Tmic
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Displaying toxins 101 - 125 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D3592Proamanullin
54532-46-6
C39H54N10O11S
870.971 g/mol
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  • Amide
  • Amine
  • Fungal Toxin
  • Mycotoxin
  • Natural Compound
  • Organic Compound
The major toxic mechanism of amatoxins is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA...more
Number of Targets: 14
T3D1675Ethyl thiocyanate
542-90-5
C3H5NS
87.143 g/mol
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  • Cyanide Compound
  • Ether
  • Industrial/Workplace Toxin
  • Nitrile
  • Organic Compound
  • Pollutant
  • Synthetic Compound
Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more
Number of Targets: 39
T3D1148Manganese sulfide
18820-29-6
MnS
87.003 g/mol
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  • Food Toxin
  • Inorganic Compound
  • Manganese Compound
  • Natural Compound
  • Pollutant
Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more
Number of Targets: 5
T3D4042alpha-Solanine
20562-02-1
C45H73NO15
868.059 g/mol
Thumb
  • Amine
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Solanum glycoalkaloids can inhibit cholinesterase, disrupt cell membranes, and be teratogenic (cause birth defects). One study suggests that the toxic mechanism of sol...more
Number of Targets: 0
T3D19352,2',3,3',4,4',5,6,6'-Nonabromobiphenyl
60586-57-4
C12HBr9
864.272 g/mol
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  • Aromatic Hydrocarbon
  • Bromide Compound
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organobromide
  • Polybrominated Biphenyl
  • Synthetic Compound
The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more
Number of Targets: 1
T3D19362,2',3,3',4,5,5',6,6'-Nonabromobiphenyl
119264-63-0
C12HBr9
864.272 g/mol
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  • Aromatic Hydrocarbon
  • Bromide Compound
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organobromide
  • Polybrominated Biphenyl
  • Synthetic Compound
The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more
Number of Targets: 1
T3D19922,2',3,3',4,4',5,5',6-Nonabromobiphenyl
69278-62-2
C12HBr9
864.272 g/mol
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  • Aromatic Hydrocarbon
  • Bromide Compound
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organobromide
  • Polybrominated Biphenyl
  • Synthetic Compound
The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more
Number of Targets: 1
T3D2473Phallisacin
58286-46-7
C37H50N8O14S
862.903 g/mol
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  • Amide
  • Amine
  • Ether
  • Fungal Toxin
  • Mycotoxin
  • Natural Compound
  • Organic Compound
  • Phallotoxin
Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more
Number of Targets: 6
T3D499622,23-dihydroavermectin b1b
70209-81-3
C47H72O14
861.066 g/mol
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  • Antiparasitic Agent
  • Avermectin
  • Drug
  • Lachrymator
  • Metabolite
  • Synthetic Compound
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding c...more
Number of Targets: 14
T3D1135Manganese dioxide
1313-13-9
MnO2
86.937 g/mol
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  • Food Toxin
  • Household Toxin
  • Inorganic Compound
  • Manganese Compound
  • Natural Compound
  • Pollutant
Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more
Number of Targets: 5
T3D1738Lithium bromide
7550-35-8
BrLi
86.845 g/mol
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  • Bromide Compound
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Lithium Compound
  • Synthetic Compound
Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more
Number of Targets: 6
T3D2412Iron phosphide
12023-53-9
FeP
86.819 g/mol
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  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Phosphide
  • Synthetic Compound
Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to...more
Number of Targets: 20
T3D2403Hexane
110-54-3
C6H14
86.175 g/mol
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  • Adhesive
  • Food Toxin
  • Gasoline Additive/Component
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
  • Pollutant
  • Solvent
Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more
Number of Targets: 6
T3D24042-Methylpentane
107-83-5
C6H14
86.175 g/mol
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  • Gasoline Additive/Component
  • Industrial/Workplace Toxin
  • Organic Compound
  • Solvent
  • Synthetic Compound
Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more
Number of Targets: 4
T3D24053-Methylpentane
96-14-0
C6H14
86.175 g/mol
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  • Gasoline Additive/Component
  • Industrial/Workplace Toxin
  • Organic Compound
  • Solvent
  • Synthetic Compound
Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more
Number of Targets: 4
T3D24062,3-Dimethylbutane
79-29-8
C6H14
86.175 g/mol
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  • Gasoline Additive/Component
  • Industrial/Workplace Toxin
  • Organic Compound
  • Solvent
  • Synthetic Compound
Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more
Number of Targets: 4
T3D24072,2-Dimethylbutane
75-83-2
C6H14
86.175 g/mol
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  • Gasoline Additive/Component
  • Industrial/Workplace Toxin
  • Organic Compound
  • Solvent
  • Synthetic Compound
Hexane's toxicity is caused by it neurotoxic metabolite, 2,5-hexanedione. It damages the central and peripheral nervous system by causing axonal swelling and degenerat...more
Number of Targets: 4
T3D2562Gamma-Butyrolactone
96-48-0
C4H6O2
86.089 g/mol
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  • Ester
  • Ether
  • Food Toxin
  • Household Toxin
  • Indicator and Reagent
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Solvent
  • Synthetic Compound
Gamma-butyrolactone is rapidly converted to gamma-hydroxybutyrate. This may account for the subsequent central nervous system depressant. Gamma-butyrolactone is an ane...more
Number of Targets: 1
T3D3470Ethenyl acetate
108-05-4
C4H6O2
86.089 g/mol
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  • Cigarette Toxin
  • Ester
  • Food Toxin
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Lachrymator
  • Metabolite
  • Organic Compound
  • Pollutant
  • Synthetic Compound
One of the metabolites of vinyl acetate, acetaldehyde, is a known animal carcinogen. Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (L1304...more
Number of Targets: 1
T3D3241Diacetyl
431-03-8
C4H6O2
86.089 g/mol
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  • Animal Toxin
  • Food Toxin
  • Fragrance Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Ketone
  • Lachrymator
  • Metabolite
  • Natural Compound
  • Organic Compound
Diacetyl is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more
Number of Targets: 4
T3D1684Ferric hexacyanoferrate
14038-43-8
C18Fe7N18
859.228 g/mol
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  • Cyanide Compound
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Synthetic Compound
Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more
Number of Targets: 39
T3D1042Avermectin B1b
65195-56-4
C47H70O14
859.050 g/mol
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  • Avermectin
  • Bacterial Toxin
  • Ester
  • Ether
  • Lachrymator
  • Natural Compound
  • Organic Compound
  • Pesticide
It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more
Number of Targets: 11
T3D4019Paclitaxel
33069-62-4
C47H51NO14
853.906 g/mol
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  • Amine
  • Antineoplastic Agent, Phytogenic
  • Drug
  • Ester
  • Ether
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
  • Tubulin Modulator
Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arre...more
Number of Targets: 6
T3D4050alpha-Chaconine
20562-03-2
C45H73NO14
852.059 g/mol
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  • Amine
  • Food Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Alpha-Chaconine has inhibitory effect on lung adenocarcinoma cell metastasis in vitro. Alpha-chaconine could inhibit phosphorylation of c-Jun N-terminal kinase (JNK) a...more
Number of Targets: 0
T3D1290Boron arsenide
12005-69-5
AsB
85.733 g/mol
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  • Arsenic Compound
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Metal
  • Metalloid
  • Pollutant
  • Synthetic Compound
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more
Number of Targets: 44
Displaying toxins 101 - 125 of 3678 in total