NameChloride intracellular channel protein 6
Synonyms
  • CLIC1L
  • Parchorin
Gene NameCLIC6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009051|Chloride intracellular channel protein 6
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEA
GGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGE
PRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSV
EAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSV
DAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSG
DGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVG
DGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEE
GPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYD
GESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDV
NKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKAL
RKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDF
EFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
Number of residues704
Molecular Weight73010.875
Theoretical pINot Available
GO Classification
Functions
  • voltage-gated ion channel activity
  • chloride channel activity
Processes
  • chloride transmembrane transport
Components
  • cytoplasm
  • plasma membrane
  • extracellular exosome
  • chloride channel complex
General FunctionVoltage-gated ion channel activity
Specific FunctionMay insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
Pfam Domain Function
Transmembrane Regions489-509
GenBank Protein IDNot Available
UniProtKB IDQ96NY7
UniProtKB Entry NameCLIC6_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017675|Chloride intracellular channel protein 6 (CLIC6)
ATGGCCGAGGCCGCGGAGCCGGAGGGGGTTGCCCCGGGTCCCCAGGGGCCGCCGGAGGTC
CCCGCGCCTCTGGCTGAGAGACCCGGAGAGCCAGGAGCCGCGGGCGGGGAGGCAGAAGGG
CCGGAGGGGAGCGAGGGCGCAGAGGAGGCGCCGAGGGGCGCCGCCGCTGTGAAGGAGGCA
GGAGGCGGCGGGCCAGACAGGGGCCCGGAGGCCGAGGCGCGGGGCACGAGGGGGGCGCAC
GGCGAGACTGAGGCCGAGGAGGGAGCCCCGGAGGGTGCCGAGGTGCCCCAAGGAGGGGAG
GAGACAAGCGGCGCGCAGCAGGTGGAGGGGGCGAGCCCGGGACGCGGCGCGCAGGGCGAG
CCCCGCGGGGAGGCTCAGAGGGAGCCCGAGGACTCTGCGGCCCCCGAGAGGCAGGAGGAG
GCGGAGCAGAGGCCTGAGGTCCCGGAAGGTAGCGCGTCCGGGGAGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATAGAAGCGGAGGGCCCGGCGGGCGACAGCGTA
GAGGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATACAAGCCGAGGGCCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGAGGCGGGGGACCCGGCGGGGGACGGCGTA
GAAGCGGGGGTCCCGGCGGGGGACAGCGTAGAAGCCGAAGGCCCGGCGGGGGACAGCATG
GACGCCGAGGGTCCGGCAGGAAGGGCGCGCCGGGTCTCGGGTGAGCCGCAGCAATCGGGG
GACGGCAGCCTCTCGCCCCAGGCCGAGGCAATTGAGGTCGCAGCCGGGGAGAGTGCGGGG
CGCAGCCCCGGTGAGCTCGCCTGGGACGCAGCGGAGGAGGCGGAGGTCCCGGGGGTAAAG
GGGTCCGAAGAAGCGGCCCCCGGGGACGCAAGGGCAGACGCTGGCGAGGACAGGGTAGGG
GATGGGCCACAGCAGGAGCCGGGGGAGGACGAAGAGAGACGAGAGCGGAGCCCGGAGGGG
CCAAGGGAGGAGGAAGCAGCGGGGGGCGAAGAGGAATCCCCCGACAGCAGCCCACATGGG
GAGGCCTCCAGGGGCGCCGCGGAGCCTGAGGCCCAGCTCAGCAACCACCTGGCCGAGGAG
GGCCCCGCCGAGGGTAGCGGCGAGGCCGCGCGCGTGAACGGCCGCCGGGAGGACGGAGAG
GCGTCCGAGCCCCGGGCCCTGGGGCAGGAGCACGACATCACCCTCTTCGTCAAGGCTGGT
TATGATGGTGAGAGTATCGGAAATTGCCCGTTTTCTCAGCGTCTCTTTATGATTCTCTGG
CTGAAAGGCGTTATATTTAATGTGACCACAGTGGACCTGAAAAGGAAACCCGCAGACCTG
CAGAACCTGGCTCCCGGAACAAACCCTCCTTTCATGACTTTTGATGGTGAAGTCAAGACG
GATGTGAATAAGATCGAGGAGTTCTTAGAGGAGAAATTAGCTCCCCCGAGGTATCCCAAG
CTGGGGACCCAACATCCCGAATCTAATTCCGCAGGAAATGACGTGTTTGCCAAATTCTCA
GCGTTTATAAAAAACACGAAGAAGGATGCAAATGAGATTCATGAAAAGAACCTGCTGAAG
GCCCTGAGGAAGCTGGATAATTACTTAAATAGCCCTCTGCCTGATGAAATAGATGCCTAC
AGCACCGAGGATGTCACTGTTTCTGGAAGGAAGTTTCTGGATGGGGACGAGCTGACGCTG
GCTGACTGCAACCTCTTACCCAAGCTCCATATTATTAAGATTGTGGCCAAGAAGTACAGA
GATTTTGAATTTCCTTCTGAAATGACTGGCATCTGGAGATACTTGAATAATGCTTATGCT
AGAGATGAGTTCACAAATACGTGTCCAGCTGATCAAGAGATTGAACACGCATATTCAGAT
GTTGCAAAAAGAATGAAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2065
Chromosome Location21
LocusNot Available
References
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  2. Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, Vitale L, Carinci P, Zannotti M: Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. Mamm Genome. 2002 Aug;13(8):456-62. 12226712
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