Browsing Toxins
Displaying toxin 3051 - 3075 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1772 | 2-Bromobutane 78-76-2 | C4H9Br 137.018 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 0 |
| T3D3981 | 2-Biphenylol 90-43-7 | C12H10O 170.207 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D3599 | 2-Aminophenol 95-55-6 | C6H7NO 109.126 g/mol |  |
| 2-Aminophenol interacts with both adult and fetal hemoglobin, forming methemoglobin. In comparison to its isomers, 3-aminophenol and 4-aminophenol, 2-aminophenol is th...more Number of Targets: 9 |
| T3D4213 | 2-Aminonaphthalene 91-59-8 | C10H9N 143.185 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D4165 | 2-Aminobenzoic acid 118-92-3 | C7H7NO2 137.136 g/mol |  |
| Uremic toxins such as anthranilic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can ...more Number of Targets: 6 |
| T3D1056 | 2-(Nitromethylidene)-1,3-thiazolidine 94662-60-9 | C4H6N2O2S 146.168 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D1046 | 2-(Nitromethylene)imidazolidine 13623-98-8 | C4H7N3O2 129.117 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D2225 | 2-(Chloroacetyl)dibenzofuran 13067-90-8 | C14H9ClO2 244.673 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2264 | 2,8-Dichlorodibenzofuran 5409-83-6 | C12H6Cl2O 237.081 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2052 | 2,8-Dichlorodibenzo-p-dioxin 38964-22-6 | C12H6Cl2O2 253.081 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah recepto...more Number of Targets: 4 |
| T3D2263 | 2,8-Dibromodibenzofuran 10016-52-1 | C12H6Br2O 325.983 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2421 | 2,7-Dichlorodibenzofuran 74992-98-6 | C12H6Cl2O 237.081 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2051 | 2,7-Dichlorodibenzo-p-dioxin 33857-26-0 | C12H6Cl2O2 253.081 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah recepto...more Number of Targets: 4 |
| T3D2258 | 2,7-Dibromodibenzofuran 65489-80-7 | C12H6Br2O 325.983 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D1668 | 2,6-Toluene diisocyanate 91-08-7 | C9H6N2O2 174.156 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 40 |
| T3D0261 | 2,6-Dinitrotoluene 606-20-2 | C7H6N2O4 182.134 g/mol |  |
| Dinitrotoluene may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are remov...more Number of Targets: 12 |
| T3D4867 | 2,6-Dimethylphenol 576-26-1 | C8H10O 122.164 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4218 | 2,6-Dimethylaniline 87-62-7 | C8H11N 121.180 g/mol |  |
| Treatment of AS52 cells with N-OH-2,6-dimethylaniline (2,6-DMA) and 2,6-DMAP led to intracellular production of reactive oxygen species (ROS). DNA strand breaks were o...more Number of Targets: 1 |
| T3D4884 | 2,6-Dimethyl-4-heptanone 108-83-8 | C9H18O 142.239 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4868 | 2,6-Diethylaniline 579-66-8 | C10H15N 149.233 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D2257 | 2,6-Dichlorodibenzofuran 60390-27-4 | C12H6Cl2O 237.081 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D0399 | 2,6-Dichlorobiphenyl 33146-45-1 | C12H8Cl2 223.098 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D1701 | 2,6-Dichlorobenzonitrile 1194-65-6 | C7H3Cl2N 172.011 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D1962 | 2,6-Dibromobiphenyl 59080-32-9 | C12H8Br2 312.000 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D4911 | 2,6-Di-tert-butyl-4-methylphenol 128-37-0 | C15H24O 220.351 g/mol |  |
| BHT is metabolized to quinone methides (QMs) which are responsible for promoting tumor formation in many animal models. One example of a QM is 2,6-di-tert-butyl-4-meth...more Number of Targets: 8 |