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Displaying toxin 3401 - 3425 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D4765Tolazamide
1156-19-0
C14H21N3O3S
311.400 g/mol
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  • Amide
  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more
Number of Targets: 3
T3D2751Tolcapone
134308-13-7
C14H11NO5
273.241 g/mol
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  • Antidyskinetic
  • Antiparkinson Agent
  • Central Nervous System Agent
  • Drug
  • Enzyme Inhibitor
  • Ester
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Tolcapone hepatoxicity can be attributed to elevated levels of transminases, but studies have shown that minimal risk exists for those without preexisting liver condit...more
Number of Targets: 1
T3D0071Toluene
108-88-3
C7H8
92.138 g/mol
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  • Aromatic Hydrocarbon
  • Cosmetic Toxin
  • Food Toxin
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Pollutant
  • Solvent
Toluene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more
Number of Targets: 39
T3D1665Toluene diisocyanate
86-91-9
C18H12N4O4
348.312 g/mol
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  • Aromatic Hydrocarbon
  • Cyanide Compound
  • Household Toxin
  • Industrial/Workplace Toxin
  • Organic Compound
  • Pollutant
  • Synthetic Compound
  • Volatile Isocyanate
Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more
Number of Targets: 39
T3D1653Toluenesulfonylmethyl isocyanide
36635-61-7
C9H9NO2S
195.238 g/mol
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  • Aromatic Hydrocarbon
  • Cyanide Compound
  • Ether
  • Industrial/Workplace Toxin
  • Organic Compound
  • Pollutant
  • Synthetic Compound
Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more
Number of Targets: 39
T3D2733Topiramate
97240-79-4
C12H21NO8S
339.362 g/mol
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  • Anti-Obesity Agent
  • Anticonvulsant
  • Drug
  • Food Toxin
  • Metabolite
  • Neuroprotective Agent
  • Organic Compound
  • Synthetic Compound
The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustain...more
Number of Targets: 9
T3D0031Toxaphene
8001-35-2
C10H8Cl8
411.795 g/mol
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  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
Toxaphene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more
Number of Targets: 52
T3D3099Toxiferine
6888-23-9
C40H46Cl2N4O2
685.725 g/mol
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  • Amine
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256)
Number of Targets: 16
T3D2597Toxin A (Clostridium difficile)
Not Available
Not Available
308052.765 g/mol
T3d2597
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more
Number of Targets: 20
T3D2598Toxin B (Clostridium difficile)
Not Available
Not Available
269709.285 g/mol
T3d2598
  • Amide
  • Amine
  • Bacterial Toxin
  • Natural Compound
  • Organic Compound
  • Protein
Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more
Number of Targets: 20
T3D3714Toxin T2 tetrol
34114-99-3
C15H22O6
298.332 g/mol
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  • Ether
  • Food Toxin
  • Fungal Toxin
  • Lachrymator
  • Metabolite
  • Mycotoxin
  • Natural Compound
  • Organic Compound
Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more
Number of Targets: 2
T3D3935Tralkoxydim
87820-88-0
C20H27NO3
329.433 g/mol
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  • Ester
  • Ether
  • Herbicide
  • Organic Compound
  • Pesticide
  • Synthetic Compound
Tralkoxydim is structurally a cyclohexanedione, but because it does not appear to produce a toxic metabolite produced by other substances, the EPA has not assumed that...more
Number of Targets: 5
T3D1852Tralomethrin
66841-25-6
C22H19Br4NO3
665.007 g/mol
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  • Bromide Compound
  • Ester
  • Ether
  • Household Toxin
  • Nitrile
  • Organic Compound
  • Organobromide
  • Pesticide
  • Pyrethroid
  • Synthetic Compound
Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more
Number of Targets: 20
T3D2575Tramadol
27203-92-5
C16H25NO2
263.375 g/mol
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  • Amine
  • Analgesic
  • Analgesic, Opioid
  • Drug
  • Ether
  • Metabolite
  • Narcotic
  • Organic Compound
  • Synthetic Compound
Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both posi...more
Number of Targets: 9
T3D0173trans-1,2-Dichloroethene
156-60-5
C2H2Cl2
96.943 g/mol
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  • Industrial/Workplace Toxin
  • Lachrymator
  • Organic Compound
  • Organochloride
  • Pollutant
  • Solvent
  • Synthetic Compound
Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids a...more
Number of Targets: 4
T3D1907trans-1,3-Dichloropropene
10061-02-6
C3H4Cl2
110.970 g/mol
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  • Chloropropene
  • Food Toxin
  • Lachrymator
  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
The primary toxic effects of trans-1,3-dichloropropene are portal-of-entry effects resulting from the chemical reactivity of the compound and its physicochemical prope...more
Number of Targets: 3
T3D0064trans-Chlordane
5103-74-2
C10H6Cl8
409.779 g/mol
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  • Organic Compound
  • Organochloride
  • Pesticide
  • Synthetic Compound
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r...more
Number of Targets: 14
T3D4889trans-Cinnamic acid
140-10-3
C9H8O2
148.159 g/mol
Thumb
  • Ester
  • Food Toxin
  • Household Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Plant Toxin
Not Available
Number of Targets: 1
T3D1586trans-Diamminedichloro-palladium(II)
13782-33-7
Cl2H4N2Pd
209.370 g/mol
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  • Amine
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Organic Compound
  • Organometallic
  • Palladium Compound
  • Synthetic Compound
Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more
Number of Targets: 6
T3D1588trans-Diamminedinitro-palladium(II)
28068-05-5
H8N4O4Pd
234.510 g/mol
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  • Amine
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Nitrite
  • Organic Compound
  • Organometallic
  • Palladium Compound
  • Synthetic Compound
Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more
Number of Targets: 6
T3D1394trans-Dichlorobis(ethylenediamine)cobalt(III) chloride
14040-33-6
C4H16Cl3CoN4
285.489 g/mol
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  • Amine
  • Cobalt Compound
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organometallic
  • Pollutant
  • Synthetic Compound
Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more
Number of Targets: 35
T3D1587trans-Dichlorobis-(triphenylphosphine) palladium(II)
965-03-2
C36H32Cl2P2Pd
703.910 g/mol
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  • Aromatic Hydrocarbon
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organometallic
  • Palladium Compound
  • Synthetic Compound
Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more
Number of Targets: 6
T3D2881Tranylcypromine
155-09-9
C9H11N
133.190 g/mol
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  • Amine
  • Anti-Anxiety Agent
  • Antidepressant
  • Antidepressive Agent
  • Drug
  • Metabolite
  • Monoamine Oxidase Inhibitor
  • Organic Compound
  • Synthetic Compound
Tranylcypromine irreversibly and nonselectively inhibits monoamine oxidase (MAO). Within neurons, MAO appears to regulate the levels of monoamines released upon synapt...more
Number of Targets: 4
T3D2852Trazodone
19794-93-5
C19H22ClN5O
371.864 g/mol
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  • Amine
  • Anti-Anxiety Agent
  • Antidepressant, Second-Generation
  • Antidepressive Agent, Second-Generation
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Serotonin Uptake Inhibitor
  • Synthetic Compound
Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's antidepressant ac...more
Number of Targets: 15
T3D0793Tremolite Asbestos
77536-68-6
(Na, K)0-1Ca2Mg5Si8O22(OH)2
Not Available
T3d0793
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Mineral
  • Natural Compound
  • Pollutant
When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe...more
Number of Targets: 1
Displaying toxin 3401 - 3425 of 3678 in total