Browsing Toxins
Displaying toxin 401 - 425 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1542 | Tantalum(III) aluminide 12004-76-1 | AlTa 207.929 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D4714 | Tamoxifen 10540-29-1 | C26H29NO 371.515 g/mol |  |
| Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the ...more Number of Targets: 12 |
| T3D2525 | Tamapin 508220-81-3 | Not Available 3465.100 g/mol |  |
| Tamapin is a selective, potent, and reversible blocker of small conductance calcium-dependent potassium channels. It inhibits SK2 with the highest affinity, SK3 with a...more Number of Targets: 3 |
| T3D2585 | Taipoxin 52019-39-3 | Not Available 13828.660 g/mol |  |
| Taipoxin causes a gradual reduction to complete stop of evoked and spontaneous release of acetylcholine from motor nerve terminals. (L1106) Number of Targets: 0 |
| T3D2547 | Taicatoxin 112154-17-3 | Not Available 9711.255 g/mol |  |
| Taicatoxin blocks the voltage-dependent L-type calcium channels from the heart and on the small conductance calcium-activated potassium channels in the brain. (L1105) Number of Targets: 11 |
| T3D4732 | Tacrolimus 104987-11-3 | C44H69NO12 804.018 g/mol |  |
| The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in ato...more Number of Targets: 1 |
| T3D2772 | Tacrine 321-64-2 | C13H14N2 198.264 g/mol |  |
| Tacrine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 16 |
| T3D3664 | T2 Toxin 21259-20-1 | C24H34O9 466.521 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 6 |
| T3D4176 | Symmetric dimethylarginine 30344-00-4 | C8H18N4O2 202.254 g/mol |  |
| Uremic toxins such as symmetric dimethylarginine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic t...more Number of Targets: 3 |
| T3D1008 | Swep 1918-18-9 | C8H7Cl2NO2 220.053 g/mol |  |
| Swep is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of th...more Number of Targets: 2 |
| T3D3087 | Swainsonine 72741-87-8 | C8H15NO3 173.210 g/mol |  |
| Swainsonine inhibits the activity of glycoside hydrolases, especially N-linked glycosylation. Inhibition of Golgi mannosidase II and other alpha-mannosidases causes th...more Number of Targets: 10 |
| T3D2856 | Sumatriptan 103628-46-2 | C14H21N3O2S 295.400 g/mol |  |
| The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon...more Number of Targets: 14 |
| T3D5000 | Sulfuric acid 7664-93-9 | H2O4S 98.078 g/mol |  |
| Many strong acids cause tissue burns through the denaturation of proteins and partial hydrolysis of proteins. Most proteins denature at pH values of less than 3-4. T...more Number of Targets: 0 |
| T3D4998 | Sulfur-35 15117-53-0 | H2S 36.985 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1007 | Sulfocarbathione 114654-31-8 | C5H9NO2S3 211.325 g/mol |  |
| Sulfocarbathione is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active...more Number of Targets: 2 |
| T3D4466 | Sulfite 14265-45-3 | O3S 80.064 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D3924 | Sulfentrazone 122836-35-5 | C11H10Cl2F2N4O3S 387.190 g/mol |  |
| Not Available Number of Targets: 11 |
| T3D2892 | Sulfasalazine 599-79-1 | C18H14N4O5S 398.393 g/mol |  |
| The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the a...more Number of Targets: 18 |
| T3D1006 | Sulfallate 95-06-7 | C8H14ClNS2 223.786 g/mol |  |
| The metabolic products of triallate, diallate and sulfallate appear to be mutagenic or carcinogenic. In particular, the 2-chloro-allyl group is responsible for the mu...more Number of Targets: 3 |
| T3D2865 | Sufentanil 56030-54-7 | C22H30N2O2S 386.551 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 4 |
| T3D4471 | Succinylacetone 51568-18-4 | C7H10O4 158.152 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4999 | Succinyl acetoacetate 65115-74-4 | C8H10O6 202.161 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D1710 | Succinonitrile 110-61-2 | C4H4N2 80.088 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D5001 | Succinic acid semialdehyde 692-29-5 | C4H6O3 102.089 g/mol |  | Not Available | Not Available Number of Targets: 0 |
| T3D4453 | Succinic acid 110-15-6 | C4H6O4 118.088 g/mol |  |
| Succinate can inhibit the activities of α-KG–dependent oxygenases (KDMs) and the TET family of 5-methlycytosine (5mC) hydroxylases. Succinate also mediates allosteric ...more Number of Targets: 41 |