NameThioredoxin, mitochondrial
Synonyms
  • MTRX
  • Thioredoxin-2
  • TRX2
Gene NameTXN2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017607|Thioredoxin, mitochondrial
MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
Number of residues166
Molecular Weight18383.165
Theoretical pINot Available
GO Classification
Functions
  • peptide-methionine (R)-S-oxide reductase activity
  • protein disulfide oxidoreductase activity
  • peptide-methionine (S)-S-oxide reductase activity
  • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Processes
  • response to hypoxia
  • response to axon injury
  • response to nutrient
  • response to hormone
  • response to glucose
  • response to drug
  • response to organic cyclic compound
  • cellular response to nutrient levels
  • protein folding
  • response to reactive oxygen species
  • cell redox homeostasis
  • sulfate assimilation
  • glycerol ether metabolic process
  • cellular response to oxidative stress
  • oxidation-reduction process
Components
  • dendrite
  • neuronal cell body
  • mitochondrion
  • mitochondrial matrix
  • nucleolus
General FunctionProtein disulfide oxidoreductase activity
Specific FunctionHas an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99757
UniProtKB Entry NameTHIOM_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0017608|Thioredoxin, mitochondrial (TXN2)
ATGGCTCAGCGACTTCTTCTGAGGAGGTTCCTGGCCTCTGTCATCTCCAGGAAGCCCTCT
CAGGGTCAGTGGCCACCCCTCACTTCCAGAGCCCTGCAGACCCCACAATGCAGTCCTGGT
GGCCTGACTGTAACACCCAACCCAGCCCGGACAATATACACCACGAGGATCTCCTTGACA
ACCTTTAATATCCAGGATGGACCTGACTTTCAAGACCGAGTGGTCAACAGTGAGACACCA
GTGGTTGTGGATTTCCACGCACAGTGGTGTGGACCCTGCAAGATCCTGGGGCCGAGGTTA
GAGAAGATGGTGGCCAAGCAGCACGGGAAGGTGGTGATGGCCAAGGTGGATATTGATGAC
CACACAGACCTCGCCATTGAGTATGAGGTGTCAGCGGTGCCCACTGTGCTGGCCATGAAG
AATGGGGACGTGGTGGACAAGTTTGTGGGCATCAAGGATGAGGATCAGTTGGAGGCCTTC
CTGAAGAAGCTGATTGGCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17772
Chromosome Location22
LocusNot Available
References
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  2. Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, Gustafsson JA, Spyrou G: Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem. 2002 Sep 6;277(36):33249-57. Epub 2002 Jun 21. 12080052
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  7. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. 19608861
  8. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569
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