Eledoisin (Eledone cirrhosa) (T3D2549)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesGene RegulationTargets (3)XML
Targets (3)
Record Information
Version2.0
Creation Date2009-07-03 22:19:20 UTC
Update Date2014-12-24 20:25:41 UTC
Accession NumberT3D2549
Identification
Common NameEledoisin (Eledone cirrhosa)
ClassProtein
DescriptionEledoisin is a tachykinin peptide found in the Curled octopus (Eledone cirrhosa). (2)
Compound Type
  • Amide
  • Amine
  • Animal Toxin
  • Marine Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Protein StructureT3d2549
Synonyms
Synonym
Eledoisin
Eledosine
Chemical FormulaNot Available
Average Molecular Mass1206.410 g/mol
CAS Registry Number69-25-0
SequenceNot Available
Chemical Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateLiquid
AppearanceClear solution.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
Solubility>10 mg/mL
LogPNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Toxicity Profile
Route of ExposureInjection (sting/bite) (4)
Mechanism of ToxicityEledoisin is a tachykinin peptide. Tachykinins excite neurons, evoke behavioural responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. This is done by acting at the three tachykinin receptors. (1, 2, 3)
MetabolismFree toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesEledoisin is a tachykinin peptide found in the Curled octopus (Eledone cirrhosa). (2)
Minimum Risk LevelNot Available
Health EffectsEledoisin is a tachykinin peptide. Tachykinins excite neurons, evoke behavioral responses, are potent vasodilators and contract (directly or indirectly) many smooth muscles. (3)
SymptomsEledoisin is a tachykinin peptide. Tachykinins produce a variety of symptoms that include vasodilation, hypertension, and stimulation of extravascular smooth muscle. (2)
TreatmentNot Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
PubChem Compound IDNot Available
ChEMBL IDNot Available
ChemSpider IDNot Available
KEGG IDNot Available
UniProt IDP62933
OMIM ID
ChEBI IDNot Available
BioCyc IDNot Available
CTD IDNot Available
Stitch IDEledoisin
PDB ID1MXQ
ACToR IDNot Available
Wikipedia LinkNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  2. Wikipedia. Eledoisin. Last Updated 20 May 2009. [Link]
  3. Wikipedia. Tachykinin peptides. Last Updated 20 May 2009. [Link]
  4. Wikipedia. Mollusca. Last Updated 5 August 2009. [Link]
Gene Regulation
Up-Regulated GenesNot Available
Down-Regulated GenesNot Available

Targets

Target Details
1. Neuromedin-K receptor
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Gene Name:
TACR3
Uniprot ID:
P29371
Molecular Weight:
52201.35 Da
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Eledoisin. Last Updated 20 May 2009. [Link]
  4. Wikipedia. Tachykinin peptides. Last Updated 20 May 2009. [Link]
Target Details
2. Substance-K receptor
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Gene Name:
TACR2
Uniprot ID:
P21452
Molecular Weight:
44441.705 Da
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Eledoisin. Last Updated 20 May 2009. [Link]
  4. Wikipedia. Tachykinin peptides. Last Updated 20 May 2009. [Link]
Target Details
3. Substance-P receptor
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Gene Name:
TACR1
Uniprot ID:
P25103
Molecular Weight:
46250.5 Da
References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [15531486 ]
  2. The UniProt Consortium. The Universal Protein Resource (UniProt) Nucleic Acids Res. 2008;36:D190-D195.
  3. Wikipedia. Eledoisin. Last Updated 20 May 2009. [Link]
  4. Wikipedia. Tachykinin peptides. Last Updated 20 May 2009. [Link]