Scavenger receptor class B member 1

NameScavenger receptor class B member 1
Synonyms
  • CD36 and LIMPII analogous 1
  • CD36 antigen-like 1
  • CD36L1
  • CLA-1
  • CLA1
  • Collagen type I receptor, thrombospondin receptor-like 1
  • SR-BI
  • SRB1
Gene NameSCARB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000377|Scavenger receptor class B member 1
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIP
IPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQ
FQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIM
WGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGL
SKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYR
FVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTG
LHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESG
AMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSH
SLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLE
GLGPSLGGGTGS
Number of residues552
Molecular Weight60877.385
Theoretical pI8.31
GO Classification
Functions
  • virus receptor activity
  • apolipoprotein A-I binding
  • apolipoprotein binding
  • transporter activity
  • 1-phosphatidylinositol binding
  • high-density lipoprotein particle receptor activity
  • lipopolysaccharide binding
  • lipopolysaccharide receptor activity
  • low-density lipoprotein particle binding
  • phosphatidylserine binding
Processes
  • regulation of phosphatidylcholine catabolic process
  • adhesion of symbiont to host
  • triglyceride homeostasis
  • cholesterol import
  • detection of lipopolysaccharide
  • cholesterol efflux
  • high-density lipoprotein particle clearance
  • cholesterol homeostasis
  • lipoprotein metabolic process
  • high-density lipoprotein particle remodeling
  • reverse cholesterol transport
  • lipopolysaccharide transport
  • vitamin transmembrane transport
  • cell adhesion
  • lipopolysaccharide-mediated signaling pathway
  • low-density lipoprotein particle clearance
  • phospholipid transport
  • positive regulation of cholesterol storage
  • small molecule metabolic process
  • positive regulation of endothelial cell migration
  • positive regulation of nitric-oxide synthase activity
  • receptor-mediated endocytosis
  • positive regulation of triglyceride biosynthetic process
  • recognition of apoptotic cell
  • wound healing
  • regulation of phagocytosis
Components
  • caveola
  • endocytic vesicle membrane
  • plasma membrane
  • lysosomal membrane
  • cell surface
  • integral component of membrane
  • extracellular exosome
  • intracellular membrane-bounded organelle
General FunctionVirus receptor activity
Specific FunctionReceptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes.
Pfam Domain Function
Transmembrane Regions12-32 444-464
GenBank Protein ID397607
UniProtKB IDQ8WTV0
UniProtKB Entry NameSCRB1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0009993|Scavenger receptor class B member 1 (SCARB1)
ATGGGCTGCTCCGCCAAAGCGCGCTGGGCTGCCGGGGCGCTGGGCGTCGCGGGGCTACTG
TGCGCTGTGCTGGGCGCTGTCATGATCGTGATGGTGCCGTCGCTCATCAAGCAGCAGGTC
CTTAAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAACATGTGGAAGGAGATCCCT
ATCCCCTTCTATCTCTCCGTCTACTTCTTTGACGTCATGAACCCCAGCGAGATCCTGAAG
GGCGAGAAGCCGCAGGTGCGGGAGCGCGGGCCCTACGTGTACAGGGAGTTCAGGCACAAA
AGCAACATCACCTTCAACAACAACGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAG
TTCCAGCCCTCCAAGTCCCACGGCTCGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGGGTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAGCTCATCATGACC
TTGGCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGTGAGATCATG
TGGGGCTACAAGGACCCCCTTGTGAATCTCATCAACAAGTACTTTCCAGGCATGTTCCCC
TTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTCTTCACG
GTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTGGAACGGGCTG
AGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATGGAACTTCTGGGCAA
ATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCTACAGCCCGGAGGCCTGC
CGATCCATGAAGCTAATGTACAAGGAGTCAGGGGTGTTTGAAGGCATCCCCACCTATCGC
TTCGTGGCTCCCAAAACCCTGTTTGCCAACGGGTCCATCTACCCACCCAACGAAGGCTTC
TGCCCGTGCCTGGAGTCTGGAATTCAGAACGTCAGCACCTGCAGGTTCAGTGCCCCCTTG
TTTCTCTCCCATCCTCACTTCCTCAACGCTGACCCGGTTCTGGCAGAAGCGGTGACTGGC
CTGCACCCTAACCAGGAGGCACACTCCTTGTTCCTGGACATCCACCCGGTCACGGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTACATGAAATCTGTCGCAGGCATT
GGACAAACTGGGAAGATTGAGCCTGTGGTCCTGCCGCTGCTCTGGTTTGCAGAGAGCGGG
GCCATGGAGGGGGAGACTCTTCACACATTCTACACTCAGCTGGTGTTGATGCCCAAGGTG
ATGCACTATGCCCAGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTC
ATCTGCCAAATCCGGAGCCAAGGTCCTGAGGACACCGTGAGCCAGCCAGGCCTGGCCGCT
GGGCCTGACCGGCCCCCCAGCCCCTACACCCCGCTTCTCCCGGACTCTCCCAGCGGACAG
CCCCCCAGCCCCACAGCCTGA
GenBank Gene IDZ22555
GeneCard IDNot Available
GenAtlas IDSCARB1
HGNC IDHGNC:1664
Chromosome Location12
Locus12q24.31
References
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