Record Information
Version2.0
Creation Date2009-07-06 21:35:45 UTC
Update Date2014-12-24 20:25:47 UTC
Accession NumberT3D2638
Identification
Common NameNotexin
ClassProtein
DescriptionNotexin is a peptide toxin produced by the Common tiger snake (Notechis scutatus scutatus). It is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Snake Venom
Protein StructureT3d2638
Synonyms
Synonym
Basic phospholipase A2 notexin
Phosphatidylcholine 2-acylhydrolase
svPLA2
Chemical FormulaNot Available
Average Molecular Mass13593.310 g/mol
CAS Registry Number37233-96-4
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (4)
Mechanism of ToxicityNotexin is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (2)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesLD50: 0.214 mg/kg (Subcutaneous, Mouse) (5) LD50: 0.04 mg/kg (Intravenous, Mouse) (5)
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesNotexin is a peptide toxin produced by the Common tiger snake (Notechis scutatus scutatus). (2)
Minimum Risk LevelNot Available
Health EffectsNotexin is myotoxic. (2)
SymptomsBites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (1)
TreatmentAn antivenom exists for tiger snake venom. (3)
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP00608
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
PDB ID1AE7
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Dreisbach, RH (1983). Handbook of Poisoning. Los Altos, California: Lange Medical Publications.
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Antivenom. Last Updated 1 July 2009. [Link]
  4. Wikipedia. Snake venom. Last Updated 25 July 2009. [Link]
  5. Thomas S, Griessel E (1999). LD50 Scores for various snakes. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available