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NameThioredoxin, mitochondrial
Synonyms
  • MTRX
  • Thioredoxin-2
  • TRX2
Gene NameTXN2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017607|Thioredoxin, mitochondrial
MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
Number of residues166
Molecular Weight18383.165
Theoretical pINot Available
GO Classification
Functions
  • peptide-methionine (R)-S-oxide reductase activity
  • protein disulfide oxidoreductase activity
  • peptide-methionine (S)-S-oxide reductase activity
  • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Processes
  • response to hormone
  • response to glucose
  • response to drug
  • response to organic cyclic compound
  • protein folding
  • cellular response to nutrient levels
  • response to reactive oxygen species
  • cell redox homeostasis
  • sulfate assimilation
  • glycerol ether metabolic process
  • cellular response to oxidative stress
  • oxidation-reduction process
  • response to hypoxia
  • response to axon injury
  • response to nutrient
Components
  • mitochondrion
  • mitochondrial matrix
  • nucleolus
  • dendrite
  • neuronal cell body
General FunctionProtein disulfide oxidoreductase activity
Specific FunctionHas an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99757
UniProtKB Entry NameTHIOM_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0017608|Thioredoxin, mitochondrial (TXN2)
ATGGCTCAGCGACTTCTTCTGAGGAGGTTCCTGGCCTCTGTCATCTCCAGGAAGCCCTCT
CAGGGTCAGTGGCCACCCCTCACTTCCAGAGCCCTGCAGACCCCACAATGCAGTCCTGGT
GGCCTGACTGTAACACCCAACCCAGCCCGGACAATATACACCACGAGGATCTCCTTGACA
ACCTTTAATATCCAGGATGGACCTGACTTTCAAGACCGAGTGGTCAACAGTGAGACACCA
GTGGTTGTGGATTTCCACGCACAGTGGTGTGGACCCTGCAAGATCCTGGGGCCGAGGTTA
GAGAAGATGGTGGCCAAGCAGCACGGGAAGGTGGTGATGGCCAAGGTGGATATTGATGAC
CACACAGACCTCGCCATTGAGTATGAGGTGTCAGCGGTGCCCACTGTGCTGGCCATGAAG
AATGGGGACGTGGTGGACAAGTTTGTGGGCATCAAGGATGAGGATCAGTTGGAGGCCTTC
CTGAAGAAGCTGATTGGCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17772
Chromosome Location22
LocusNot Available
References
  1. Chen Y, Cai J, Murphy TJ, Jones DP: Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. J Biol Chem. 2002 Sep 6;277(36):33242-8. Epub 2002 May 24. 12032145
  2. Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, Gustafsson JA, Spyrou G: Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem. 2002 Sep 6;277(36):33249-57. Epub 2002 Jun 21. 12080052
  3. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. 15461802
  4. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. 10591208
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  6. Xu G, Shin SB, Jaffrey SR: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19310-5. doi: 10.1073/pnas.0908958106. Epub 2009 Nov 5. 19892738
  7. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. 19608861
  8. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569
  9. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. 25944712
  10. Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP: Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2. Protein Sci. 2005 Oct;14(10):2610-21. 16195549