Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3965 | O-Desmethylangolensin 21255-69-6 | C15H14O4 258.269 g/mol |  |
| O-desmethylangolensin (ODMA) exerts androgen receptor antagonistic activity and agonistic activity towards estrogen receptor (ER)-α and ERβ. The structure of ODMA is s...more Number of Targets: 2 |
| T3D3967 | Enterolactone 76543-15-2 | C18H18O4 298.333 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D3968 | 1-Naphthol 90-15-3 | C10H8O 144.170 g/mol |  |
| 1-Naphthol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 5 |
| T3D3971 | 1-Hydroxypyrene 5315-79-7 | C16H12O 220.266 g/mol |  |
| Not Available Number of Targets: 15 |
| T3D3973 | Monoethylhexyl phthalic acid 4376-20-9 | C16H22O4 278.344 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D4023 | Neosaxitoxin 64296-20-4 | C10H17N7O5 315.286 g/mol |  |
| Neosaxitoxin (NSTX) blocks the extracellular portion, the outer vestibule, of some voltage gated sodium channels in a very powerful and reversible manner, without affe...more Number of Targets: 0 |
| T3D4029 | Okadaic acid 78111-17-8 | C44H68O13 805.003 g/mol |  |
| Okadaic acid (OA) dramatically increases both nerve growth factor (NGF) mRNA content (50-fold) and NGF secretion (100-fold) in astrocytes. Okadaic acid also activated ...more Number of Targets: 1 |
| T3D4030 | Dinophysistoxin 1 81720-10-7 | C45H70O13 819.030 g/mol |  |
| Dinophysistoxin 1 (DTX1) is the analogue of okadaic acid causing diarrheic shellfish poisoning (DSP) in humans shortly after the ingestion of contaminated seafood. DTX...more Number of Targets: 0 |
| T3D4038 | Gonyautoxin I 60748-39-2 | C10H17N7O9S 411.348 g/mol |  |
| The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of N...more Number of Targets: 0 |
| T3D4039 | Gonyautoxin II 60508-89-6 | C10H17N7O8S 395.349 g/mol |  |
| The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of N...more Number of Targets: 0 |
| T3D4040 | Domoic acid 14277-97-5 | C15H21NO6 311.330 g/mol |  |
| Domoic acid acts as a neurotoxin. It induces excitotoxicity by an integrative action on ionotropic glutamate receptors at both sides of the synapse for which it has hi...more Number of Targets: 1 |
| T3D4051 | Gymnodimine 173792-58-0 | C32H45NO4 507.704 g/mol |  |
| Gymnodimine exerts its toxic effects via binding to nicotinic acetylcholine receptors with picomolar affinities with no sign of apparent reversibility in short time fr...more Number of Targets: 0 |
| T3D4056 | Debromoaplysiatoxin 52423-28-6 | C32H48O10 592.718 g/mol |  |
| Debromoaplysiatoxin have the ability to evoke biological and biochemical responses in cells, and belong to the TPA (12-O-tetradecanoylphorbol 13-acetate) type tumor pr...more Number of Targets: 0 |
| T3D4128 | Brevetoxin B 79580-28-2 | C50H70O14 895.082 g/mol |  |
| Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness c...more Number of Targets: 1 |
| T3D4201 | Caffeic acid 331-39-5 | C9H8O4 180.157 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4202 | Carbamic acid 463-77-4 | CH3NO2 61.040 g/mol |  |
| Carbamic acid is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholine...more Number of Targets: 1 |
| T3D4214 | Diethylamine 71247-25-1 | C4H11N 73.137 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4237 | Fumaric acid 110-17-8 | C4H4O4 116.072 g/mol |  |
| Acute Toxicity: Fumarate is also an endogenous electrophile and reacts spontaneously with cysteine residues in proteins by a Michael addition reaction to form S-(2-suc...more Number of Targets: 17 |
| T3D4240 | Androstenedione 63-05-8 | C19H26O2 286.409 g/mol |  |
| Androstenedione is converted to testosterone and estrogen, and when taken in sufficient quantities androstenedione can cause unwanted masculinizing and feminizing effe...more Number of Targets: 11 |
| T3D4242 | Dehydroepiandrosterone sulfate 651-48-9 | C19H28O5S 368.488 g/mol |  |
| Although it predominantly functions as an endogenous precursor to more potent androgens such as testosterone and dihydroxytestosterone, DHEA (which is produced from DH...more Number of Targets: 0 |
| T3D4245 | Deoxycorticosterone 64-85-7 | C21H30O3 330.461 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D4247 | L-2-Hydroxyglutaric acid 13095-48-2 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4250 | Gamma-Aminobutyric acid 56-12-2 | C4H9NO2 103.120 g/mol |  |
| Not Available Number of Targets: 10 |
| T3D4251 | D-2-Hydroxyglutaric acid 2889-31-8 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4253 | L-Lactic acid 79-33-4 | C3H6O3 90.078 g/mol |  |
| Accumulation of L-lactic acid in the body has been shown to be toxic. At times of lactic acidosis, when excess intracellular lactate is released into the blood, mainte...more Number of Targets: 1 |