Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4366 | L-Phenylalanine 63-91-2 | C9H11NO2 165.189 g/mol |  |
| Extremely high serum levels of phenylalanine are found in patients with the inborn error of metabolism (IEM) called Phenylketonuria (PKU). At pathological concentratio...more Number of Targets: 10 |
| T3D0302 | Arsenocholine 39895-81-3 | C5H14AsO 165.085 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4258 | 2-Hydroxyadipic acid 18294-85-4 | C6H10O5 162.141 g/mol |  |
| 2-Hydroxyadipic acid is a hydroxy-dicarboxylic acid formed by the reduction of 2-ketoadipic acid. Deficiency of 2-ketoadipic dehydrogenase causes 2-ketoadipic acidemia...more Number of Targets: 0 |
| T3D4262 | 3-Hydroxymethylglutaric acid 503-49-1 | C6H10O5 162.141 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4259 | Aminoadipic acid 542-32-5 | C6H11NO4 161.156 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D4257 | Oxoadipic acid 3184-35-8 | C6H8O5 160.125 g/mol |  |
| In the matrix of mitochondria, 2-oxoadipate is decarboxylated to glutaryl-CoA by the 2-oxoadipate dehydrogenase complex and then converted to acetyl-CoA. Accumulation ...more Number of Targets: 1 |
| T3D4471 | Succinylacetone 51568-18-4 | C7H10O4 158.152 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4936 | Allantoin 97-59-6 | C4H6N4O3 158.115 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4292 | Orotic acid 65-86-1 | C5H4N2O4 156.096 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4363 | L-Histidine 71-00-1 | C6H9N3O2 155.155 g/mol |  |
| Since the actions of supplemental L-histidine are unclear, any postulated mechanism is entirely speculative. However, some facts are known about L-histidine and some o...more Number of Targets: 5 |
| T3D4300 | Dopamine 51-61-6 | C8H11NO2 153.178 g/mol |  |
| Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces posi...more Number of Targets: 15 |
| T3D4409 | Xanthine 69-89-6 | C5H4N4O2 152.111 g/mol |  |
| Xanthine is a poorly soluble compound. As a result high concentrations of serum xanthine can lead to the formation of kidney stones (xanthine kidney stones) which can...more Number of Targets: 0 |
| T3D4868 | 2,6-Diethylaniline 579-66-8 | C10H15N 149.233 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4328 | L-Methionine 63-68-3 | C5H11NO2S 149.211 g/mol |  |
| The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the live...more Number of Targets: 5 |
| T3D4247 | L-2-Hydroxyglutaric acid 13095-48-2 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4251 | D-2-Hydroxyglutaric acid 2889-31-8 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4357 | 3-Hydroxyglutaric acid 638-18-6 | C5H8O5 148.114 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4296 | L-Glutamic acid 56-86-0 | C5H9NO4 147.129 g/mol |  |
| Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid ...more Number of Targets: 76 |
| T3D4319 | L-Glutamine 56-85-9 | C5H10N2O3 146.145 g/mol |  |
| Supplemental L-glutamine's possible immunomodulatory role may be accounted for in a number of ways. L-glutamine appears to play a major role in protecting the integrit...more Number of Targets: 3 |
| T3D4594 | Caprylic acid 124-07-2 | C8H16O2 144.211 g/mol |  |
| It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more Number of Targets: 0 |
| T3D3968 | 1-Naphthol 90-15-3 | C10H8O 144.170 g/mol |  |
| 1-Naphthol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 5 |
| T3D4265 | 3-Methylglutaconic acid 5746-90-7 | C6H8O4 144.125 g/mol |  |
| Accumulation of 3-methylglutaconic acid in the body has been shown to be toxic. 3-methylglutaconyl-CoA hydratase is involved in the metabolism process of 3-methylgluta...more Number of Targets: 0 |
| T3D4435 | Tyramine 51-67-2 | C8H11NO 137.179 g/mol |  |
| Tyramine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 4 |
| T3D4279 | Adenine 73-24-5 | C5H5N5 135.127 g/mol |  |
| Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotid...more Number of Targets: 10 |
| T3D4362 | L-Asparagine 70-47-3 | C4H8N2O3 132.118 g/mol |  |
| Asparagine, a non-essential amino acid is important in the metabolism of toxic ammonia in the body through the action of asparagine synthase which attaches ammonia to ...more Number of Targets: 6 |