Histone H3.2

NameHistone H3.2
Synonyms
  • H3F2
  • H3FM
  • Histone H3/m
  • Histone H3/o
Gene NameHIST2H3A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013430|Histone H3.2
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA
Number of residues136
Molecular Weight15387.865
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • histone binding
Processes
  • DNA methylation on cytosine
  • negative regulation of gene expression, epigenetic
  • regulation of gene expression, epigenetic
  • gene silencing by RNA
  • chromatin silencing at rDNA
  • blood coagulation
  • nucleosome assembly
  • small GTPase mediated signal transduction
  • gene expression
  • cellular protein metabolic process
Components
  • nucleosome
  • extracellular region
  • nucleus
  • extracellular exosome
  • nucleoplasm
General FunctionHistone binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ71DI3
UniProtKB Entry NameH32_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013431|Histone H3.2 (HIST2H3A)
ATGGCCCGTACTAAGCAGACTGCTCGCAAGTCGACCGGCGGCAAGGCCCCGAGGAAGCAG
CTGGCCACCAAGGCGGCCCGCAAGAGCGCGCCGGCCACGGGCGGGGTGAAGAAGCCGCAC
CGCTACCGGCCCGGCACCGTAGCCCTGCGGGAGATCCGGCGCTACCAGAAGTCCACGGAG
CTGCTGATCCGCAAGCTGCCCTTCCAGCGGCTGGTACGCGAGATCGCGCAGGACTTTAAG
ACGGACCTGCGCTTCCAGAGCTCGGCCGTGATGGCGCTGCAGGAGGCCAGCGAGGCCTAC
CTGGTGGGGCTGTTCGAAGACACGAACCTGTGCGCCATCCACGCCAAGCGCGTGACCATT
ATGCCCAAGGACATCCAGCTGGCCCGCCGCATCCGTGGAGAGCGGGCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:20505
Chromosome Location1
LocusNot Available
References
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