGCAAAGAAGCCCTGCAGAACATCAACGACCAGAGCGAT
CGTCTTCTGATCAAAGGAGGTAAAATTGTTAATGATGACCAGTCGTTCTATGCAGACATA
TACATGGAAGATGGGTTGATCAAGCAAATAGGAGAAAATCTGATTGTGCCAGGAGGAGTG
AAGACCATCGAGGCCCACTCCCGGATGGTGATCCCCGGAGGAATTGACGTCCACACTCGT
TTCCAGATGCCTGATCAGGGAATGACGTCTGCTGATGATTTCTTCCAAGGAACCAAGGCG
GCCCTGGCTGGGGGAACCACTATGATCATTGACCACGTTGTTCCTGAGCCTGGGACAAGC
CTGCTCGCTGCCTTTGACCAGTGGAGGGAATGGGCCGACAGCAAGTCCTGCTGTGACTAC
TCTCTGCATGTGGACATCAGTGAGTGGCATAAGGGCATCCAGGAGGAGATGGAAGCGCTT
GTGAAGGATCACGGGGTAAATTCCTTCCTCGTGTACATGGCTTTCAAAGATCGCTTCCAG
CTAACGGATTGCCAGATTTATGAAGTACTGAGTGTGATCCGGGATATTGGCGCCATAGCC
CAAGTCCACGCAGAAAATGGCGACATCATTGCAGAGGAGCAGCAGAGGATCCTGGATCTG
GGCATCACGGGCCCCGAGGGACATGTGCTGAGCCGACCTGAGGAGGTCGAGGCCGAAGCC
GTGAATCGTGCCATCACCATCGCCAACCAGACCAACTGCCCGCTGTATATCACCAAGGTG
ATGAGCAAAAGCTCTGCTGAGGTCATCGCCCAGGCACGGAAGAAGGGAACTGTGGTGTAT
GGCGAGCCCATCACTGCCAGCTTGGGAACGGACGGCTCCCATTACTGGAGCAAGAACTGG
GCCAAGGCTGCTGCCTTTGTCACCTCCCCACCCTTGAGCCCTGATCCAACCACTCCAGAC
TTTCTCAACTCCTTGCTGTCCTGTGGAGACCTCCAGGTCACGGGCAGTGCCCATTGCACG
TTTAACACTGCCCAGAAGGCTGTAGGAAAGGACAACTTCACCCTGATTCCGGAGGGCACC
AATGGCACTGAGGAGCGGATGTCCGTCATCTGGGACAAGGCTGTGGTCACTGGGAAGATG
GATGAGAACCAGTTTGTGGCTGTGACCAGCACCAATGCAGCCAAAGTCTTCAACCTTTAC
CCCCGGAAAGGCCGCATTGCTGTGGGATCCGATGCCGACCTGGTCATCTGGGACCCCGAC
AGCGTTAAAACCATCTCTGCCAAGACACACAACAGCTCTCTCGAGTACAACATCTTTGAA
GGCATGGAGTGCCGCGGCTCCCCACTGGTGGTCATCAGCCAGGGGAAGATTGTCCTGGAG
GACGGCACCCTGCATGTCACCGAAGGCTCTGGACGCTACATTCCCCGGAAGCCCTTCCCT
GATTTTGTTTACAAGCGTATCAAGGCAAGGAGCAGGCTGGCTGAGCTGAGAGGGGTTCCT
CGTGGCCTGTATGACGGACCTGTGTGTGAAGTGTCTGTGACGCCCAAGACAGTCACTCCA
GCCTCCTCGGCCAAGACGTCTCCTGCCAAGCAGCAGGCCCCACCTGTCCGGAACCTGCAC
CAGTCTGGATTCAGTTTGTCTGGTGCTCAGATTGATGACAACATTCCCCGCCGCACCACC
CAGCGTATCGTGGCGCCCCCCGGTGGCCGTGCCAACATCACCAGCCTGGGCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3014
Chromosome Location8
LocusNot Available
References
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