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Histone lysine demethylase PHF8

NameHistone lysine demethylase PHF8
Synonyms
  • 1.14.11.27
  • KIAA1111
  • PHD finger protein 8
  • ZNF422
Gene NamePHF8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037295|Histone lysine demethylase PHF8
MNRSRAIVQRGRVLPPPAPLDTTNLAGRRTLQGRAKMASVPVYCLCRLPYDVTRFMIECD
MCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGS
PTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTV
RDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLV
ETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEK
IFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTP
VDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLRE
NRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIF
QQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMSRLSLPSKNGSKKKGLKPKELFKKA
ERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDG
NESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDER
LGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEEDYTTDEDMVEGVEGKLGN
GSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQ
AWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDS
LGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGT
RVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAA
TPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRP
SVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL
Number of residues1060
Molecular Weight117862.955
Theoretical pINot Available
GO Classification
Functions
  • histone demethylase activity (H4-K20 specific)
  • iron ion binding
  • zinc ion binding
  • methylated histone binding
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
  • histone demethylase activity (H3-K9 specific)
  • histone demethylase activity (H3-K36 specific)
  • chromatin binding
  • histone demethylase activity
  • histone demethylase activity (H3-K27 specific)
Processes
  • brain development
  • transcription, DNA-templated
  • G1/S transition of mitotic cell cycle
  • positive regulation of transcription from RNA polymerase I promoter
  • chromatin organization
  • histone H4-K20 demethylation
  • histone H3-K9 demethylation
  • histone H3-K36 demethylation
  • negative regulation of chromatin silencing at rDNA
  • positive regulation of transcription, DNA-templated
  • histone H3-K27 demethylation
  • mitotic cell cycle
Components
  • nucleus
  • nuclear membrane
  • nucleolus
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionHistone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9UPP1
UniProtKB Entry NamePHF8_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021892|Histone lysine demethylase PHF8 (PHF8)
ATGAACAGGAGCCGCGCTATCGTCCAGAGAGGACGCGTGCTGCCGCCTCCCGCCCCTCTT
GACACGACGAACCTGGCCGGCCGCAGAACGCTCCAGGGCCGAGCGAAGATGGCCTCGGTG
CCGGTGTATTGCCTCTGCCGGCTGCCTTACGATGTGACCCGCTTCATGATCGAGTGTGAC
ATGTGCCAGGACTGGTTTCATGGCAGTTGTGTTGGTGTTGAAGAGGAGAAGGCTGCTGAC
ATTGACCTCTACCACTGCCCCAACTGTGAAGTCTTGCATGGGCCCTCCATTATGAAAAAA
CGCCGTGGATCTTCAAAGGGGCATGATACACACAAGGGGAAACCAGTGAAGACCGGGAGC
CCTACGTTCGTCAGAGAGCTCCGGAGTAGGACTTTTGACAGCTCAGATGAAGTGATTCTG
AAGCCCACTGGAAATCAACTGACCGTGGAATTCCTGGAAGAAAATAGCTTCAGTGTGCCC
ATCCTGGTCCTGAAGAAGGATGGGTTGGGCATGACGCTGCCCTCGCCATCATTCACTGTG
AGGGATGTTGAACACTATGTTGGTTCTGACAAAGAGATTGATGTGATTGATGTGACCCGC
CAGGCTGACTGCAAGATGAAGCTTGGTGATTTTGTGAAATACTATTACAGCGGGAAGAGG
GAGAAAGTCCTCAATGTCATTAGTTTGGAATTCTCTGATACCAGACTTTCTAACCTTGTG
GAGACACCGAAGATTGTTCGAAAGCTGTCATGGGTCGAAAACTTGTGGCCAGAGGAATGT
GTCTTTGAGAGACCCAATGTACAGAAGTACTGCCTCATGAGTGTGCGAGATAGCTATACA
GACTTTCACATTGACTTTGGTGGCACCTCTGTCTGGTACCATGTACTCAAGGGTGAAAAG
ATCTTCTACCTGATCCGCCCAACAAATGCCAATCTGACTCTCTTTGAGTGCTGGAGCAGT
TCCTCTAATCAGAATGAGATGTTCTTTGGGGACCAGGTGGACAAGTGCTACAAGTGTTCC
GTGAAGCAAGGACAGACACTTTTCATTCCCACAGGGTGGATCCATGCTGTGCTGACGCCT
GTGGACTGCCTTGCCTTTGGAGGGAACTTCTTACACAGCCTTAACATCGAGATGCAGCTC
AAAGCCTATGAGATTGAGAAGCGGCTGAGCACAGCAGACCTCTTCAGATTCCCCAACTTT
GAGACCATCTGTTGGTATGTGGGAAAGCACATCCTGGACATCTTTCGCGGTTTGCGAGAG
AACAGGAGACACCCTGCCTCCTACCTGGTCCATGGTGGCAAAGCCTTGAACTTGGCCTTT
AGAGCCTGGACAAGGAAAGAAGCTCTGCCAGACCATGAGGATGAGATCCCGGAGACAGTG
CGAACCGTACAGCTCATTAAAGATCTGGCCAGGGAGATCCGCCTGGTGGAAGACATCTTC
CAACAGAACGTTGGGAAGACGAGCAATATCTTTGGGCTGCAGAGGATCTTCCCAGCCGGC
TCCATTCCCCTAACCAGGCCAGCCCATTCCACTTCAGTGTCCATGTCCAGGCTGTCACTG
CCCTCCAAAAATGGTTCAAAGAAGAAAGGCCTGAAGCCCAAGGAACTCTTCAAGAAGGCA
GAGCGAAAGGGCAAGGAGAGTTCAGCCTTGGGGCCTGCTGGCCAGTTGAGCTATAATCTC
ATGGACACATACAGTCATCAGGCACTGAAGACAGGCTCTTTCCAGAAAGCAAAGTTCAAC
ATCACTGGTGCCTGCTTGAATGACTCAGATGACGACTCACCAGACTTGGACCTTGATGGA
AATGAGAGCCCATTGGCCCTATTGATGTCTAACGGCAGTACGAAAAGGGTGAAGAGTTTA
TCCAAATCTCGGCGAACCAAGATAGCAAAGAAGGTAGACAAGGCTAGGCTGATGGCAGAA
CAGGTGATGGAAGACGAATTTGACTTGGATTCAGATGATGAGCTGCAGATTGACGAGAGA
TTGGGAAAGGAGAAGGCGACCCTGATAATAAGACCAAAATTTCCCCGGAAATTGCCCCGT
GCGAAGCCTTGCTCTGACCCCAACCGAGTTCGTGAACCAGGAGAAGTTGAGTTTGACATT
GAGGAGGACTATACAACAGATGAGGACATGGTGGAAGGGGTTGAAGGCAAGCTTGGGAAT
GGTAGTGGCGCTGGTGGCATTCTTGATCTGCTCAAGGCCAGCAGGCAGGTGGGGGGACCT
GACTATGCTGCCCTCACCGAGGCCCCAGCTTCTCCCAGCACTCAGGAGGCCATCCAGGGC
ATGCTGTGCATGGCCAACCTGCAGTCCTCATCGTCCTCACCGGCTACCTCTAGCCTGCAG
GCCTGGTGGACTGGGGGACAGGATCGAAGCAGTGGGAGCTCCAGCAGTGGGCTGGGCACA
GTGTCTAACAGTCCTGCTTCCCAGCGCACCCCAGGGAAGCGGCCCATCAAGCGGCCAGCA
TACTGGAGAACCGAGAGCGAGGAGGAGGAGGAGAACGCCAGTCTGGATGAACAGGACAGC
TTGGGAGCGTGCTTCAAGGATGCAGAGTATATCTATCCTTCACTGGAGTCTGATGATGAT
GACCCTGCTTTGAAATCTCGACCCAAGAAAAAGAAGAATTCAGATGATGCTCCATGGAGT
CCTAAAGCCCGCGTGACCCCAACTCTGCCGAAGCAGGACCGTCCTGTGCGTGAGGGGACC
CGGGTAGCCTCTATTGAGACAGGTTTGGCTGCAGCAGCTGCAAAGCTGGCCCAGCAGGAG
CTACAGAAGGCCCAAAAGAAGAAATATATCAAGAAGAAGCCTTTGCTGAAGGAGGTAGAA
CAGCCTCGCCCTCAAGACTCCAATCTCAGTCTGACAGTACCAGCCCCCACTGTGGCTGCC
ACACCACAACTTGTCACCTCCTCCTCACCCCTGCCTCCTCCTGAGCCTAAACAAGAGGCC
CTGTCAGGAAGTCTCGCTGACCATGAGTACACCGCTCGTCCCAATGCCTTTGGCATGGCC
CAGGCAAACCGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCAGCGGCGCCCT
TCAGTTGGCTCCCAGAGCAATCAGGCAGGACAAGGAAAGCGTCCCAAAAAGGGCCTGGCC
ACAGCAAAGCAGAGACTCGGCCGTATCCTGAAAATCCACAGAAATGGCAAACTACTTCTG
TGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:20672
Chromosome LocationX
LocusNot Available
References
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