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Record Information
Creation Date2014-08-12 17:09:46 UTC
Update Date2014-12-24 20:26:34 UTC
Accession NumberT3D3945
Common Name2-Isopropylphenol
ClassSmall Molecule
Description2-Isopropylphenol is a flavouring ingredient 2-isopropylphenol belongs to the family of Cumenes. These are aromatic compounds containing a prop-2-ylbenzene moiety.
Compound Type
  • Flavouring Agent
  • Food Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Chemical Structure
2-(1-Methylethyl)phenol, 9CI
FEMA 3461
Isopropylphenol, ortho
Prodox 131
Chemical FormulaC9H12O
Average Molecular Mass136.191 g/mol
Monoisotopic Mass136.089 g/mol
CAS Registry Number88-69-7
IUPAC Name2-(propan-2-yl)phenol
Traditional Name2-isopropylphenol
InChI IdentifierInChI=1S/C9H12O/c1-7(2)8-5-3-4-6-9(8)10/h3-7,10H,1-2H3
Chemical Taxonomy
Description belongs to the class of organic compounds known as cumenes. These are aromatic compounds containing a prop-2-ylbenzene moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassCumenes
Direct ParentCumenes
Alternative Parents
  • Phenylpropane
  • Cumene
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
Cellular Locations
  • Membrane
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
AppearanceNot Available
Experimental Properties
Melting Point15 - 16°C
Boiling PointNot Available
Predicted Properties
Water Solubility3.09 g/LALOGPS
pKa (Strongest Acidic)10.5ChemAxon
pKa (Strongest Basic)-5.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity42.23 m³·mol⁻¹ChemAxon
Polarizability15.63 ųChemAxon
Number of Rings1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectrum TypeDescriptionSplash KeyView
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-00dr-9700000000-0a3ec6f0b6db49b1bb8cJSpectraViewer | MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-00dr-9700000000-0a3ec6f0b6db49b1bb8cJSpectraViewer | MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-00dr-6900000000-65b25162f6cb1b887f17JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-006x-8900000000-6f77c31ece141c6bd323JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0900000000-f27e4c86fd02f3a4d9f5JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-7900000000-b30b63f3decaee02aa55JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0uxu-9400000000-6296af1e3299f7217b19JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-0900000000-69d37dcc656ad26252a0JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-0900000000-36ddf0e1e27114cf431aJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00ku-7900000000-512c84878dbff828e6bfJSpectraViewer
MSMass Spectrum (Electron Ionization)splash10-00di-4900000000-0ab562a07073aa1cb86aJSpectraViewer | MoNA
1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
1D NMR13C NMR SpectrumNot AvailableJSpectraViewer
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
PubChem Compound ID6943
ChemSpider ID6677
KEGG IDNot Available
UniProt IDNot Available
ChEBI ID38506
BioCyc IDNot Available
CTD IDNot Available
Stitch IDNot Available
ACToR IDNot Available
Wikipedia LinkNot Available
Synthesis ReferenceNot Available
General References
  1. Chiha M, Merouani S, Hamdaoui O, Baup S, Gondrexon N, Petrier C: Modeling of ultrasonic degradation of non-volatile organic compounds by Langmuir-type kinetics. Ultrason Sonochem. 2010 Jun;17(5):773-82. doi: 10.1016/j.ultsonch.2010.03.007. Epub 2010 Mar 27. [20388590 ]
  2. Toyama T, Momotani N, Ogata Y, Miyamori Y, Inoue D, Sei K, Mori K, Kikuchi S, Ike M: Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment. Appl Environ Microbiol. 2010 Oct;76(20):6733-40. doi: 10.1128/AEM.00258-10. Epub 2010 Aug 27. [20802076 ]
  3. Li J, Ma M, Wang Z: In vitro profiling of endocrine disrupting effects of phenols. Toxicol In Vitro. 2010 Feb;24(1):201-7. doi: 10.1016/j.tiv.2009.09.008. Epub 2009 Sep 16. [19765641 ]
  4. Toyama T, Maeda N, Murashita M, Chang YC, Kikuchi S: Isolation and characterization of a novel 2-sec-butylphenol-degrading bacterium Pseudomonas sp. strain MS-1. Biodegradation. 2010 Apr;21(2):157-65. doi: 10.1007/s10532-009-9290-y. Epub 2009 Aug 25. [19705287 ]
  5. Cho S, Choi Y, Park S, Park T: Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet. J Nutr Biochem. 2012 Feb;23(2):192-201. doi: 10.1016/j.jnutbio.2010.11.016. Epub 2011 Mar 29. [21447440 ]
  6. Glenn GM, Klamczynski AP, Woods DF, Chiou B, Orts WJ, Imam SH: Encapsulation of plant oils in porous starch microspheres. J Agric Food Chem. 2010 Apr 14;58(7):4180-4. doi: 10.1021/jf9037826. [20196603 ]
  7. Shiizaki K, Asai S, Ebata S, Kawanishi M, Yagi T: Establishment of yeast reporter assay systems to detect ligands of thyroid hormone receptors alpha and beta. Toxicol In Vitro. 2010 Mar;24(2):638-44. doi: 10.1016/j.tiv.2009.10.001. Epub 2009 Oct 22. [19853653 ]
  8. Krcmar S: Responses of Tabanidae (Diptera) to canopy traps baited with 4-methylphenol, 3-isopropylphenol, and naphthalene. J Vector Ecol. 2007 Dec;32(2):188-92. [18260506 ]
  9. Harvey KA, Xu Z, Whitley P, Davisson VJ, Siddiqui RA: Characterization of anticancer properties of 2,6-diisopropylphenol-docosahexaenoate and analogues in breast cancer cells. Bioorg Med Chem. 2010 Mar 1;18(5):1866-74. doi: 10.1016/j.bmc.2010.01.045. Epub 2010 Jan 25. [20153203 ]
  10. Tsuchiya H, Ueno T, Tanaka T, Matsuura N, Mizogami M: Comparative study on determination of antioxidant and membrane activities of propofol and its related compounds. Eur J Pharm Sci. 2010 Jan 31;39(1-3):97-102. doi: 10.1016/j.ejps.2009.11.001. Epub 2009 Nov 6. [19897032 ]
  11. Leon I, Cocinero EJ, Millan J, Rijs AM, Usabiaga I, Lesarri A, Castano F, Fernandez JA: A combined spectroscopic and theoretical study of propofol.(H2O)3. J Chem Phys. 2012 Aug 21;137(7):074303. [22920116 ]
  12. Li J, Ma M, Wang Z: A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression. Toxicol Lett. 2008 Feb 15;176(3):198-206. doi: 10.1016/j.toxlet.2007.11.006. Epub 2007 Dec 3. [18207673 ]
  13. Feng Y, Colosi LM, Gao S, Huang Q, Mao L: Transformation and removal of tetrabromobisphenol A from water in the presence of natural organic matter via laccase-catalyzed reactions: reaction rates, products, and pathways. Environ Sci Technol. 2013 Jan 15;47(2):1001-8. doi: 10.1021/es302680c. Epub 2013 Jan 7. [23256593 ]
  14. Li J, Ma M, Wang Z: A two-hybrid yeast assay to quantify the effects of xenobiotics on thyroid hormone-mediated gene expression. Environ Toxicol Chem. 2008 Jan;27(1):159-67. [18092857 ]
  15. Alessio RJ, Li X, Martin DF: Removal of BPA model compounds and related substances by means of column chromatography using Octolig(R). J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(14):2198-204. doi: 10.1080/10934529.2012.707535. [22934990 ]
  16. Novak M, Brinster AM, Dickhoff JN, Erb JM, Jones MP, Leopold SH, Vollman AT, Wang YT, Glover SA: Chemistry of 4-alkylaryloxenium ion "precursors": sound and fury signifying something? J Org Chem. 2007 Dec 21;72(26):9954-62. Epub 2007 Nov 21. [18027966 ]
  17. Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available


General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
Uniprot ID:
Molecular Weight:
98987.9 Da
General Function:
Zinc ion binding
Specific Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Gene Name:
Uniprot ID:
Molecular Weight:
98979.96 Da