Browsing Toxins
Displaying toxin 3126 - 3150 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1519 | Aluminium phosphate 7784-30-7 | AlO4P 121.953 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1646 | Sodium metavanadate 13718-26-8 | NaO3V 121.930 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D1629 | Vanadium(II) chloride 10580-52-6 | Cl2V 121.848 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D0219 | Antimony 7440-36-0 | Sb 121.760 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D4218 | 2,6-Dimethylaniline 87-62-7 | C8H11N 121.180 g/mol |  |
| Treatment of AS52 cells with N-OH-2,6-dimethylaniline (2,6-DMA) and 2,6-DMAP led to intracellular production of reactive oxygen species (ROS). DNA strand breaks were o...more Number of Targets: 1 |
| T3D4156 | L-Cysteine 52-90-4 | C3H7NO2S 121.158 g/mol |  |
| Uremic toxins such as cysteine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulat...more Number of Targets: 20 |
| T3D1774 | Allyl bromide 106-95-6 | C3H5Br 120.976 g/mol |  |
| Organobromide compounds such as allylbromide are strong alkylating agents. Consequently they can readily modify free thiols (cysteines) and methionine residues of the...more Number of Targets: 3 |
| T3D1553 | Chlorodiethyaluminum 96-10-6 | C4H10AlCl 120.557 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D2851 | Magnesium Sulfate 7487-88-9 | MgO4S 120.368 g/mol |  |
| Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with reg...more Number of Targets: 6 |
| T3D4877 | 1,2,4-Trimethylbenzene 95-63-6 | C9H12 120.192 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D3468 | Isopropylbenzene 98-82-8 | C9H12 120.192 g/mol |  |
| Petroleum distillates are central nervous system depressants and cause pulmonary damage. (A600) Number of Targets: 0 |
| T3D4805 | Phenylacetaldehyde 122-78-1 | C8H8O 120.149 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0305 | Trimethylarsine 593-88-4 | C3H9As 120.025 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0011 | Chloroform 67-66-3 | CHCl3 119.378 g/mol |  |
| Chloroform and the reactive intermediates of chloroform metabolism, especially phosgene, bind covalently and irreversibly to cellular macromolecules and cause cellular...more Number of Targets: 41 |
| T3D1659 | Phenyl isocyanate 103-71-9 | C7H5NO 119.121 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D4368 | L-Threonine 72-19-5 | C4H9NO3 119.119 g/mol |  |
| L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver. May help combat mental illness and ...more Number of Targets: 3 |
| T3D3724 | Bovinocidin 504-88-1 | C3H5NO4 119.076 g/mol |  |
| 3-Nitropropionic acid is a suicide inhibitor of succinate dehydrogenase, an enzyme required for the activity of the tricarboxylic acid (TCA) cycle as well as mitochond...more Number of Targets: 4 |
| T3D1748 | Potassium bromide 7758-02-3 | BrK 119.002 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D0655 | Cobalt(II) carbonate 513-79-10 | CCoO3 118.942 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D0796 | Tin 7440-31-5 | Sn 118.710 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 15 |
| T3D0686 | Nickel carbonate 3333-67-3 | CNiO3 118.702 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D3082 | beta-Methylamino-L-alanine 15920-93-1 | C4H10N2O2 118.134 g/mol |  |
| BMAA may cause neurotoxic effects by damaging cells (such as neurons) in the motor cortex and spinal cord. (L1241) Number of Targets: 0 |
| T3D4263 | 3-Hydroxyisovaleric acid 625-08-1 | C5H10O3 118.131 g/mol |  |
| 3-Hydroxyisovaleric acid is a normal human metabolite excreted in the urine. Elevated levels of this compound are found in several disorders due to impairment of renal...more Number of Targets: 0 |
| T3D4404 | Methylmalonic acid 516-05-2 | C4H6O4 118.088 g/mol |  |
| Methylmalonic acid is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This me...more Number of Targets: 0 |
| T3D4453 | Succinic acid 110-15-6 | C4H6O4 118.088 g/mol |  |
| Succinate can inhibit the activities of α-KG–dependent oxygenases (KDMs) and the TET family of 5-methlycytosine (5mC) hydroxylases. Succinate also mediates allosteric ...more Number of Targets: 41 |