Hydroxyquinol 1,2-dioxygenase

NameHydroxyquinol 1,2-dioxygenase
Synonyms
  • 1,2-HQD
  • 1.13.11.37
Gene NamechqB
OrganismNocardioides simplex
Amino acid sequence
>lcl|BSEQ0012217|Hydroxyquinol 1,2-dioxygenase
MSTPVSAEQQAREQDLVERVLRSFDATADPRLKQVMQALTRHLHAFLREVRLTEAEWETG
IGFLTDAGHVTNERRQEFILLSDVLGASMQTIAMNNEAHGDATEATVFGPFFVEGSPRIE
SGGDIAGGAAGEPCWVEGTVTDTDGNPVPDARIEVWEADDDGFYDVQYDDDRTAARAHLL
SGPDGGYAFWAITPTPYPIPHDGPVGRMLAATGRSPMRASHLHFMVTAPGRRTLVTHIFV
EGDELLDRDSVFGVKDSLVKSFERQPAGAPTPGGREIDGPWSRVRFDIVLAPA
Number of residues293
Molecular Weight31966.33
Theoretical pI4.5
GO Classification
Functions
  • ferric iron binding
  • catechol 1,2-dioxygenase activity
  • hydroxyquinol 1,2-dioxygenase activity
Processes
  • beta-ketoadipate pathway
  • catechol-containing compound metabolic process
General FunctionHydroxyquinol 1,2-dioxygenase activity
Specific FunctionCatalyzes the ortho-cleavage of the aromatic ring of hydroxyquinol.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ5PXQ6
UniProtKB Entry NameCHQB_NOCSI
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0006199|882 bp
ATGAGCACGCCCGTCTCCGCCGAGCAGCAGGCCCGCGAGCAGGACCTGGTCGAGCGCGTG
CTGCGCTCCTTCGACGCCACCGCCGACCCGCGCCTGAAGCAGGTGATGCAGGCGCTGACC
CGGCACCTGCACGCCTTCCTGCGCGAGGTGCGGCTGACCGAGGCGGAGTGGGAGACCGGG
ATCGGCTTCCTGACCGACGCCGGTCACGTCACCAACGAGCGACGCCAGGAGTTCATCCTG
CTCTCCGACGTCCTCGGCGCGTCGATGCAGACGATCGCGATGAACAACGAGGCCCACGGC
GACGCCACCGAGGCCACCGTCTTCGGACCGTTCTTCGTCGAGGGGTCGCCGCGGATCGAG
TCCGGCGGTGACATCGCCGGTGGCGCGGCCGGCGAGCCGTGCTGGGTCGAGGGCACGGTC
ACCGACACCGACGGCAACCCCGTGCCCGATGCGCGGATCGAGGTGTGGGAGGCCGACGAC
GACGGCTTCTACGACGTCCAGTACGACGACGACCGCACCGCCGCGCGCGCCCACCTGCTC
AGCGGCCCGGACGGAGGCTATGCGTTCTGGGCGATCACGCCGACCCCCTACCCGATCCCC
CACGACGGGCCGGTCGGCCGGATGCTCGCCGCCACCGGCCGCTCCCCCATGCGCGCCTCG
CACCTGCACTTCATGGTCACCGCGCCCGGGCGGCGCACGTTGGTCACGCACATCTTCGTC
GAGGGCGACGAGCTGCTCGACCGCGACTCGGTGTTCGGCGTGAAGGACTCGCTTGTCAAG
AGCTTCGAGCGGCAGCCGGCCGGCGCGCCCACTCCCGGCGGCCGCGAGATCGACGGCCCC
TGGTCGCGGGTGCGCTTCGACATCGTCCTCGCTCCCGCCTGA
GenBank Gene IDAY822041
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Ferraroni M, Seifert J, Travkin VM, Thiel M, Kaschabek S, Scozzafava A, Golovleva L, Schlomann M, Briganti F: Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. J Biol Chem. 2005 Jun 3;280(22):21144-54. Epub 2005 Mar 16. 15772073
  2. Travkin VM, Jadan AP, Briganti F, Scozzafava A, Golovleva LA: Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T. FEBS Lett. 1997 Apr 21;407(1):69-72. 9141483