NameSodium/iodide cotransporter
Synonyms
  • Na(+)/I(-) cotransporter
  • Na(+)/I(-) symporter
  • NIS
  • Sodium-iodide symporter
  • Solute carrier family 5 member 5
Gene NameSLC5A5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013526|Sodium/iodide cotransporter
MEAVETGERPTFGAWDYGVFALMLLVSTGIGLWVGLARGGQRSAEDFFTGGRRLAALPVG
LSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSVLTALLFMPVFYRLGLTSTYEY
LEMRFSRAVRLCGTLQYIVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTFYTA
VGGMKAVVWTDVFQVVVMLSGFWVVLARGVMLVGGPRQVLTLAQNHSRINLMDFNPDPRS
RYTFWTFVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLINQVGLFLIVSSAACCG
IVMFVFYTDCDPLLLGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSIN
AMAAVTVEDLIKPRLRSLAPRKLVIISKGLSLIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFILGMFLPACNTPGVLAGLGAGLALSLWVALGATLYPPSEQTMRVLPSSA
ARCVALSVNASGLLDPALLPANDSSRAPSSGMDASRPALADSFYAISYLYYGALGTLTTV
LCGALISCLTGPTKRSTLAPGLLWWDLARQTASVAPKEEVAILDDNLVKGPEELPTGNKK
PPGFLPTNEDRLFFLGQKELEGAGSWTPCVGHDGGRDQQETNL
Number of residues643
Molecular Weight68665.63
Theoretical pINot Available
GO Classification
Functions
  • iodide transmembrane transporter activity
  • sodium
Processes
  • cellular response to gonadotropin stimulus
  • cellular response to cAMP
  • thyroid hormone generation
  • iodide transport
  • transport
  • ion transport
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • transmembrane transport
Components
  • extracellular vesicle
  • nucleus
  • plasma membrane
  • integral component of membrane
  • extracellular exosome
General FunctionSodium:iodide symporter activity
Specific FunctionMediates iodide uptake in the thyroid gland.
Pfam Domain Function
Transmembrane Regions17-37 54-74 89-109 137-157 164-184 187-207 242-262 287-307 327-347 392-412 417-437 445-465 526-546
GenBank Protein IDNot Available
UniProtKB IDQ92911
UniProtKB Entry NameSC5A5_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013527|Sodium/iodide cotransporter (SLC5A5)
ATGGAGGCCGTGGAGACCGGGGAACGGCCCACCTTCGGAGCCTGGGACTACGGGGTCTTT
GCCCTCATGCTCCTGGTGTCCACTGGCATCGGGCTGTGGGTCGGGCTGGCTCGGGGCGGG
CAGCGCAGCGCTGAGGACTTCTTCACCGGGGGCCGGCGCCTGGCGGCCCTGCCCGTGGGC
CTGTCGCTGTCTGCCAGCTTCATGTCGGCCGTGCAGGTGCTGGGCGTGCCGTCGGAGGCC
TATCGCTATGGCCTCAAGTTCCTCTGGATGTGCCTGGGCCAGCTTCTGAACTCGGTCCTC
ACCGCCCTGCTCTTCATGCCCGTCTTCTACCGCCTGGGCCTCACCAGCACCTACGAGTAC
CTGGAGATGCGCTTCAGCCGCGCAGTGCGGCTCTGCGGGACTTTGCAGTACATTGTAGCC
ACGATGCTGTACACCGGCATCGTAATCTACGCACCGGCCCTCATCCTGAACCAAGTGACC
GGGCTGGACATCTGGGCGTCGCTCCTGTCCACCGGAATTATCTGCACCTTCTACACGGCT
GTGGGCGGCATGAAGGCTGTGGTCTGGACTGATGTGTTCCAGGTCGTGGTGATGCTAAGT
GGCTTCTGGGTTGTCCTGGCACGCGGTGTCATGCTTGTGGGCGGGCCCCGCCAGGTGCTC
ACGCTGGCCCAGAACCACTCCCGGATCAACCTCATGGACTTTAACCCTGACCCGAGGAGC
CGCTATACATTCTGGACTTTTGTGGTGGGTGGCACGTTGGTGTGGCTCTCCATGTATGGC
GTGAACCAGGCGCAGGTGCAGCGCTACGTGGCTTGCCGCACAGAGAAGCAGGCCAAGCTG
GCCCTGCTCATCAACCAGGTCGGCCTGTTCCTGATCGTGTCCAGCGCTGCCTGCTGTGGC
ATCGTCATGTTTGTGTTCTACACTGACTGCGACCCTCTCCTCCTGGGGCGCATCTCTGCC
CCAGACCAGTACATGCCTCTGCTGGTGCTGGACATCTTCGAAGATCTGCCTGGAGTCCCC
GGGCTTTTCCTGGCCTGTGCTTACAGTGGCACCCTCAGCACAGCATCCACCAGCATCAAT
GCTATGGCTGCAGTCACTGTAGAAGACCTCATCAAACCTCGGCTGCGGAGCCTGGCACCC
AGGAAACTCGTGATTATCTCCAAGGGGCTCTCACTCATCTACGGATCGGCCTGTCTCACC
GTGGCAGCCCTGTCCTCACTGCTCGGAGGAGGTGTCCTTCAGGGCTCCTTCACCGTCATG
GGAGTCATCAGCGGCCCCCTGCTGGGAGCCTTCATCTTGGGAATGTTCCTGCCGGCCTGC
AACACACCGGGCGTCCTCGCGGGACTAGGCGCGGGCTTGGCGCTGTCGCTGTGGGTGGCC
TTGGGCGCCACGCTGTACCCACCCAGCGAGCAGACCATGAGGGTCCTGCCATCGTCGGCT
GCCCGCTGCGTGGCTCTCTCAGTCAACGCCTCTGGCCTCCTGGACCCGGCTCTCCTCCCT
GCTAACGACTCCAGCAGGGCCCCCAGCTCAGGAATGGACGCCAGCCGACCCGCCTTAGCT
GACAGCTTCTATGCCATCTCCTATCTCTATTACGGTGCCCTGGGCACGCTGACCACTGTG
CTGTGCGGAGCCCTCATCAGCTGCCTGACAGGCCCCACCAAGCGCAGCACCCTGGCCCCG
GGATTGTTGTGGTGGGACCTCGCACGGCAGACAGCATCAGTGGCCCCCAAGGAAGAAGTG
GCCATCCTGGATGACAACTTGGTCAAGGGTCCTGAAGAACTCCCCACTGGAAACAAGAAG
CCCCCTGGCTTCCTGCCCACCAATGAGGATCGTCTGTTTTTCTTGGGGCAGAAGGAGCTG
GAGGGGGCTGGCTCTTGGACCCCCTGTGTTGGACATGATGGTGGTCGAGACCAGCAGGAG
ACAAACCTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11040
Chromosome Location19
LocusNot Available
References
  1. Smanik PA, Liu Q, Furminger TL, Ryu K, Xing S, Mazzaferri EL, Jhiang SM: Cloning of the human sodium lodide symporter. Biochem Biophys Res Commun. 1996 Sep 13;226(2):339-45. 8806637
  2. Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, Onaya T: Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab. 1997 Oct;82(10):3331-6. 9329364
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  5. Fujiwara H, Tatsumi K, Miki K, Harada T, Miyai K, Takai S, Amino N: Congenital hypothyroidism caused by a mutation in the Na+/I- symporter. Nat Genet. 1997 Jun;16(2):124-5. 9171822
  6. Kosugi S, Inoue S, Matsuda A, Jhiang SM: Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients. J Clin Endocrinol Metab. 1998 Sep;83(9):3373-6. 9745458
  7. Pohlenz J, Rosenthal IM, Weiss RE, Jhiang SM, Burant C, Refetoff S: Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site. J Clin Invest. 1998 Mar 1;101(5):1028-35. 9486973
  8. Kosugi S, Bhayana S, Dean HJ: A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. J Clin Endocrinol Metab. 1999 Sep;84(9):3248-53. 10487695