| Record Information |
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| Version | 2.0 |
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| Creation Date | 2009-06-22 16:08:31 UTC |
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| Update Date | 2014-12-24 20:24:33 UTC |
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| Accession Number | T3D1732 |
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| Identification |
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| Common Name | Hydrogen bromide |
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| Class | Small Molecule |
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| Description | Hydrogen bromide is a chemical compound of bromine. It forms hydrobromic acid, one of the strongest mineral acids known, when dissolved in water. Hydrogen bromide and its acid are mainly used for the production of inorganic bromides, especially the bromides of zinc, calcium, and sodium. They are also useful reagents for generating organobromine compounds. Bromine is a halogen element with the symbol Br and atomic number 35. Diatomic bromine does not occur naturally, but bromine salts can be found in crustal rock. Hydrogen bromide is an extremely irritating and corrosive gas. According to ILO [1971], however, bromine produces a more marked toxic action. AIHA [1958] reported that for humans, 40 to 60 ppm bromine is dangerous for short exposure [Henderson and Haggard 1943]. Because hydrogen bromide is considered less irritating than bromine, an IDLH of 50 ppm is chosen. |
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| Compound Type | - Bromide Compound
- Halogen
- Industrial/Workplace Toxin
- Inorganic Compound
- Non-Metal
- Synthetic Compound
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| Chemical Structure | |
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| Synonyms | | Synonym | | Acide bromhydrique | | Acido bromidrico | | Anhydrous hydrobromic acid | | Bromidohydrogen | | Bromowodor | | Bromure d'hydrogene | | Bromwasserstoff | | Broomwaterstof | | HBR | | Hydrobromic acid | | Hydrobromic acid solution | | Hydrogen bromide (HBr2) | | Hydrogen bromide in acetic acid | | Hydrogen bromide solution | | Hydrogen dibromide | | Hydrogenbromid | | [HBR] |
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| Chemical Formula | BrH |
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| Average Molecular Mass | 80.912 g/mol |
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| Monoisotopic Mass | 79.926 g/mol |
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| CAS Registry Number | 10035-10-6 |
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| IUPAC Name | hydrogen bromide |
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| Traditional Name | hydrogen bromide |
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| SMILES | Br |
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| InChI Identifier | InChI=1S/BrH/h1H |
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| InChI Key | InChIKey=CPELXLSAUQHCOX-UHFFFAOYSA-N |
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| Chemical Taxonomy |
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| Description | belongs to the class of inorganic compounds known as halogen hydrides. These are inorganic compounds in which the heaviest atom bonded to a hydrogen atom is a halogen. |
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| Kingdom | Inorganic compounds |
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| Super Class | Homogeneous non-metal compounds |
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| Class | Halogen organides |
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| Sub Class | Halogen hydrides |
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| Direct Parent | Halogen hydrides |
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| Alternative Parents | |
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| Substituents | - Halogen hydride
- Inorganic hydride
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| Molecular Framework | Not Available |
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| External Descriptors | |
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| Biological Properties |
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| Status | Detected and Not Quantified |
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| Origin | Exogenous |
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| Cellular Locations | |
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| Biofluid Locations | Not Available |
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| Tissue Locations | Not Available |
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| Pathways | Not Available |
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| Applications | Not Available |
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| Biological Roles | Not Available |
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| Chemical Roles | Not Available |
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| Physical Properties |
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| State | Gas |
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| Appearance | Colorless gas. |
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| Experimental Properties | | Property | Value |
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| Melting Point | -7.25°C | | Boiling Point | Not Available | | Solubility | Not Available | | LogP | Not Available |
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| Predicted Properties | |
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| Spectra |
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| Spectra | | Spectrum Type | Description | Splash Key | Deposition Date | View |
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| Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-0059-9000000000-ff07455e0ac66b1668c4 | 2017-09-20 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-001i-9000000000-d1e1c66f95d651afe765 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-001i-9000000000-d1e1c66f95d651afe765 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-001i-9000000000-d1e1c66f95d651afe765 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-9000000000-1412ecbe8b6cb8e29876 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-9000000000-1412ecbe8b6cb8e29876 | 2016-08-03 | View Spectrum | | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-9000000000-1412ecbe8b6cb8e29876 | 2016-08-03 | View Spectrum |
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| Toxicity Profile |
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| Route of Exposure | Oral (5) ; inhalation (5) ; dermal (5) |
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| Mechanism of Toxicity | Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (5, 6, 1) |
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| Metabolism | Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (5) |
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| Toxicity Values | LD50: 76 mg/kg (Intraperitoneal, Rat) (8)
LC50: 2858 ppm over 1 hour (Inhalation, Rat) (2) |
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| Lethal Dose | Not Available |
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| Carcinogenicity (IARC Classification) | No indication of carcinogenicity to humans (not listed by IARC). |
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| Uses/Sources | Hydrogen bromide and its acid are mainly used for the production of inorganic bromides, especially the bromides of zinc, calcium, and sodium. They are also useful reagents for generating organobromine compounds. (7) |
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| Minimum Risk Level | Not Available |
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| Health Effects | Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (4, 5, 6) |
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| Symptoms | Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (5, 6) |
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| Treatment | EYES: irrigate opened eyes for several minutes under running water.
INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice.
SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention.
INHALATION: supply fresh air. If required provide artificial respiration. |
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| Normal Concentrations |
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| Not Available |
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| Abnormal Concentrations |
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| Not Available |
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| External Links |
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| DrugBank ID | Not Available |
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| HMDB ID | Not Available |
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| PubChem Compound ID | 260 |
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| ChEMBL ID | 1231461 |
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| ChemSpider ID | 255 |
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| KEGG ID | C13645 |
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| UniProt ID | Not Available |
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| OMIM ID | |
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| ChEBI ID | 47266 |
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| BioCyc ID | BR- |
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| CTD ID | D018054 |
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| Stitch ID | Hydrogen bromide |
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| PDB ID | Not Available |
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| ACToR ID | 6178 |
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| Wikipedia Link | Hydrogen_bromide |
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| References |
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| Synthesis Reference | Not Available |
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| MSDS | T3D1732.pdf |
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| General References | - Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J: Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med. 2007 Jun;13(6):695-702. Epub 2007 May 27. [17529981 ]
- Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
- Golomb, BA (1999). A Review of the Scientific Literature As It Pertains to Gulf War Illnesses. Volume 2: Pyridostigmine Bromide. Washington, DC: RAND.
- Wikipedia. Bromine. Last Updated 9 June 2009. [Link]
- International Programme on Chemical Safety (IPCS) INCHEM (1992). Poison Information Monograph for Bromine. [Link]
- Wikipedia. Potassium bromide. Last Updated 9 June 2009. [Link]
- Wikipedia. Hydrobromic acid. Last Updated 14 May 2009. [Link]
- The Physical and Theoretical Chemistry Laboratory of Oxford University (2005). Material Safety Data Sheet (MSDS) for hydrogen bromide. [Link]
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| Gene Regulation |
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| Up-Regulated Genes | Not Available |
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| Down-Regulated Genes | Not Available |
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