Browsing Toxins
Displaying toxin 3076 - 3100 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0139 | Iodine-129 15046-84-1 | I 128.905 g/mol |  |
| Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy...more Number of Targets: 11 |
| T3D0868 | 4-Chlorophenol 106-48-9 | C6H5ClO 128.556 g/mol |  |
| 4-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph...more Number of Targets: 3 |
| T3D0245 | 2-Chlorophenol 95-57-8 | C6H5ClO 128.556 g/mol |  |
| 2-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph...more Number of Targets: 5 |
| T3D0380 | Cadmium oxide fume 1306-19-0 | CdO 128.410 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D4829 | 1-Octen-3-Ol 3391-86-4 | C8H16O 128.212 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0078 | Naphthalene 91-20-3 | C10H8 128.171 g/mol |  |
| PAH's such as naphthalene are transported throughout the body after binding blood proteins such as albumin. Binding to the aryl hydrocarbon receptor or glycine N-methy...more Number of Targets: 12 |
| T3D0635 | Azulene 275-51-4 | C10H8 128.171 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D4987 | Dihydro-5-propyl-2(3H)-furanone 57129-71-2 | C7H12O2 128.169 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D1707 | Phthalonitrile 91-15-6 | C8H4N2 128.131 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D4332 | Dihydrothymine 696-04-8 | C5H8N2O2 128.129 g/mol |  |
| Dihydropyrimidine dehydrogenase catalyzes the reduction of thymine to 5, 6-dihydrothymine then dihydropyrimidinase hydrolyzes 5, 6-dihydrothymine to N-carbamyl-b-alani...more Number of Targets: 0 |
| T3D1712 | Tetracyanoethylene 670-54-2 | C6N4 128.091 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D1302 | Arsole 287-77-4 | C4H5As 128.004 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4028 | (S)-2-Propylpiperidine 458-88-8 | C8H17N 127.227 g/mol |  |
| (S)-2-Propylpiperidine is a neurotoxin which disrupts the peripheral nervous system. It is toxic to humans and all classes of livestock; less than 0.2g is fatal to hum...more Number of Targets: 0 |
| T3D1050 | Nitro-methylene-cyclopentane 27861-40-1 | C6H9NO2 127.141 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D0639 | Beryllium acetate 543-81-7 | C4H6BeO4 127.100 g/mol |  |
| Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a m...more Number of Targets: 3 |
| T3D1827 | Selenium trioxide 13768-86-0 | O3Se 126.960 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1640 | Vanadium(V) oxytrifluoride 13709-31-4 | F3H3OV 126.960 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D1545 | Dichloroethylaluminum 563-43-9 | C2H5AlCl2 126.949 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1636 | Vanadium(IV) fluoride 10049-16-8 | F4V 126.935 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D4186 | 2-Octenal 2363-89-5 | C8H14O 126.196 g/mol |  |
| Uremic toxins such as 2-Octenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimula...more Number of Targets: 3 |
| T3D3520 | Melamine 108-78-1 | C3H6N6 126.120 g/mol |  |
| Melamine causes carcinomas of the urinary bladder at high doses (in male rats). Formation of bladder stones occurred and these calculi are necessary for the induction ...more Number of Targets: 1 |
| T3D4828 | Ethylphosphate 78-40-0 | C2H7O4P 126.048 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0282 | Arsenous acid 13464-58-9 | AsH3O3 125.944 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0725 | Zinc carbonate 3486-35-9 | CO3Zn 125.418 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D1702 | Ethyl cyanoacrylate 7085-85-0 | C6H7NO2 125.125 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |