NameSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial
Synonyms
  • CYB560
  • CYBL
  • Integral membrane protein CII-3
  • QPs-1
  • QPs1
  • SDH3
  • Succinate dehydrogenase complex subunit C
  • Succinate-ubiquinone oxidoreductase cytochrome B large subunit
Gene NameSDHC
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004430|Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM
Number of residues169
Molecular Weight18610.03
Theoretical pI10.12
GO Classification
Functions
  • heme binding
  • metal ion binding
  • succinate dehydrogenase activity
  • electron carrier activity
Processes
  • cellular metabolic process
  • oxidation-reduction process
  • respiratory electron transport chain
  • mitochondrial electron transport, succinate to ubiquinone
  • tricarboxylic acid cycle
  • aerobic respiration
  • small molecule metabolic process
Components
  • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
  • respiratory chain complex II
  • mitochondrion
  • mitochondrial inner membrane
  • integral component of membrane
General FunctionSuccinate dehydrogenase activity
Specific FunctionMembrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Pfam Domain Function
Transmembrane Regions63-92 113-137 145-166
GenBank Protein ID1814226
UniProtKB IDQ99643
UniProtKB Entry NameC560_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0011627|Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC)
ATGGCTGCGCTGTTGCTGAGACACGTTGGTCGTCATTGCCTCCGAGCCCACTTTAGCCCT
CAGCTCTGTATCAGAAATGCTGTTCCTTTGGGAACCACGGCCAAAGAAGAGATGGAGCGG
TTCTGGAATAAGAATATAGGTTCAAACCGTCCTCTGTCTCCCCACATTACTATCTACAGT
TGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCA
GATGTGGGACCTAGGAAAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGT
CCTGGTTCTTACTGTGTTGTCCTCTATGGGGCTGGCAGCCATGTGAAGAAAGGAGGCTCC
CAGCATCATCTTCCTACACATTATTACATTCACCCATCTTTCTGTTTGTCATTCTTATCT
CCAGCCTGGGAAAAGTTCTCCTTATTTGTTTAG
GenBank Gene IDU57877
GeneCard IDNot Available
GenAtlas IDSDHC
HGNC IDHGNC:10682
Chromosome Location1
Locus1q23.3
References
  1. Hirawake H, Taniwaki M, Tamura A, Kojima S, Kita K: Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. Cytogenet Cell Genet. 1997;79(1-2):132-8. 9533030
  2. Elbehti-Green A, Au HC, Mascarello JT, Ream-Robinson D, Scheffler IE: Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Gene. 1998 Jun 15;213(1-2):133-40. 9714607
  3. Wohllk N, Thomas PM, Huang E, Cote GJ: A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene. Mol Genet Metab. 1998 Nov;65(3):187-90. 9851882
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