NameProstaglandin F synthase
Synonyms
  • 1.1.1.188
  • Prostaglandin F2-alpha synthase
Gene NameNot Available
OrganismTrypanosoma brucei brucei
Amino acid sequence
>lcl|BSEQ0012186|Prostaglandin F synthase
MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGR
AIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDKFIDT
WKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCKSK
NIAVTAWSPLGQGHLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKEN
GNIFDFELTAEDIQVIDGMNAGHRYGPDPEVFMNDF
Number of residues276
Molecular Weight30992.385
Theoretical pI6.79
GO Classification
Functions
  • nucleotide binding
  • prostaglandin D2 11-ketoreductase activity
  • prostaglandin-F synthase activity
Processes
  • prostaglandin biosynthetic process
Components
  • cytoplasm
General FunctionProstaglandin-f synthase activity
Specific FunctionCatalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9GV41
UniProtKB Entry NamePGFS_TRYBB
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0006091|831 bp
ATGGCTCTCACTCAATCCCTAAAACTCTCGAATGGAGTGATGATGCCAGTTCTTGGTTTC
GGTATGTGGAAGTTACAGGATGGCAATGAAGCCGAGACGGCGACGATGTGGGCCATAAAA
AGCGGCTATCGTCACATCGATACTGCAGCCATCTATAAAAATGAAGAAAGCGCTGGCAGA
GCCATTGCCTCATGTGGTGTACCGCGGGAAGAGCTATTCGTCACGACGAAGCTTTGGAAC
TCCGACCAGGGATATGAGAGCACGCTGAGCGCATTTGAGAAGAGCATTAAGAAGCTCGGC
CTGGAATATGTTGACCTATACCTCATCCACTGGCCGGGGAAGGACAAGTTTATCGACACA
TGGAAGGCGTTTGAGAAACTGTACGCCGATAAGAAGGTGCGCGCCATTGGCGTTTCCAAC
TTTCACGAGCACCACATCGAGGAACTGCTAAAGCACTGTAAGGTTGCACCGATGGTTAAC
CAGATCGAGCTCCATCCGCTGCTCAATCAGAAGGCACTCTGCGAGTACTGCAAGTCGAAG
AACATCGCCGTCACTGCCTGGTCGCCGCTTGGTCAAGGACATCTCGTCGAAGACGCCCGT
CTGAAAGCTATCGGAGGAAAGTATGGTAAGACAGCTGCGCAGGTGATGCTCCGCTGGGAA
ATACAAGCAGGGGTCATCACGATTCCCAAATCGGGCAACGAGGCCCGCATCAAGGAAAAT
GGCAATATATTTGACTTCGAACTAACTGCGGAGGACATTCAAGTCATCGATGGTATGAAT
GCCGGCCACCGCTACGGCCCCGATCCGGAGGTCTTCATGAACGACTTTTGA
GenBank Gene IDAB034727
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O: Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med. 2000 Nov 6;192(9):1327-38. 11067881