Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2610 | Alpha-hemolysin 94716-94-6 | Not Available 35904.070 g/mol |  |
| Alpha-hemolysin consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of...more Number of Targets: 0 |
| T3D2611 | Beta-hemolysin 143257-99-2 | Not Available 37237.665 g/mol |  |
| Hemolysins consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of mono...more Number of Targets: 0 |
| T3D2612 | Delta-hemolysin 74838-20-3 | Not Available 2978.515 g/mol |  |
| Hemolysins consists mainly of beta-sheets forms heptameric units on the cellular membrane, producing a complete beta-barrel pore. This pore allows the exchange of mono...more Number of Targets: 0 |
| T3D2613 | Leukocidin S Not Available | Not Available 35556.550 g/mol |  |
| Leukocidin S and leukocidin F act together as subunits, assembling in the membrane of host defense cells, particularly white blood cells, monocytes and macrophages. Th...more Number of Targets: 0 |
| T3D2614 | Leukocidin F 147096-70-6 | Not Available 36566.730 g/mol |  |
| Leukocidin S and leukocidin F act together as subunits, assembling in the membrane of host defense cells, particularly white blood cells, monocytes and macrophages. Th...more Number of Targets: 0 |
| T3D2618 | Enterotoxin type A Not Available | Not Available 29669.310 g/mol |  |
| The action of enterotoxins leads to increased chloride ion permeability of the apical membrane of intestinal mucosal cells. These membrane pores are activated by eithe...more Number of Targets: 0 |
| T3D2619 | Enterotoxin type B Not Available | Not Available 31435.675 g/mol |  |
| The action of enterotoxins leads to increased chloride ion permeability of the apical membrane of intestinal mucosal cells. These membrane pores are activated by eithe...more Number of Targets: 0 |
| T3D2620 | Pneumolysin Not Available | Not Available 52898.050 g/mol |  |
| Pneumolysin binds to cholesterol the undergoes oligomerization and membrane pore formation. Pneumolysin also activates the classical pathway of complement. Mutational ...more Number of Targets: 1 |
| T3D2622 | Streptolysin O (Streptococcus pyogenes) 98072-47-0 | Not Available 63637.990 g/mol |  |
| Streptolysin O binds to cholesterol on eukaryotic cell membranes, then is able to lyse them. (T170) Number of Targets: 1 |
| T3D2623 | Cholera toxin 9012-63-9 | Not Available 29335.385 g/mol |  |
| The effect is dependent on a specific receptor, monosialosyl ganglioside (GM1 ganglioside) present on the surface of intestinal mucosal cells. Once it has entered the ...more Number of Targets: 2 |
| T3D2624 | Melittin (Apis mellifera) 20449-79-0 | Not Available 7584.775 g/mol |  |
| Melittin has strong haemolytic activity. It integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged p...more Number of Targets: 12 |
| T3D2625 | Lopap Not Available | Not Available 22432.280 g/mol |  |
| Lopap activates thrombin by cleavage of prothrombin, causing thrombus formation, fibrinogen depletion, uncoagulable blood, decreased platelet count, inhibition of coll...more Number of Targets: 0 |
| T3D2627 | mu-Agatoxin 120500-28-9 | Not Available 4272.715 g/mol |  |
| mu-Agatoxins modify presynaptic voltage-activated sodium channels in the neuromuscular joints of insects. Modifying sodium channels leads to an increased sensitivity o...more Number of Targets: 0 |
| T3D2628 | kappa-Atracotoxin (Hadronyche versuta) Not Available | Not Available 3685.155 g/mol |  |
| kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) Number of Targets: 0 |
| T3D2629 | Hanatoxin 170780-01-5 | Not Available 4120.690 g/mol |  |
| Hanatoxin inhibits voltage-gated potassium channels by altering the gating energetics, which it does by occupying multiple binding sites on the channel. It can also in...more Number of Targets: 3 |
| T3D2630 | Sphingomyelinase D (Loxosceles intermedia) 9031-54-3 | Not Available 34158.125 g/mol |  |
| Sphingomyelinase D catalyzes the hydrolysis of sphingomyelin, inducing complement-dependent haemolysis, dermonecrosis, blood vessel permeability and platelet aggregati...more Number of Targets: 0 |
| T3D2631 | Heteroscodratoxin Not Available | Not Available 4003.400 g/mol |  |
| Heteroscodratoxin inhibits voltage-gated potassium channels by binding to the extracellular linker of the channel and shifting activation of the channel to more depola...more Number of Targets: 5 |
| T3D2633 | Acanthophin 126601-49-8 | Not Available 8386.795 g/mol | |
| Acanthophin produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. It does this by binding to certain muscular and neuronal nic...more Number of Targets: 8 |
| T3D2635 | Erabutoxin 59536-69-5 | Not Available 9136.510 g/mol |  |
| Erabutoxin binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. This produces peripheral ...more Number of Targets: 6 |
| T3D2636 | Disintegrin echistatin (Echis carinatus) Not Available | Not Available 5424.090 g/mol |  |
| Disintegrins work by countering blood clotting steps, inhibiting the clumping of platelets. They inhibit fibrinogen interaction with platelet receptors expressed on gl...more Number of Targets: 2 |
| T3D2637 | Nigroxin 9001-84-7 | Not Available 13341.125 g/mol |  |
| Nigroxin is myotoxic. (T170) Number of Targets: 0 |
| T3D2638 | Notexin 37233-96-4 | Not Available 13593.310 g/mol |  |
| Notexin is myotoxic and inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. (T170) Number of Targets: 0 |
| T3D2639 | Ohanin Not Available | Not Available 21173.945 g/mol | |
| Ohanin is extremely neurotoxic, cardiotoxic, and cytotoxic. (L1102) Number of Targets: 0 |
| T3D2640 | Pseudechetoxin Not Available | Not Available 26474.445 g/mol |  |
| Pseudechetoxin blocks olfactory and retinal cyclic nucleotide-gated (CNG) ion channel currents. It forms high-affinity contacts with the pore turret region and most li...more Number of Targets: 2 |
| T3D2642 | Viperotoxin Not Available | Not Available 15554.775 g/mol |  |
| Viperotoxin is a presynaptic neurotoxin. (T170) Number of Targets: 0 |