NameMitochondrial folate transporter/carrier
Synonyms
  • MFT
  • MFTC
  • Solute carrier family 25 member 32
Gene NameSLC25A32
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010514|Mitochondrial folate transporter/carrier
MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP
KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA
TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR
GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA
ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY
ENVSHFLLDLREKRK
Number of residues315
Molecular Weight35406.83
Theoretical pI9.79
GO Classification
Functions
  • folic acid transporter activity
Processes
  • mitochondrial transport
  • small molecule metabolic process
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • glycine metabolic process
  • folic acid transport
  • folic acid metabolic process
Components
  • mitochondrial inner membrane
  • integral component of membrane
General FunctionFolic acid transporter activity
Specific FunctionTransports folate across the inner membranes of mitochondria.
Pfam Domain Function
Transmembrane Regions26-43 89-106 123-143 186-203 227-243 281-300
GenBank Protein ID11545417
UniProtKB IDQ9H2D1
UniProtKB Entry NameMFTC_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010515|Mitochondrial folate transporter/carrier (SLC25A32)
ATGACGGGCCAGGGCCAGTCGGCGTCCGGGTCGTCGGCGTGGAGCACGGTATTCCGCCAC
GTCCGGTATGAGAACCTGATAGCGGGCGTGAGCGGCGGCGTCTTATCCAACCTTGCGCTG
CATCCGCTCGACCTCGTGAAGATCCGCTTCGCCGTGAGTGATGGATTGGAACTGAGACCG
AAATATAATGGAATTTTACATTGCTTGACTACCATTTGGAAACTTGATGGACTACGGGGA
CTTTATCAAGGAGTAACCCCAAATATATGGGGTGCAGGTTTATCCTGGGGACTCTACTTT
TTCTTTTACAATGCCATCAAGTCATATAAAACAGAAGGAAGAGCTGAACGTTTAGAGGCA
ACAGAATACCTTGTCTCAGCTGCTGAAGCTGGAGCCATGACCCTCTGCATTACAAACCCA
TTATGGGTAACAAAAACTCGCCTTATGTTACAGTATGATGCTGTTGTTAACTCCCCACAC
CGACAATATAAAGGAATGTTTGATACACTTGTGAAAATATATAAGTATGAAGGTGTGCGT
GGATTATATAAGGGATTTGTTCCTGGGCTGTTTGGAACATCGCATGGTGCCCTTCAGTTT
ATGGCATATGAATTGCTGAAGTTGAAGTACAACCAGCATATCAATAGATTACCAGAAGCC
CAGTTGAGCACAGTAGAATATATATCTGTTGCAGCACTATCCAAAATATTTGCTGTCGCA
GCAACATACCCATATCAAGTCGTAAGAGCTCGTCTTCAGGATCAACACATGTTTTACAGT
GGTGTAATAGATGTAATCACAAAGACATGGAGGAAAGAAGGCGTCGGTGGATTTTACAAG
GGAATTGCTCCTAATTTGATTAGAGTGACTCCAGCCTGCTGTATTACCTTTGTGGTATAT
GAAAACGTCTCACATTTTTTACTTGACCTTAGAGAAAAGAGAAAGTAA
GenBank Gene IDAF283645
GeneCard IDNot Available
GenAtlas IDSLC25A32
HGNC IDHGNC:29683
Chromosome Location8
Locus8q22.3
References
  1. Titus SA, Moran RG: Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem. 2000 Nov 24;275(47):36811-7. 10978331
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