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NameProbable asparagine--tRNA ligase, mitochondrial
Synonyms
  • 6.1.1.22
  • AsnRS
  • Asparaginyl-tRNA synthetase
Gene NameNARS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037194|Probable asparagine--tRNA ligase, mitochondrial
MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVL
FLHVNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGN
CDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHT
PIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGAFTQVFTFGP
TFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHK
FIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCG
NIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLA
RSGLTEVYQWYLDLRRFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPRFPHSCLL
Number of residues477
Molecular Weight54089.64
Theoretical pI7.26
GO Classification
Functions
  • ATP binding
  • nucleic acid binding
  • asparagine-tRNA ligase activity
Processes
  • gene expression
  • tRNA aminoacylation for protein translation
  • asparaginyl-tRNA aminoacylation
Components
  • mitochondrion
  • mitochondrial matrix
General FunctionNucleic acid binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID39644781
UniProtKB IDQ96I59
UniProtKB Entry NameSYNM_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0011681|Probable asparagine--tRNA ligase, mitochondrial (NARS2)
ATGTCAGGAGCTTTTACTCAAGTGTTTACCTTTGGTCCGACCTTCCGAGCTGAAAATTCT
CAGAGCCGGAGGCACCTGGCAGAGTTTTATATGATAGAAGCAGAGATTTCTTTTGTTGAC
AGCCTTCAAGATCTTATGCAGGTTATAGAGGAACTGTTCAAGGCTACAACAATGATGGTT
CTCTCAAAATGTCCTGAAGATGTTGAACTCTGTCACAAATTCATAGCACCTGGCCAAAAG
GACAGATTAGAACATATGCTAAAAAACAACTTTTTAATCATTTCTTATACTGAAGCAGTG
GAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTA
CGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATT
AATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCAC
ACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTC
AGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTC
TACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATG
GGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCT
TTCCCAAGGTTTCCTCATTCATGCCTTTTATAG
GenBank Gene IDBC007800
GeneCard IDNot Available
GenAtlas IDNARS2
HGNC IDHGNC:26274
Chromosome Location11
Locus11q14.1
References
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  6. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569
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  8. Sofou K, Kollberg G, Holmstrom M, Davila M, Darin N, Gustafsson CM, Holme E, Oldfors A, Tulinius M, Asin-Cayuela J: Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome. Mol Genet Genomic Med. 2015 Jan;3(1):59-68. doi: 10.1002/mgg3.115. Epub 2014 Oct 23. 25629079
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