T3DB: Kinesin-like protein KIF16B

Name	Kinesin-like protein KIF16B
Synonyms	C20orf23 KIAA1590 SNX23 Sorting nexin-23
Gene Name	KIF16B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009137\|Kinesin-like protein KIF16B MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDF SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSG LIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKE GPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEM PCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTL AKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIIN KPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEARVQELTK EWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYV GRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAV ILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFER QQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKR RSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEK AEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLR RGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLE KDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEY RLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQ ANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQ RHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYE VDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEG CSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDA HFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAER RSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG
Number of residues	1317
Molecular Weight	152010.17
Theoretical pI	Not Available
GO Classification	Functions phosphatidylinositol-3,4,5-trisphosphate binding ATP-dependent microtubule motor activity, plus-end-directed phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3-phosphate binding ATP binding phosphatidylinositol-3,4-bisphosphate binding Processes early endosome to late endosome transport endoderm development formation of primary germ layer microtubule-based movement Golgi to endosome transport receptor catabolic process epidermal growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway regulation of receptor recycling Components kinesin complex microtubule endosome early endosome early endosome membrane
General Function	Phosphatidylinositol-3-phosphate binding
Specific Function	Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
Pfam Domain Function	Kinesin (PF00225 ) PX (PF00787 ) FHA (PF00498 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q96L93
UniProtKB Entry Name	KI16B_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013635\|Kinesin-like protein KIF16B (KIF16B) ATGGCATCGGTCAAGGTGGCCGTGAGGGTCCGGCCCATGAATCGCAGGGAAAAGGACTTG GAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATA CCAGAAGGAGGCACTGGGGACTCAGGAAGAGAACGGACCAAGACCTTCACCTATGACTTT TCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAATGGTTTTCAAA ACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCA TATGGGCAAACTGGATCTGGAAAGTCATACACTATGATGGGAAATTCTGGAGATTCTGGC TTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCACCAGATGGGAT GAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGAT CTACTTCGGCGGAAGTCATCTAAAACCTTCAATTTGAGAGTCCGTGAGCATCCCAAAGAA GGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGACGTAGAAGAA CTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGT AGCAGGTCTCATGCCATCTTCACCATCAAGTTCACTCAGGCTAAATTTGATTCTGAAATG CCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGAGCGTGCAGAT GCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTG ACTCTGGGGAACGTCATTTCTGCCTTAGCTGATTTATCTCAGGATGCTGCAAATACTCTT GCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTGGTTGTTAAAA GATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTC AATTATGGAGAAACCCTAAGTACTCTTCGCTATGCAAATAGAGCCAAAAACATCATCAAC AAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCGAGCTGAAATA GCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACA GCTTTAAGTATGGAGGAAAAACTTCAGCAGAATGAAGCAAGAGTTCAAGAATTGACCAAG GAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAACTCTAGCCCTC AGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGAT GATGACCTTTTGAGTACTGGAATCATCTTATATCATTTAAAGGAAGGTCAGACATACGTT GGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGACTTGGAGAGT GAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCC CAGTGCTCTGTGAATGGTGTTCAGATCGTGGAGGCCACACATCTAAATCAAGGTGCTGTG ATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGCCGCCAAGCTC AGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCG AAGTCCCGTGAGAACCTGTCTGCAGTCATGTTGTATAACCCCGGACTTGAATTTGAGAGG CAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGAAGAAATGGAG GAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAG CGCAAGGAGACAGAAATCGTGCAGCTCCAGATTCGCAAGCAGGAGGAGAGCCTCAAACGC CGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGAAAAATTTGAA GAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAG ACCTTTCTCCGCGTCCAAGAAGAACTCCAACGACTCAAAGAACTCAACAACAACGAGAAG GCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAAAGATGAACAG TATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATG CTCGTGGCCCATCTGGAAGAGCAGCTCCGAGAGAAGCAGGAGATGATCCAGCTCCTGCGG CGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCATTCGGGAATCC CTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAG GCTCAACTGCGTTTCTTCGAATTCAAGAGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAG AAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGAACAGGAGATC CTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAG AGTGTCACAGATGTCACGGAAGTGCCTCAAGATTTCGAGAAAATAAAGCCAGTGGAGTAC AGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTTGCCAACTCTG TTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAAC ACTCTTTATCAAGTAGAAAAGGAAATGGAAGAAAAAGAAGAACAGCTTGCACAGTACCAG GCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGCCAACATTGCA CGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAG CAGAGAGAGGCGCTGGAGCGGGCCCTGGCCAGGCTGGAGAGGAGACATTCTGCGCTGCAG AGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGCCAGTCTGAAC AGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTG GAGAAGGACCAGGAGAGGATCAATGCTTACATTGAAGAAGAAGTCCAAAGACGCCTTCAG GATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAAT GAGAAACTTCACAATGGCACCATTCAACGTAAACTAAAATATGAGCGGATGGTTTCTCGC TCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAGTATCCCACGCTAC GTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTA GATGAGACATGGACTGTATTCAGGCGTTACAGTCGTTTTCGAGAAATGCATAAAACATTG AAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAAT AAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTT TTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACT CTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTAC AGCAGCCACGGGACGGGGTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:15869
Chromosome Location	20
Locus	Not Available
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Epub 2006 Sep 7. 16959974