Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4404 | Methylmalonic acid 516-05-2 | C4H6O4 118.088 g/mol |  |
| Methylmalonic acid is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This me...more Number of Targets: 0 |
| T3D0303 | Methylarsine 593-52-2 | CH5As 91.972 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D2624 | Melittin (Apis mellifera) 20449-79-0 | Not Available 7584.775 g/mol |  |
| Melittin has strong haemolytic activity. It integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged p...more Number of Targets: 12 |
| T3D2972 | Melatonin 73-31-4 | C13H16N2O2 232.278 g/mol |  |
| Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction ...more Number of Targets: 18 |
| T3D2521 | Maurotoxin 188240-41-7 | Not Available 3621.205 g/mol |  |
| Maurotoxin acts by blocking several types of voltage-gated potassium channel. (L1059) Number of Targets: 7 |
| T3D2582 | Maurocalcin 269745-22-4 | Not Available 3864.570 g/mol |  |
| Maurocalcin potently and reversibly modifies channel gating behaviour of the type 1 ryanodine receptor by inducing prominent subconductance behaviour. (T170) Number of Targets: 1 |
| T3D2580 | Mastoparan (Vespa tropica) 72093-21-1 | Not Available 1625.055 g/mol |  |
| Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the rele...more Number of Targets: 0 |
| T3D2536 | Marinobufagenin 470-42-8 | C24H32O5 400.508 g/mol |  |
| Marinobufagin blocks the sodium/potassium pump in heart tissue. (L1084, L1085) Number of Targets: 0 |
| T3D2520 | Margatoxin 145808-47-5 | Not Available 4184.990 g/mol |  |
| Margatoxin blocks potassium channels, resulting in a loss of outward current and affecting neurotransmitter release. (L1057) Number of Targets: 1 |
| T3D4519 | Malaoxon 1634-78-2 | C10H19O7PS 314.292 g/mol |  |
| Malaoxon is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 9 |
| T3D2587 | Maitotoxin 59392-53-9 | C164H256Na2O68S2 3425.856 g/mol |  |
| Maitotoxin activates calcium permeable, non-selective cation channels, leading to an increase in levels of cytosolic calcium ions. It is thought that maitotoxin leads ...more Number of Targets: 0 |
| T3D2625 | Lopap Not Available | Not Available 22432.280 g/mol |  |
| Lopap activates thrombin by cleavage of prothrombin, causing thrombus formation, fibrinogen depletion, uncoagulable blood, decreased platelet count, inhibition of coll...more Number of Targets: 0 |
| T3D4963 | Lithocholic acid 434-13-9 | C24H40O3 376.573 g/mol |  |
| Not Available Number of Targets: 11 |
| T3D4759 | Liothyronine 6893-02-3 | C15H12I3NO4 650.974 g/mol |  |
| The hormones, T4 and T3, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid horm...more Number of Targets: 10 |
| T3D4370 | L-Valine 72-18-4 | C5H11NO2 117.146 g/mol |  |
| (Applies to Valine, Leucine and Isoleucine) This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of ca...more Number of Targets: 3 |
| T3D4371 | L-Tyrosine 60-18-4 | C9H11NO3 181.189 g/mol |  |
| Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the...more Number of Targets: 5 |
| T3D4369 | L-Tryptophan 73-22-3 | C11H12N2O2 204.225 g/mol |  |
| A number of important side reactions occur during the catabolism of tryptophan on the pathway to acetoacetate. The first enzyme of the catabolic pathway is an iron por...more Number of Targets: 7 |
| T3D4368 | L-Threonine 72-19-5 | C4H9NO3 119.119 g/mol |  |
| L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver. May help combat mental illness and ...more Number of Targets: 3 |
| T3D4367 | L-Serine 56-45-1 | C3H7NO3 105.093 g/mol |  |
| L-Serine plays a role in cell growth and development (cellular proliferation). The conversion of L-serine to glycine by serine hydroxymethyltransferase results in the ...more Number of Targets: 8 |
| T3D4411 | L-Proline 147-85-3 | C5H9NO2 115.131 g/mol |  |
| Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline v...more Number of Targets: 23 |
| T3D4366 | L-Phenylalanine 63-91-2 | C9H11NO2 165.189 g/mol |  |
| Extremely high serum levels of phenylalanine are found in patients with the inborn error of metabolism (IEM) called Phenylketonuria (PKU). At pathological concentratio...more Number of Targets: 10 |
| T3D4328 | L-Methionine 63-68-3 | C5H11NO2S 149.211 g/mol |  |
| The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the live...more Number of Targets: 5 |
| T3D4365 | L-Leucine 61-90-5 | C6H13NO2 131.173 g/mol |  |
| This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of carbon atoms cannot be made by humans, these a...more Number of Targets: 10 |
| T3D4253 | L-Lactic acid 79-33-4 | C3H6O3 90.078 g/mol |  |
| Accumulation of L-lactic acid in the body has been shown to be toxic. At times of lactic acidosis, when excess intracellular lactate is released into the blood, mainte...more Number of Targets: 1 |
| T3D4364 | L-Isoleucine 73-32-5 | C6H13NO2 131.173 g/mol |  |
| (Applies to Valine, Leucine and Isoleucine) This group of essential amino acids are identified as the branched-chain amino acids, BCAAs. Because this arrangement of ca...more Number of Targets: 6 |