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NameProtein tyrosine phosphatase type IVA 1
Synonyms
  • 3.1.3.48
  • PRL-1
  • PRL1
  • Protein-tyrosine phosphatase 4a1
  • Protein-tyrosine phosphatase of regenerating liver 1
  • PTP(CAAXI)
  • PTPCAAX1
Gene NamePTP4A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013550|Protein tyrosine phosphatase type IVA 1
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK
EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI
EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
Number of residues173
Molecular Weight19814.93
Theoretical pINot Available
GO Classification
Functions
  • protein tyrosine phosphatase activity
  • protein tyrosine/serine/threonine phosphatase activity
Processes
  • positive regulation of cell migration
  • multicellular organismal development
  • peptidyl-tyrosine dephosphorylation
  • cell cycle
Components
  • extracellular exosome
  • early endosome
  • cytoplasmic side of plasma membrane
  • spindle
  • cytoplasm
  • nucleus
  • endoplasmic reticulum
General FunctionProtein tyrosine/serine/threonine phosphatase activity
Specific FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ93096
UniProtKB Entry NameTP4A1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013551|Protein tyrosine phosphatase type IVA 1 (PTP4A1)
ATGGCTCGAATGAACCGCCCAGCTCCTGTGGAAGTCACATACAAGAACATGAGATTTCTT
ATTACACACAATCCAACCAATGCGACCTTAAACAAATTTATAGAGGAACTTAAGAAGTAT
GGAGTTACCACAATAGTAAGAGTATGTGAAGCAACTTATGACACTACTCTTGTGGAGAAA
GAAGGTATCCATGTTCTTGATTGGCCTTTTGATGATGGTGCACCACCATCCAACCAGATT
GTTGATGACTGGTTAAGTCTTGTGAAAATTAAGTTTCGTGAAGAACCTGGTTGTTGTATT
GCTGTTCATTGCGTTGCAGGCCTTGGGAGAGCTCCAGTACTTGTTGCCCTAGCATTAATT
GAAGGTGGAATGAAATACGAAGATGCAGTACAATTCATAAGACAAAAGCGGCGTGGAGCT
TTTAACAGCAAGCAACTTCTGTATTTGGAGAAGTATCGTCCTAAAATGCGGCTGCGTTTC
AAAGATTCCAACGGTCATAGAAACAACTGTTGCATTCAATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9634
Chromosome Location6
LocusNot Available
References
  1. Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, Crowell PL, Crowell DN: Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. Cancer Lett. 1996 Dec 20;110(1-2):49-55. 9018080
  2. Peng Y, Genin A, Spinner NB, Diamond RH, Taub R: The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer. J Biol Chem. 1998 Jul 3;273(27):17286-95. 9642300
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