Browsing Toxins
Displaying toxin 2901 - 2925 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0392 | 4-Chlorobiphenyl 2051-62-9 | C12H9Cl 188.653 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 8 |
| T3D2036 | 4-Bromobiphenyl Ether 101-55-3 | C12H9BrO 249.103 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D2306 | 4-Bromo-2,3,7,8-tetrachlorodibenzofuran 115656-08-1 | C12H3BrCl4O 384.868 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2553 | 4-Aminopyridine 504-24-5 | C5H6N2 94.115 g/mol |  |
| 4-Aminopyridine blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals (A316). In MS, axons are progress...more Number of Targets: 17 |
| T3D3600 | 4-Aminophenol 123-30-8 | C6H7NO 109.126 g/mol |  |
| 4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio...more Number of Targets: 6 |
| T3D0232 | 4-Aminobiphenyl 92-67-1 | C12H11N 169.222 g/mol |  |
| 4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio...more Number of Targets: 2 |
| T3D0909 | 4-Amino-3,5-xylyl methylcarbamate 831-76-5 | C10H14N2O2 194.230 g/mol |  |
| 4-Amino-3,5-xylyl methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylat...more Number of Targets: 2 |
| T3D4895 | 4-Acetyl-6-tert-butyl-1,1-dimethylindane 13171-00-1 | C17H24O 244.372 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D0908 | 4-(Methylthio)-m-tolyl methylcarbamate 3566-00-5 | C10H13NO2S 211.281 g/mol |  |
| 4-(Methylthio)-m-tolyl methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbam...more Number of Targets: 2 |
| T3D3984 | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol 76014-81-8 | C10H15N3O2 209.245 g/mol |  |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a substrate of UDP-glucuronyl transferase, leading to the formation of [4-(methylnitrosamino)-1-(3-pyridyl)but-...more Number of Targets: 0 |
| T3D0907 | 4-(Methylamino)-3,5-xylyl methylcarbamate 10389-50-1 | C11H16N2O2 208.257 g/mol |  |
| 4-(Methylamino)-3,5-xylyl methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by car...more Number of Targets: 2 |
| T3D0805 | 4-(4-Chloro-2-methylphenoxy)butanoic acid 94-81-5 | C11H13ClO3 228.672 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D0102 | 4,6-Dinitro-o-cresol 534-52-1 | C7H6N2O5 198.133 g/mol |  |
| 4,6-Dinitro-o-cresol is an uncoupler of oxidative phosphorylation. It is believed to cause an acceleration of metabolic processes that are part of the tricarboxylic ac...more Number of Targets: 4 |
| T3D4907 | 4,5-Dichloro-3H-1,3-dithiol-2-one 1192-52-5 | C3Cl2OS2 187.068 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0312 | 4,4-Arsenobis(2-aminophenol) dihydrochloride 139-93-5 | C12H14As2Cl2N2O2 439.001 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4672 | 4,4'-Methylenedianiline 101-77-9 | C13H14N2 198.264 g/mol |  |
| After 4,4'-Methylenedianiline enters to our body, it is transported in the blood or stored in tissues. The N-N-acetylation of the compound leads to the formation of so...more Number of Targets: 3 |
| T3D0152 | 4,4'-Methylenebis(2-chloroaniline) 101-14-4 | C13H12Cl2N2 267.154 g/mol |  |
| MBOCA's carcinogenicity is thought to be a result of its ability to bind to DNA, hemoglobin, and serum albumin. One metabolite in particular, N-hydroxy-N,N’-diacetyl M...more Number of Targets: 49 |
| T3D0404 | 4,4'-Dichlorobiphenyl 2050-68-2 | C12H8Cl2 223.098 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D2037 | 4,4'-Dibromobiphenyl Ether 2050-47-7 | C12H8Br2O 327.999 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D2019 | 4,4'-Dibromobiphenyl 92-86-4 | C12H8Br2 312.000 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1067 | 3-[(2E)-2-(Nitromethylidene)hydrazinyl]benzoic acid 91978-88-0 | C8H7N3O4 209.159 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D0906 | 3-tert-Butylphenyl sec-butylcarbamate 97508-29-7 | C15H23NO2 249.349 g/mol |  |
| 3-tert-Butylphenyl sec-butylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamo...more Number of Targets: 2 |
| T3D0905 | 3-Oxo-carbofuran 16709-30-1 | C12H13NO4 235.236 g/mol |  |
| 3-Oxo-carbofuran is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active...more Number of Targets: 2 |
| T3D1944 | 3-Monobromobiphenyl 2113-57-7 | C12H9Br 233.104 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D2405 | 3-Methylpentane 96-14-0 | C6H14 86.175 g/mol |  |
| Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more Number of Targets: 4 |