Search Results for compounds

Matched description: … cellular sterol depletion (e.g. statin-treated cells) and rapidly degraded in sterol-loaded cells. In ... mammalian cells, this enhanced degradation is dependent on the presence of both a sterol and a non ... biosynthesis, induction of apoptosis, inhibition of cell cycle progression and actin cytoskeletal …

Matched symptoms: … Shellfish poisoning may cause numbness and tingling of the lips, tongue, face, and extremities ... , followed nausea and vomiting. Convulsions and progression to respiratory paraylsis may occur. (A594) …
Matched treatment: … bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered ... , atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the ... effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in …
Matched synonyms: … (2E)-2-[(E)-2-(acetyloxy)ethenyl]-4-(2,2-dimethyl-6-methylenecyclohexyl)-2-Butenal …

Matched symptoms: … inflammation of the intestinal tract, and loss of appetite. Some lesions may be found in the intestines and ... in the mouth and throat. Cutaneous anthrax infection in humans shows up as a boil-like skin lesion …
Matched treatment: … Treatment for anthrax infection includes large doses of intravenous and oral antibiotics, such as ... possible death. There is an anthrax vaccination licensed under the trade name BioThrax. (L1724) …
Matched description: … translocation of EF and LF into the cytosol. The anthrax toxins consist of three distinct proteins ... : the protective antigen (PA; 83 kDA), the edema factor (EF; 89 kDA) and the lethal factor (LF; 90 ... kDa). Individually, none of the three is toxic; PA combined with LF is the lethal toxin (LeTx) and PA combined with EF is the edema toxin (EdTx). (A338, A339) …

Matched symptoms: … Symptoms of overdose include respiratory failure and cardiac arrest leading to death. …
Matched treatment: … activated charcoal, osmotic diuresis, forced acid diuresis, and careful monitoring of CNS or …
Matched description: … Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for ... some years in the mid-1990s approved by the United States Food and Drug Administration for the …

Matched symptoms: … the mouth, digestive tract and vagina can also occur with antibiotics …
Matched treatment: … gastric lavage. The patient should be carefully observed (including ECG monitoring) and given symptomatic ... and supportive treatment. Adequate hydration should be maintained. (L1712) …
Matched description: … members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Bristol-Myers ... Squibb introduced Gatifloxacin in 1999 under the proprietary name Tequin™ for the treatment of ... tablets and in various aqueous solutions for intravenous therapy. [Wikipedia] …

Matched symptoms: … Causes severe eye and skin burns. Irritating to eyes, skin, and respiratory system. Acute exposure ... (ingestion or inhalation) can lead to coma, nausea, vomiting, and metabolic acidosis may occur. …
Matched treatment: … cold running water for at least 15 minutes, followed by thorough washing with soap and water. If ... necessary, the person should shower and change contaminated clothing and shoes, and then must seek …
Matched description: … a pleasant aromatic odour. o-Xylyl bromide is highly toxic, irritant and lachrymatory, and has been ... of Bolimów in January 1915. In the absence of clarification, the name "xylyl bromide" may refer to …

Matched description: … (sometimes called a triton) contains one proton and two neutrons, whereas the nucleus of protium (by ... far the most abundant hydrogen isotope) contains one proton and no neutrons. Naturally occurring ... with cosmic rays. The name of this isotope is formed from the Greek word "tritos" meaning "third". …

Matched symptoms: … Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness ... , giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L96, L97) …
Matched treatment: … Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the ... cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that …
Matched description: … Hydrogen cyanide (with the historical common name of Prussic acid) is a chemical compound with …

Matched treatment: … General supportive measures should be employed, along with intravenous fluids, and an adequate ... a general rule, medical observation and supportive care are the mainstay of treatment of …
Matched description: … Pinazepam (marketed under the brand name Domar and Duna) is a drug which is a benzodiazepine. It ... possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. …

Matched symptoms: … Manganese mainly affects the nervous system and may cause behavioral changes and other nervous ... system effects, which include movements that may become slow and clumsy. This combination of symptoms …
Matched description: … health foods, in ceramics as a glaze colorant and flux, and in concrete stains. Manganese is a ... naturally occurring metal with the symbol Mn and the atomic number 25. It does not occur naturally in ... , sulfur, or chlorine. Manganese occurs naturally in most foods and small amounts are needed to stay …
Matched synonyms: … Carbonic acid (acd/name 4.0) …

Matched symptoms: … arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but ... breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can ... cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808) …
Matched description: … is a metallic element with the chemical symbol Ag and atomic number 47. It occurs naturally in its ... pure, free form, as an alloy with gold and other metals, and in minerals such as argentite and chlorargyrite. (L808, L809, L815) …
Matched synonyms: … Carbonic acid (acd/name 4.0) …

Matched symptoms: … , headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal ... ulcers, runny nose, and breathing problems, such as asthma, cough, shortness of breath, or wheezing ... . Ingestion of hexavalent chromium causes irritation and ulcers in the stomach and small intestine, as …
Matched description: … Lead chromate is a chemical compound of lead and chromium commonly found in paints under the name ... solution. Lead is a heavy metal and stable element with the symbol Pb and the atomic number 82, existing in ... metallic, organic, and inorganic forms. It is mainly found in nature as the mineral galena (PbS …

Matched symptoms: … pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5) …
Matched treatment: … Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7) …
Matched description: … . Thiomersal was developed and registered under the trade name Merthiolate in 1928 by the ... Thiomersal is an organomercuric compound. It is used mainly as an antiseptic and antifungal agent ... pharmaceutical corporation Eli Lilly and Company and has been used as a preservative in vaccines, immunoglobulin …

Matched symptoms: … Acute exposure to PAHs causes irritation and inflammation of the skin and lung tissue. (A10) …
Matched description: … including Mentha species. Also present in cocoa, black tea and scotch whiskey. Quinoline is a flavouring ... ingredient Quinoline is a heterocyclic aromatic organic compound. It has the formula C9H7N and is a ... and later brown. Quinoline is only slightly soluble in cold water but dissolves readily in hot …

Matched symptoms: … Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity. …
Matched toxicity: … Oral, rat LD₅₀: 491 mg/kg for males and 279 mg/kg for females (A308). …
Matched treatment: … (such as with cyproheptadine and/or temperature control) may be considered. In case of acute overdose ... drug. An adequate airway, oxygenation, and ventilation should be assured, and cardiac rhythm and ... to decrease AUC and Cmax by an average of one-third, although some subjects had a limited effect of …
Matched description: … Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug ... related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It ... is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for …

Matched symptoms: … , high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting. …
Matched description: … , rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce ... numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by ... Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form. …

Matched symptoms: … inflammation of the intestinal tract, and loss of appetite. Some lesions may be found in the intestines and ... in the mouth and throat. Cutaneous anthrax infection in humans shows up as a boil-like skin lesion …
Matched treatment: … Treatment for anthrax infection includes large doses of intravenous and oral antibiotics, such as ... possible death. There is an anthrax vaccination licensed under the trade name BioThrax. (L1724) …
Matched description: … antigen (PA; 83 kDA), the edema factor (EF; 89 kDA) and the lethal factor (LF; 90 kDa). Individually ... , none of the three is toxic; PA combined with LF is the lethal toxin (LeTx) and PA combined with EF is the edema toxin (EdTx). (A338, A339) …

Matched treatment: … any antidepressant. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm ... and vital signs. General supportive and symptomatic measures are also recommended. Induction of emesis ... , forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. No specific antidotes for nefazodone are known. (L1712) …
Matched description: … Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers …

Matched symptoms: … MCADD presents in early childhood with hypoketotic hypoglycemia and liver dysfunction, often …
Matched treatment: … Management of acute MCADD includes rapid correction of hypoglycemia, rehydration and treatment of ... fasting and a high carbohydrate low-fat diet, but it does not fully prevent the crises and the neurological alterations. (A15457) …
Matched description: … systematic name octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid ... Caprylic acid is the common name for the eight-carbon straight chain fatty acid known by the ... commercially in the production of esters used in perfumery and also in the manufacture of dyes. …

Matched symptoms: … Avermectins cause irritation of skin and eyes, central nervous system depression (incoordination ... , tremors, lethargy, excitation, pupil dilation, coma), vomiting, convulsions and/or tremors, and …
Matched description: … medicine. It is sold under brand names Sklice and Stromectol in the United States, Ivomec in Europe ... by Merial Animal Health, Mectizan in Canada by Merck and Ivexterm in Mexico by Valeant ... . under the trade name Scabo 6. While in development, it was assigned the code MK-933 by Merck. It …

Matched symptoms: … contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090) …
Matched description: … The name vitamin B12 is used in two different ways. In a broad sense it refers to a group of cobalt ... use of cyanide in the purification procedures), hydroxocobalamin and the two coenzyme forms of B12 ... , methylcobalamin (MeB12) and 5-deoxyadenosylcobalamin (adenosylcobalamin - AdoB12). In a more specific …

Matched symptoms: … Causes severe eye and skin burns. Irritating to eyes, skin, and respiratory system. Acute exposure ... (ingestion or inhalation) can lead to coma, nausea, vomiting, and metabolic acidosis may occur. …
Matched treatment: … cold running water for at least 15 minutes, followed by thorough washing with soap and water. If ... necessary, the person should shower and change contaminated clothing and shoes, and then must seek …
Matched description: … a pleasant aromatic odour. p-Xylyl bromide is highly toxic, irritant and lachrymatory, and has been ... of Bolimów in January 1915. In the absence of clarification, the name "xylyl bromide" may refer to …

Matched symptoms: … , nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, and yellow eyes or skin. (L1536) …
Matched description: … conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and ... , inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis ... . Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone. …

Matched symptoms: … Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory ... depression. Levels greater than 40 µg/mL have caused toxicity and coma has been seen at levels of 150 µg/mL. …
Matched treatment: … , or convulsing) or gastric lavage, activated charcoal, cathartics, and general supportive measures ... diuresis and exchange transfusions are ineffective. (L1712) …
Matched description: … anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia] Binds to T-type voltage ... into excitable cells and are also involved in a variety of calcium-dependent processes, including ... division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium …

Matched symptoms: … to pulmonary edema, bloody sputum, and bronchial pneumonia. At high amounts, central nervous system ... depression may also occur, with symptoms such as weakness, dizziness, slow and shallow respiration ... , unconsciousness, and convulsions. Petroleum distillates are also irritating to the skin. (A594) …
Matched treatment: … Treatment is mainly symptomatic and supportive. Gastric lavage, emesis, and the administration of …
Matched description: … (Zingiber officinale) Cumene is the common name for isopropylbenzene, an organic compound that is ... an aromatic hydrocarbon. It is a constituent of crude oil and refined fuels. It is a flammable ... synthesis of other industrially important chemicals such as phenol and acetone. Isopropylbenzene has been shown to exhibit catabolic function (A7843). …