NameRibonucleoside-diphosphate reductase subunit beta
Synonyms
  • 1.17.4.1
  • Ribonucleotide reductase small subunit
Gene NamenrdF
OrganismMycobacterium leprae (strain TN)
Amino acid sequence
>lcl|BSEQ0012278|Ribonucleoside-diphosphate reductase subunit beta
MLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQ
LTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCS
TAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSS
RAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEV
EYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENH
DFFSGSGSSYVIGKAVVTEDEDWDF
Number of residues325
Molecular Weight37315.67
Theoretical pI4.43
GO Classification
Functions
  • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
  • metal ion binding
Processes
  • deoxyribonucleotide biosynthetic process
  • deoxyribonucleoside diphosphate metabolic process
  • DNA replication
Components
  • ribonucleoside-diphosphate reductase complex
General FunctionRibonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Specific FunctionProvides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9CBQ2
UniProtKB Entry NameRIR2_MYCLE
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0012279|Ribonucleoside-diphosphate reductase subunit beta (nrdF)
TTGTTGACTGGGAAGATGAAGCTAATTGACCGCGTTTCGGCGATTAATTGGAACTGGCTG
CAAGACGACAAGGACGCCGAGGTCTGGGACCGGCTGACTGGAAACTTCTGGCTGCCCGAG
AAGGTGCCGGTGTCCAACGATCTCCCGTCGTGGGGCACGCTGACTGCTAGTGAAAAGCAG
CTGACAATGCGGGTGTTCACCGGTTTGACGCTGCTCGACACGATCCAAGGCACGGTCGGA
GCGGTCAGCCTTATTCCTGATGCGCTAACGCCGCATGAGGAAGCCGTCTACACCAACATT
GCATTCATGGAGTCGGTGCACGCCAAGAGCTACAGTTCGATCTTTTCCACGCTGTGCTCG
ACAGCGGAGATCGACGAAGCGTTTCGCTGGTCGGAGGAGAACAACAACCTGCAGCGCAAA
GCTAAGATTGTGATGGAGTACTATCGAGGCGACGAACCGCTCAAGCGCAAGGTGGCCTCC
ACCTTGCTCGAAAGCTTCCTGTTTTACTCTGGGTTCTACCTGCCGATGTACTGGTCAAGT
CGGGCCAAGCTGACCAACACCGCTGATATGATTCGGCTGATCATCCGCGACGAAGCAGTC
CACGGTTACTATATCGGCTACAAATTTCAGCGTGGCTTGGTGTTGGTCGACGACGCCAGG
CGGGCAGAACTCAAGGAATACACCTACGAATTGCTCTTTGAGCTCTACGACAACGAGGTG
GAATACACCCAAGATCTCTACGACAGAGTCGGGTTGACCGAAGACGTCAAGAAGTTCTTG
CGCTACAACGCAAATAAGGCGTTGATGAACCTTGGCTACGAGGCGCTGTTCCCGCGGGAC
GAGACCGACGTGAACCCGGCGATCCTGTCGGCCTTGTCTCCCAACGCCGATGAGAATCAT
GACTTTTTCTCCGGCTCGGGGTCGTCGTATGTGATCGGGAAAGCCGTCGTCACTGAGGAC
GAGGACTGGGACTTCTAA
GenBank Gene IDAL583923
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C, Harris D, Mungall K, Basham D, Brown D, Chillingworth T, Connor R, Davies RM, Devlin K, Duthoy S, Feltwell T, Fraser A, Hamlin N, Holroyd S, Hornsby T, Jagels K, Lacroix C, Maclean J, Moule S, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutherford KM, Rutter S, Seeger K, Simon S, Simmonds M, Skelton J, Squares R, Squares S, Stevens K, Taylor K, Whitehead S, Woodward JR, Barrell BG: Massive gene decay in the leprosy bacillus. Nature. 2001 Feb 22;409(6823):1007-11. 11234002