NameProtein-arginine deiminase type-6
Synonyms
  • 3.5.3.15
  • hPADVI
  • PAD6
  • Peptidyl arginine deiminase-like protein
  • Peptidylarginine deiminase VI
  • Protein-arginine deiminase type VI
Gene NamePADI6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011665|Protein-arginine deiminase type-6
MVSVEGRAMSFQSIIHLSLDSPVHAVCVLGTEICLDLSGCAPQKCQCFTIHGSGRVLIDV
ANTVISEKEDATIWWPLSDPTYATVKMTSPSPSVDADKVSVTYYGPNEDAPVGTAVLYLT
GIEVSLEVDIYRNGQVEMSSDKQAKKKWIWGPSGWGAILLVNCNPADVGQQLEDKKTKKV
IFSEEITNLSQMTLNVQGPSCILKKYRLVLHTSKEESKKARVYWPQKDNSSTFELVLGPD
QHAYTLALLGNHLKETFYVEAIAFPSAEFSGLISYSVSLVEESQDPSIPETVLYKDTVVF
RVAPCVFIPCTQVPLEVYLCRELQLQGFVDTVTKLSEKSNSQVASVYEDPNRLGRWLQDE
MAFCYTQAPHKTTSLILDTPQAADLDEFPMKYSLSPGIGYMIQDTEDHKVASMDSIGNLM
VSPPVKVQGKEYPLGRVLIGSSFYPSAEGRAMSKTLRDFLYAQQVQAPVELYSDWLMTGH
VDEFMCFIPTDDKNEGKKGFLLLLASPSACYKLFREKQKEGYGDALLFDELRADQLLSNG
REAKTIDQLLADESLKKQNEYVEKCIHLNRDILKTELGLVEQDIIEIPQLFCLEKLTNIP
SDQQPKRSFARPYFPDLLRMIVMGKNLGIPKPFGPQIKGTCCLEEKICCLLEPLGFKCTF
INDFDCYLTEVGDICACANIRRVPFAFKWWKMVP
Number of residues694
Molecular Weight77726.735
Theoretical pI4.9
GO Classification
Functions
  • calcium ion binding
  • protein-arginine deiminase activity
Processes
  • cytoskeleton organization
  • cytoplasm organization
  • protein citrullination
  • regulation of translation by machinery localization
Components
  • cytoplasm
  • nucleus
  • intermediate filament cytoskeleton
General FunctionProtein-arginine deiminase activity
Specific FunctionCatalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID40068449
UniProtKB IDQ6TGC4
UniProtKB Entry NamePADI6_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011666|Protein-arginine deiminase type-6 (PADI6)
ATGGTCAGCGTGGAGGGCCGAGCCATGTCCTTCCAGAGTATCATCCACCTGTCCCTGGAC
AGCCCTGTCCATGCCGTTTGTGTGTTGGGCACAGAAATCTGCTTGGATCTCAGCGGGTGT
GCCCCCCAGAAGTGCCAGTGCTTCACCATCCATGGCTCTGGGAGGGTCTTGATCGATGTG
GCCAACACGGTGATTTCTGAGAAGGAGGACGCCACCATCTGGTGGCCCCTGTCTGATCCC
ACGTACGCCACAGTGAAGATGACATCGCCCAGCCCTTCCGTGGATGCGGATAAGGTCTCG
GTCACATACTATGGGCCCAACGAGGATGCCCCCGTGGGCACAGCTGTGCTGTACCTCACT
GGCATTGAGGTCTCTCTAGAGGTAGACATCTACCGCAATGGGCAAGTTGAGATGTCAAGT
GACAAACAGGCTAAGAAAAAATGGATCTGGGGTCCCAGCGGTTGGGGTGCCATCCTGCTT
GTGAATTGCAACCCTGCTGATGTGGGCCAGCAACTTGAGGACAAGAAAACCAAGAAAGTG
ATCTTTTCAGAGGAAATAACGAATCTGTCCCAGATGACTCTGAATGTCCAAGGCCCCAGC
TGTATCTTAAAGAAATATCGGCTAGTCCTCCATACCTCCAAGGAAGAGTCGAAGAAGGCG
AGAGTCTACTGGCCCCAAAAAGACAACTCCAGTACCTTTGAGTTGGTGCTGGGGCCCGAC
CAGCACGCCTATACCTTGGCCCTCCTCGGGAACCACTTGAAGGAGACTTTCTACGTTGAA
GCTATAGCATTCCCATCTGCCGAATTCTCAGGCCTCATCTCCTACTCTGTGTCCCTGGTG
GAGGAGTCTCAAGACCCGTCAATTCCAGAGACTGTGCTGTACAAAGACACGGTGGTGTTC
CGGGTGGCTCCCTGTGTCTTCATTCCCTGTACCCAGGTGCCTCTGGAGGTTTACCTGTGC
AGGGAGCTGCAGCTGCAGGGTTTTGTGGACACAGTGACGAAGCTGAGTGAGAAGAGCAAC
AGCCAGGTGGCATCTGTCTATGAGGACCCCAACCGCCTGGGCAGGTGGCTCCAGGATGAG
ATGGCCTTCTGCTACACCCAGGCTCCCCACAAGACAACGTCCTTGATCCTCGACACACCT
CAGGCCGCCGATCTCGATGAGTTCCCCATGAAGTACTCACTGAGCCCTGGTATTGGCTAC
ATGATCCAGGACACTGAGGACCATAAAGTGGCCAGCATGGATTCCATTGGGAACCTGATG
GTGTCCCCACCTGTCAAGGTCCAAGGGAAAGAGTACCCGCTGGGCAGAGTCCTCATTGGC
AGCAGCTTTTACCCCAGCGCAGAGGGCCGGGCCATGAGTAAGACCCTCCGAGACTTCCTC
TATGCCCAGCAGGTCCAAGCGCCGGTGGAGCTCTACTCAGATTGGCTAATGACTGGCCAC
GTGGATGAGTTCATGTGCTTCATCCCCACAGATGACAAGAATGAGGGCAAAAAGGGCTTC
CTGCTGCTCCTGGCCAGCCCCAGTGCCTGCTATAAACTGTTCCGAGAGAAACAGAAGGAA
GGCTATGGCGACGCTCTTCTGTTTGATGAGCTTAGAGCAGATCAGCTCCTGTCTAATGGA
AGGGAAGCCAAAACCATCGACCAACTTCTGGCTGATGAAAGCCTGAAGAAGCAGAATGAA
TACGTGGAGAAGTGCATTCACCTGAACCGTGACATCCTGAAGACGGAGCTGGGCCTGGTG
GAACAGGACATCATCGAGATTCCCCAGCTGTTCTGCTTGGAGAAGCTGACTAACATCCCC
TCTGACCAGCAGCCCAAGAGGTCCTTTGCGAGGCCATACTTCCCTGACCTGTTGCGGATG
ATTGTGATGGGCAAGAACCTGGGGATCCCCAAGCCTTTTGGGCCCCAAATCAAGGGGACC
TGCTGCCTGGAAGAAAAGATTTGCTGCTTGCTGGAGCCCCTGGGCTTCAAGTGCACCTTC
ATCAATGACTTTGACTGTTACCTGACAGAGGTCGGAGACATCTGTGCCTGTGCCAACATC
CGCCGGGTGCCCTTTGCCTTCAAATGGTGGAAGATGGTACCTTAG
GenBank Gene IDAY422079
GeneCard IDNot Available
GenAtlas IDPADI6
HGNC IDHGNC:20449
Chromosome Location1
Locus1p36.13
References
  1. Zhang J, Dai J, Zhao E, Lin Y, Zeng L, Chen J, Zheng H, Wang Y, Li X, Ying K, Xie Y, Mao Y: cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI. Acta Biochim Pol. 2004;51(4):1051-8. 15625577
  2. Chavanas S, Mechin MC, Takahara H, Kawada A, Nachat R, Serre G, Simon M: Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Gene. 2004 Apr 14;330:19-27. 15087120
  3. Rose R, Rose M, Ottmann C: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J Struct Biol. 2012 Oct;180(1):65-72. doi: 10.1016/j.jsb.2012.05.010. Epub 2012 May 24. 22634725