Bacterioferritin

NameBacterioferritin
Synonyms
  • 1.16.3.1
  • BFR
Gene Namebfr
OrganismDesulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Amino acid sequence
>lcl|BSEQ0011219|Bacterioferritin
MAGNREDRKAKVIEVLNKARAMELHAIHQYMNQHYSLDDMDYGELAANMKLIAIDEMRHA
ENFAERIKELGGEPTTQKEGKVVTGQAVPVIYESDADQEDATIEAYSQFLKVCKEQGDIV
TARLFERIIEEEQAHLTYYENIGSHIKNLGDTYLAKIAGTPSSTGTASKGFVTATPAAE
Number of residues179
Molecular Weight19881.14
Theoretical pI4.74
GO Classification
Functions
  • ferroxidase activity
  • ferric iron binding
Processes
  • intracellular sequestering of iron ion
  • iron ion transport
Components
  • cell
General FunctionFerroxidase activity
Specific FunctionIron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID14326006
UniProtKB IDQ93PP9
UniProtKB Entry NameBFR_DESDA
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0011220|Bacterioferritin (bfr)
ATGGCTGGAAATAGAGAAGACCGCAAGGCCAAGGTCATCGAGGTTCTCAACAAGGCTCGC
GCCATGGAGCTGCACGCCATCCACCAATACATGAACCAGCACTATAGCCTGGATGACATG
GACTATGGTGAGCTTGCCGCCAACATGAAGCTTATTGCCATCGACGAGATGCGCCATGCG
GAAAACTTCGCCGAGCGTATCAAAGAACTGGGCGGCGAACCTACCACCCAGAAAGAAGGC
AAGGTGGTTACCGGACAGGCTGTGCCCGTTATCTACGAAAGCGATGCGGACCAGGAAGAC
GCCACCATCGAGGCGTACAGTCAATTTCTCAAGGTCTGTAAGGAACAGGGCGATATCGTC
ACTGCCCGTCTTTTCGAGCGCATTATTGAAGAAGAACAGGCCCATCTGACATATTACGAA
AATATCGGCAGCCATATCAAAAATCTGGGCGACACGTATCTGGCAAAGATTGCCGGTACG
CCATCGTCCACAGGAACTGCCAGCAAGGGCTTTGTTACCGCTACTCCGGCTGCTGAATAG
GenBank Gene IDAF321851
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. da Costa PN, Romao CV, LeGall J, Xavier AV, Melo E, Teixeira M, Saraiva LM: The genetic organization of Desulfovibrio desulphuricans ATCC 27774 bacterioferritin and rubredoxin-2 genes: involvement of rubredoxin in iron metabolism. Mol Microbiol. 2001 Jul;41(1):217-27. 11454214
  2. Romao CV, Regalla M, Xavier AV, Teixeira M, Liu MY, Le Gall J: A bacterioferritin from the strict anaerobe Desulfovibrio desulfuricans ATCC 27774. Biochemistry. 2000 Jun 13;39(23):6841-9. 10841764
  3. Romao CV, Louro R, Timkovich R, Lubben M, Liu MY, LeGall J, Xavier AV, Teixeira M: Iron-coproporphyrin III is a natural cofactor in bacterioferritin from the anaerobic bacterium Desulfovibrio desulfuricans. FEBS Lett. 2000 Sep 1;480(2-3):213-6. 11034331
  4. Coelho AV, Macedo S, Matias PM, Thompson AW, LeGall J, Carrondo MA: Structure determination of bacterioferritin from Desulfovibrio desulfuricans by the MAD method at the Fe K-edge. Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):326-9. 11173495
  5. Macedo S, Romao CV, Mitchell E, Matias PM, Liu MY, Xavier AV, LeGall J, Teixeira M, Lindley P, Carrondo MA: The nature of the di-iron site in the bacterioferritin from Desulfovibrio desulfuricans. Nat Struct Biol. 2003 Apr;10(4):285-90. 12627224