Browsing Toxins
Displaying toxin 3076 - 3100 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3018 | Rifapentine 61379-65-5 | C47H64N4O12 877.031 g/mol |  |
| Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifape...more Number of Targets: 0 |
| T3D2875 | Riluzole 1744-22-5 | C8H5F3N2OS 234.198 g/mol |  |
| The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on...more Number of Targets: 5 |
| T3D4535 | Rimsulfuron 122931-48-0 | C14H17N5O7S2 431.444 g/mol |  |
| Not Available Number of Targets: 13 |
| T3D2668 | Risedronate 105462-24-6 | C7H11NO7P2 283.112 g/mol |  |
| The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farn...more Number of Targets: 3 |
| T3D2871 | Risperidone 106266-06-2 | C23H27FN4O2 410.485 g/mol |  |
| Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and sp...more Number of Targets: 32 |
| T3D2671 | Rituximab 174722-31-7 | Not Available 36105.695 g/mol |  |
| Binds to the CD20 antigen which is found on mature B lymphocytes. The Fc domain recruits immune effector functions to mediate B-cell lysis. The antibody appears to ind...more Number of Targets: 12 |
| T3D2940 | Rizatriptan 145202-66-0 | C15H19N5 269.345 g/mol |  |
| Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT1D receptors, which serves t...more Number of Targets: 7 |
| T3D2497 | Robustoxin 91728-12-0 | Not Available 4856.685 g/mol |  |
| Robustoxin inhibits both insect and mammalian voltage-gated sodium channels. It binds to site 3 in tetrodotoxin-sensitive sodium channels, which slows their inactivati...more Number of Targets: 14 |
| T3D2731 | Ropinirole 91374-21-9 | C16H24N2O 260.375 g/mol |  |
| Ropinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is beli...more Number of Targets: 18 |
| T3D2741 | Ropivacaine 84057-95-4 | C17H26N2O 274.401 g/mol |  |
| Local anesthetics such as Ropivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in th...more Number of Targets: 1 |
| T3D3662 | Roquefortine 58735-64-1 | C22H23N5O2 389.450 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 23 |
| T3D3709 | Roridin A 14729-29-4 | C29H40O9 532.623 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3710 | Roridin D 14682-29-2 | C29H38O9 530.607 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3711 | Roridin E 16891-85-3 | C29H38O8 514.607 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D2680 | Rosuvastatin 287714-41-4 | C22H28FN3O6S 481.538 g/mol |  |
| Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in chole...more Number of Targets: 3 |
| T3D0800 | Rotenone 83-79-4 | C20H18O6 354.353 g/mol |  |
| Rotenone works by interfering with the electron transport chain in mitochondria. Specifically, it inhibits the transfer of electrons from iron-sulfur centers in comple...more Number of Targets: 47 |
| T3D0311 | Roxarsone 121-19-7 | C6H6AsNO6 263.037 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1750 | Rubidium bromide 7789-39-1 | BrRb 165.372 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D3573 | Rubidium nitrate 13126-12-0 | NO3Rb 147.473 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D3731 | Rubratoxin A 22467-31-8 | C26H32O11 520.526 g/mol |  |
| Rubratoxin A is a potent inhibitor of protein phosphatase 2A, exerting antitumor and antimetastatic effects. Inhibition may cause the phosphorylation of CREB and subse...more Number of Targets: 12 |
| T3D3730 | Rubratoxin B 21794-01-4 | C26H30O11 518.510 g/mol |  |
| Rubratoxin B is cytotoxic, hinders cell proliferation, and induces apoptosis. It also inhibits the activity of matrix metalloproteinase-2 and -9. Rubratoxin B causes d...more Number of Targets: 20 |
| T3D4066 | Ryanodine 15662-33-6 | C25H35NO9 493.547 g/mol |  |
| Ryanodine has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells....more Number of Targets: 1 |
| T3D0141 | S,S,S-Tributyl phosphorotrithioate 78-48-8 | C12H27OPS3 314.511 g/mol |  |
| S,S,S-Tributyl phosphorotrithioate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the ac...more Number of Targets: 17 |
| T3D4455 | S-Adenosylhomocysteine 979-92-0 | C14H20N6O5S 384.411 g/mol |  |
| Not Available Number of Targets: 17 |
| T3D4456 | S-Adenosylmethionine 29908-03-0 | C15H23N6O5S 399.445 g/mol |  |
| S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a c...more Number of Targets: 10 |