Displaying toxin 3401 - 3425 of 3678 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D4703Metronidazole
443-48-1
C6H9N3O3
171.154 g/mol
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  • Amine
  • Anti-Infective Agent
  • Antiprotozoal Agent
  • Drug
  • Household Toxin
  • Metabolite
  • Organic Compound
  • Radiation-Sensitizing Agent
  • Synthetic Compound
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form...more
Number of Targets: 1
T3D4705Nitrilotriacetic Acid
139-13-9
C6H9NO6
191.139 g/mol
Thumb
  • Amine
  • Industrial/Workplace Toxin
  • Organic Compound
  • Synthetic Compound
Not Available
Number of Targets: 2
T3D4707Phenacetin
62-44-2
C10H13NO2
179.216 g/mol
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  • Amide
  • Amine
  • Analgesic, Non-Narcotic
  • Drug
  • Ether
  • Organic Compound
  • Synthetic Compound
Phenacetin's analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it ...more
Number of Targets: 1
T3D4708Phenolphthalein
77-09-8
C20H14O4
318.323 g/mol
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  • Drug
  • Ester
  • Ether
  • Household Toxin
  • Indicator and Reagent
  • Organic Compound
  • Synthetic Compound
Not Available
Number of Targets: 12
T3D4710Prednisone
53-03-2
C21H26O5
358.428 g/mol
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  • Anti-Inflammatory Agent
  • Antineoplastic Agent, Hormonal
  • Drug
  • Ester
  • Glucocorticoid
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds w...more
Number of Targets: 4
T3D4711Procarbazine
671-16-9
C12H19N3O
221.299 g/mol
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  • Amide
  • Amine
  • Antineoplastic Agent
  • Drug
  • Ester
  • Hydrazine
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthe...more
Number of Targets: 1
T3D4712Propylthiouracil
51-52-5
C7H10N2OS
170.232 g/mol
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  • Amide
  • Antimetabolite
  • Antithyroid Agent
  • Drug
  • Ester
  • Metabolite
  • Organic Compound
  • Synthetic Compound
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrog...more
Number of Targets: 2
T3D4714Tamoxifen
10540-29-1
C26H29NO
371.515 g/mol
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  • Amine
  • Antineoplastic Agent, Hormonal
  • Bone Density Conservation Agent
  • Drug
  • Estrogen Antagonist
  • Ether
  • Metabolite
  • Organic Compound
  • Selective Estrogen Receptor Modulator
  • Synthetic Compound
Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the ...more
Number of Targets: 12
T3D4715Teniposide
29767-20-2
C32H32O13S
656.654 g/mol
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  • Antineoplastic Agent
  • Drug
  • Enzyme Inhibitor
  • Ester
  • Ether
  • Metabolite
  • Nucleic Acid Synthesis Inhibitor
  • Organic Compound
  • Synthetic Compound
The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DN...more
Number of Targets: 1
T3D4716Thiotepa
52-24-4
C6H12N3PS
189.218 g/mol
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  • Drug
  • Metabolite
  • Organic Compound
  • Synthetic Compound
The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. They stop tumor growth by crosslinking guanine nucleobases...more
Number of Targets: 1
T3D4718Uracil mustard
66-75-1
C8H11Cl2N3O2
252.098 g/mol
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  • Amide
  • Amine
  • Drug
  • Metabolite
  • Organic Compound
  • Organochloride
  • Synthetic Compound
After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Number of Targets: 1
T3D4719Zalcitabine
7481-89-2
C9H13N3O3
211.218 g/mol
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  • Amine
  • Anti-HIV Agent
  • Antimetabolite
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Reverse Transcriptase Inhibitor
  • Synthetic Compound
Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is conv...more
Number of Targets: 0
T3D4720Zidovudine
30516-87-1
C10H13N5O4
267.241 g/mol
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  • Amide
  • Anti-HIV Agent
  • Antimetabolite
  • Drug
  • Ether
  • Metabolite
  • Organic Compound
  • Reverse Transcriptase Inhibitor
  • Synthetic Compound
Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5ду_-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It...more
Number of Targets: 1
T3D4725Ozone
10028-15-6
O3
47.998 g/mol
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  • Food Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Lachrymator
  • Metabolite
  • Natural Compound
Ozone is a strong oxidant and reacts directly with organic double bonds. When ozone breaks down to dioxygen it gives rise to oxygen free radicals, which are highly rea...more
Number of Targets: 1
T3D4726Alteplase
105857-23-6
Not Available
62916.495 g/mol
T3d4726
  • Amide
  • Amine
  • Animal Toxin
  • Natural Compound
  • Organic Compound
  • Protein
  • Thrombolytic Agent
Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen ...more
Number of Targets: 4
T3D4727Streptokinase
9002-01-1
Not Available
50139.695 g/mol
T3d4727
  • Amide
  • Amine
  • Bacterial Toxin
  • Fibrinolytic Agent
  • Natural Compound
  • Organic Compound
  • Protein
  • Thrombolytic Agent
Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting ...more
Number of Targets: 2
T3D4729Diclofenac
15307-86-5
C14H11Cl2NO2
296.149 g/mol
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  • Amine
  • Anti-Inflammatory Agent, Non-Steroidal
  • Cyclooxygenase Inhibitor
  • Drug
  • Organic Compound
  • Organochloride
  • Synthetic Compound
The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to ...more
Number of Targets: 8
T3D4730Medroxyprogesterone Acetate
71-58-9
C24H34O4
386.524 g/mol
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  • Antineoplastic Agent, Hormonal
  • Contraceptive Agent
  • Contraceptive Agent, Female
  • Contraceptive Agent, Male
  • Drug
  • Ester
  • Ether
  • Organic Compound
  • Synthetic Compound
Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Onc...more
Number of Targets: 2
T3D4731Potassium Chloride
7447-40-7
ClK
74.551 g/mol
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  • Drug
  • Food Toxin
  • Household Toxin
  • Inorganic Compound
  • Natural Compound
Supplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels.
Number of Targets: 6
T3D4732Tacrolimus
104987-11-3
C44H69NO12
804.018 g/mol
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  • Amide
  • Amine
  • Drug
  • Ester
  • Ether
  • Organic Compound
  • Synthetic Compound
The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in ato...more
Number of Targets: 1
T3D4733Quinapril
85441-61-8
C25H30N2O5
438.516 g/mol
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  • Amide
  • Amine
  • Angiotensin-Converting Enzyme Inhibitor
  • Antihypertensive Agent
  • Drug
  • Ester
  • Ether
  • Organic Compound
  • Synthetic Compound
There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which h...more
Number of Targets: 1
T3D4734Salmeterol
89365-50-4
C25H37NO4
415.566 g/mol
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  • Adrenergic beta-2 Receptor Agonist
  • Amine
  • Bronchodilator Agent
  • Drug
  • Ether
  • Organic Compound
  • Sympathomimetic
  • Synthetic Compound
Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the mol...more
Number of Targets: 1
T3D4735Salbutamol
18559-94-9
C13H21NO3
239.311 g/mol
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  • Adrenergic beta-2 Receptor Agonist
  • Amine
  • Bronchodilator Agent
  • Drug
  • Food Toxin
  • Organic Compound
  • Synthetic Compound
  • Tocolytic Agent
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relax...more
Number of Targets: 2
T3D4736Fludarabine
75607-67-9
C10H13FN5O7P
365.212 g/mol
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  • Amine
  • Antineoplastic Agent
  • Drug
  • Ether
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluor...more
Number of Targets: 4
T3D4737Amiodarone
1951-25-3
C25H29I2NO3
645.312 g/mol
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  • Amine
  • Anti-Arrhythmia Agent
  • Drug
  • Enzyme Inhibitor
  • Ester
  • Ether
  • Organic Compound
  • Synthetic Compound
  • Vasodilator Agent
The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3) duration and refractory pe...more
Number of Targets: 4
Displaying toxin 3401 - 3425 of 3678 in total