Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D2505 | Heteropodatoxin 189120-72-7 | Not Available 3917.380 g/mol |  |
| Heteropodatoxin blocks A-type, transient voltage-gated potassium channels by acting as a gating modifier. As a result, a larger depolarization is needed to open the ch...more Number of Targets: 3 |
| T3D2631 | Heteroscodratoxin Not Available | Not Available 4003.400 g/mol |  |
| Heteroscodratoxin inhibits voltage-gated potassium channels by binding to the extracellular linker of the channel and shifting activation of the channel to more depola...more Number of Targets: 5 |
| T3D4286 | Hexacosanoic acid 506-46-7 | C26H52O2 396.690 g/mol |  |
| Adrenoleukodystrophy (ALD) is caused by mutations in ABCD1, a gene located on the X chromosome that codes for ALD, a peroxisomal membrane transporter protein. The exac...more Number of Targets: 0 |
| T3D2528 | Histrionicotoxin 34272-51-0 | C19H25NO 283.408 g/mol |  |
| Histrionicotoxin is a potent non-competitive antagonist of nicotinic acetylcholine receptors. (L1072) Number of Targets: 16 |
| T3D2492 | Holocyclotoxin 88254-04-0 | Not Available 7834.125 g/mol |  |
| Holocyclotoxin produces paralysis by acting at the neuromuscular junction. (A2834) Number of Targets: 0 |
| T3D4287 | Homogentisic acid 451-13-8 | C8H8O4 168.147 g/mol |  |
| Extremely high levels of homogentisic acid are found in patients with the inborn error of metabolism (IEM) called Alkaptonuria. Homogentisic acid spontaneously undergo...more Number of Targets: 0 |
| T3D2581 | Hongotoxin 203526-59-4 | Not Available 4226.080 g/mol |  |
| Hongotoxin inhibits voltage-gated potassium channels. (L1049) Number of Targets: 4 |
| T3D2499 | Huwentoxin 526224-73-7 | Not Available 9318.830 g/mol |  |
| Huwentoxin blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor, which affects the release of neurotransmitters from autonomic nerve en...more Number of Targets: 17 |
| T3D2646 | Hydralysin (Chlorohydra viridissima) Not Available | Not Available 26212.075 g/mol |  |
| Hydralysin is a cytolytic toxin. It binds to erythrocyte membranes and has weak hemolytic activity, probably mediated by oligomerization and pore formation. (T170) Number of Targets: 0 |
| T3D4304 | Hydroxypropionic acid 503-66-2 | C3H6O3 90.078 g/mol |  |
| 3-hydroxypropionic acid (3HP) toxicity is mediated by 3-hydroxypropionic aldehyde (reuterin). 3HP toxicity is also proposed to be related to inhibition of the chorisma...more Number of Targets: 0 |
| T3D2512 | Iberiotoxin 129203-60-7 | Not Available 4253.920 g/mol |  |
| Iberiotoxin binds to the outer face of the large-conductance calcium-activated potassium channels with high affinity. It selectively inhibits the current by decreasin...more Number of Targets: 5 |
| T3D2514 | Imperatoxin-1 Not Available | Not Available 18663.670 g/mol | |
| Imperatoxin-I is an inhibitor which decreases the influx of Ca2+ from the sarcoplasmatic reticulum into the cell. Imperatoxin-I acts on the Ryanodine receptors (RyR), ...more Number of Targets: 3 |
| T3D2513 | Imperatoxin-A 172451-37-5 | Not Available 3764.370 g/mol |  |
| Imperatoxin-A is an activator which enhances the influx of Ca2+ from the sarcoplasmatic reticulum into the cell. Imperatoxin-A acts on the Ryanodine receptors (RyR), w...more Number of Targets: 3 |
| T3D3514 | Infliximab 170277-31-3 | Not Available 36105.695 g/mol |  |
| Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with i...more Number of Targets: 3 |
| T3D2477 | Insulin 11061-68-0 | Not Available 11980.795 g/mol |  |
| Insulin has a direct inhibitory effect on the lipase concerned with the mobilization of fattty acids. Insulin binds to a receptor on the surface of the target cell and...more Number of Targets: 56 |
| T3D2515 | Kaliotoxin 145199-73-1 | Not Available 6461.905 g/mol |  |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2516 | Kaliotoxin-1 150769-72-5 | Not Available 4155.975 g/mol |  |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2517 | Kaliotoxin-2 159605-22-8 | Not Available 6392.840 g/mol | |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2518 | Kaliotoxin-3 223246-26-2 | Not Available 4027.840 g/mol | |
| Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affectin...more Number of Targets: 6 |
| T3D2628 | kappa-Atracotoxin (Hadronyche versuta) Not Available | Not Available 3685.155 g/mol |  |
| kappa-Atracotoxins inhibit insect voltage-gated potassium channels. (T170, L1812) Number of Targets: 0 |
| T3D2659 | kappa-Conotoxin (Conus purpurascens) Not Available | Not Available 8316.795 g/mol |  |
| kappa-Conotoxins inhibit potassium channels. (L1107) Number of Targets: 23 |
| T3D2511 | kappa-Hefutoxin 478621-50-0 | Not Available 2659.865 g/mol |  |
| kappa-Hefutoxin blocks voltage-gated potassium channels and also slows down their activation kinetics. (L1048) Number of Targets: 2 |
| T3D4426 | Ketoleucine 816-66-0 | C6H10O3 130.142 g/mol |  |
| Ketoleucine is a metabolite that accumulates in Maple Syrup Urine Disease (MSUD) and shown to compromise brain energy metabolism by blocking the respiratory chain. Number of Targets: 0 |
| T3D2519 | Kurtoxin 820959-57-7 | Not Available 7394.400 g/mol |  |
| Kurtoxin affects the gating of voltage-gated sodium channels and calcium channels. In calcium channels Kurtoxin binds close to the channel voltage sensor and thereby p...more Number of Targets: 14 |