NameSerine racemase
Synonyms
  • 5.1.1.18
  • D-serine ammonia-lyase
  • D-serine dehydratase
  • L-serine ammonia-lyase
  • L-serine dehydratase
Gene NameSRR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016075|Serine racemase
MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA
LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA
YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL
VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV
KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT
VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
Number of residues340
Molecular Weight36565.905
Theoretical pI6.51
GO Classification
Functions
  • PDZ domain binding
  • pyridoxal phosphate binding
  • glycine binding
  • ATP binding
  • calcium ion binding
  • L-serine ammonia-lyase activity
  • D-serine ammonia-lyase activity
  • serine racemase activity
  • magnesium ion binding
  • threonine racemase activity
  • protein homodimerization activity
Processes
  • brain development
  • aging
  • pyruvate biosynthetic process
  • L-serine metabolic process
  • response to morphine
  • D-serine metabolic process
  • response to drug
  • D-serine biosynthetic process
  • protein homotetramerization
  • serine family amino acid metabolic process
  • response to lipopolysaccharide
Components
  • neuronal cell body
  • apical part of cell
  • cytoplasm
  • plasma membrane
General FunctionThreonine racemase activity
Specific FunctionCatalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID11034785
UniProtKB IDQ9GZT4
UniProtKB Entry NameSRR_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0000772|1023 bp
ATGTGTGCTCAGTATTGCATCTCCTTTGCTGATGTTGAAAAAGCTCATATCAACATTCGA
GATTCTATCCACCTCACACCAGTGCTAACAAGCTCCATTTTGAATCAACTAACAGGGCGC
AATCTTTTCTTCAAATGTGAACTCTTCCAGAAAACAGGATCTTTTAAGATTCGTGGTGCT
CTCAATGCCGTCAGAAGCTTGGTTCCTGATGCTTTAGAAAGGAAGCCGAAAGCTGTTGTT
ACTCACAGCAGTGGAAACCATGGCCAGGCTCTCACCTATGCTGCCAAATTGGAAGGAATT
CCTGCTTATATTGTGGTGCCCCAGACAGCTCCAGACTGTAAAAAACTTGCAATACAAGCC
TACGGAGCGTCAATTGTATACTGTGAACCTAGTGATGAGTCCAGAGAAAATGTTGCAAAA
AGAGTTACAGAAGAAACAGAAGGCATCATGGTACATCCCAACCAGGAGCCTGCAGTGATA
GCTGGACAAGGGACAATTGCCCTGGAAGTGCTGAACCAGGTTCCTTTGGTGGATGCACTG
GTGGTACCTGTAGGTGGAGGAGGAATGCTTGCTGGAATAGCAATTACAGTTAAGGCTCTG
AAACCTAGTGTGAAGGTATATGCTGCTGAACCCTCAAATGCAGATGACTGCTACCAGTCC
AAGCTGAAGGGGAAACTGATGCCCAATCTTTATCCTCCAGAAACCATAGCAGATGGTGTC
AAATCCAGCATTGGCTTGAACACCTGGCCTATTATCAGGGACCTTGTGGATGATATCTTC
ACTGTCACAGAGGATGAAATTAAGTGTGCAACCCAGCTGGTGTGGGAGAGGATGAAACTA
CTCATTGAACCTACAGCTGGTGTTGGAGTGGCTGCTGTGCTGTCTCAACATTTTCAAACT
GTTTCCCCAGAAGTAAAGAACATTTGTATTGTGCTCAGTGGTGGAAATGTAGACTTAACC
TCCTCCATAACTTGGGTGAAGCAGGCTGAAAGGCCAGCTTCTTATCAGTCTGTTTCTGTT
TAA
GenBank Gene IDAF169974
GeneCard IDNot Available
GenAtlas IDSRR
HGNC IDHGNC:14398
Chromosome LocationNot Available
Locus17p13
References
  1. De Miranda J, Santoro A, Engelender S, Wolosker H: Human serine racemase: moleular cloning, genomic organization and functional analysis. Gene. 2000 Oct 3;256(1-2):183-8. 11054547
  2. Xia M, Liu Y, Figueroa DJ, Chiu CS, Wei N, Lawlor AM, Lu P, Sur C, Koblan KS, Connolly TM: Characterization and localization of a human serine racemase. Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):96-104. 15193426
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