Browsing Toxins By Category
T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
---|---|---|---|---|---|
T3D4936 | Allantoin 97-59-6 | C4H6N4O3 158.115 g/mol |
| Not Available Number of Targets: 2 | |
T3D4471 | Succinylacetone 51568-18-4 | C7H10O4 158.152 g/mol |
| Not Available Number of Targets: 1 | |
T3D4257 | Oxoadipic acid 3184-35-8 | C6H8O5 160.125 g/mol |
| In the matrix of mitochondria, 2-oxoadipate is decarboxylated to glutaryl-CoA by the 2-oxoadipate dehydrogenase complex and then converted to acetyl-CoA. Accumulation ...more Number of Targets: 1 | |
T3D4259 | Aminoadipic acid 542-32-5 | C6H11NO4 161.156 g/mol |
| Not Available Number of Targets: 4 | |
T3D4258 | 2-Hydroxyadipic acid 18294-85-4 | C6H10O5 162.141 g/mol |
| 2-Hydroxyadipic acid is a hydroxy-dicarboxylic acid formed by the reduction of 2-ketoadipic acid. Deficiency of 2-ketoadipic dehydrogenase causes 2-ketoadipic acidemia...more Number of Targets: 0 | |
T3D4262 | 3-Hydroxymethylglutaric acid 503-49-1 | C6H10O5 162.141 g/mol |
| Not Available Number of Targets: 1 | |
T3D0302 | Arsenocholine 39895-81-3 | C5H14AsO 165.085 g/mol |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 | |
T3D4366 | L-Phenylalanine 63-91-2 | C9H11NO2 165.189 g/mol |
| Extremely high serum levels of phenylalanine are found in patients with the inborn error of metabolism (IEM) called Phenylketonuria (PKU). At pathological concentratio...more Number of Targets: 10 | |
T3D4287 | Homogentisic acid 451-13-8 | C8H8O4 168.147 g/mol |
| Extremely high levels of homogentisic acid are found in patients with the inborn error of metabolism (IEM) called Alkaptonuria. Homogentisic acid spontaneously undergo...more Number of Targets: 0 | |
T3D3958 | Diethylthiophosphate 5871-17-0 | C4H11O3PS 170.167 g/mol |
| Diethylthiophosphate (DETP) induces DNA damage only in the hepatic cell lines, and this effect could be related to a secondary non-diffusible metabolite generated by t...more Number of Targets: 1 | |
T3D4773 | Capric acid 334-48-5 | C10H20O2 172.265 g/mol |
| It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more Number of Targets: 4 | |
T3D4959 | Pyrophosphate 14000-31-8 | O7P2 173.946 g/mol |
| Not Available Number of Targets: 0 | |
T3D4289 | L-Arginine 74-79-3 | C6H14N4O2 174.201 g/mol |
| Many of supplemental L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO....more Number of Targets: 9 | |
T3D4310 | N-Acetyl-L-aspartic acid 997-55-7 | C6H9NO5 175.139 g/mol |
| The primary proposed functions of N-acetylaspartic acid include: 1) A neuronal osmolyte that is involved in fluid balance in the brain; 2) a source of acetate for lipi...more Number of Targets: 0 | |
T3D4295 | Citrulline 372-75-8 | C6H13N3O3 175.186 g/mol |
| L-citrulline is converted to L-arginine by argininosuccinate synthase. L-arginine is in turn responsible for citrulline's therapeutic affects. Many of L-arginine's act...more Number of Targets: 13 | |
T3D3956 | Cotinine 486-56-6 | C10H12N2O 176.215 g/mol |
| Not Available Number of Targets: 1 | |
T3D0301 | Arsenobetaine 64436-13-1 | C5H11AsO2 178.061 g/mol |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 | |
T3D4356 | D-Glucose 50-99-7 | C6H12O6 180.156 g/mol |
| Very high serum levels of glucose are found in untreated diabetic (type I or type II) patients. Glucose in chronic excess causes toxic effects on the structure and fun...more Number of Targets: 33 | |
T3D4345 | D-Fructose 53188-23-1 | C6H12O6 180.156 g/mol |
| Fructose is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the generation of uric acid. Uric acid is generate...more Number of Targets: 5 | |
T3D4201 | Caffeic acid 331-39-5 | C9H8O4 180.157 g/mol |
| Not Available Number of Targets: 1 | |
T3D4371 | L-Tyrosine 60-18-4 | C9H11NO3 181.189 g/mol |
| Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the...more Number of Targets: 5 | |
T3D4966 | 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid 3247-75-4 | C9H10O4 182.173 g/mol |
| Not Available Number of Targets: 0 | |
T3D3961 | Monoethyl phthalate 2306-33-4 | C10H10O4 194.184 g/mol |
| Not Available Number of Targets: 3 | |
T3D4991 | 9-Hydroxyphenanthrene 484-17-3 | C14H10O 194.229 g/mol |
| 9-phenanthrol is a recently identified inhibitor of the transient receptor potential melastatin (TRPM) 4 channel, a Ca(2+) -activated non-selective cation channel whos...more Number of Targets: 0 | |
T3D4967 | L-Dopaquinone 110810-88-3 | C9H9NO4 195.172 g/mol |
| Not Available Number of Targets: 0 |