Browsing Toxin Types
Vasoconstrictor Agent (13)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2460 | Ergotamine | 113-15-5 | Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agon...more |
| T3D2726 | Methysergide | 361-37-5 | Ergoline alkaloids have been shown to have the significant affinity towards the 5-HT1 and 5-HT2 s...more |
| T3D2748 | Zolmitriptan | 139264-17-8 | Zolmitriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blo...more |
| T3D2750 | Dihydroergotamine | 6190-39-2 | Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: ...more |
| T3D2856 | Sumatriptan | 103628-46-2 | The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin ...more |
| T3D2927 | Cocaine | 50-36-2 | Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction i...more |
| T3D2931 | Almotriptan | 181183-52-8 | Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial bloo...more |
| T3D2939 | Naratriptan | 121679-13-8 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D2940 | Rizatriptan | 145202-66-0 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D2954 | Frovatriptan | 158747-02-5 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D3040 | Ephedrine | 299-42-3 | Ephedrine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibito...more |
| T3D3686 | Methylergonovine | 113-42-8 | Ergoline alkaloids have been shown to have the significant affinity towards the 5-HT1 and 5-HT2 s...more |
| T3D4154 | Norepinephrine | 51-41-2 | Uremic toxins such as noradrenalin are actively transported into the kidneys via organic ion tran...more |
Vasodilator Agent (7)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2758 | Diltiazem | 42399-41-7 | Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering w...more |
| T3D2841 | Nicotinic acid | 59-67-6 | Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic ac...more |
| T3D2975 | Perhexiline | 6621-47-2 | Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. I...more |
| T3D3544 | Verapamil | 52-53-9 | Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium...more |
| T3D4275 | Adenosine | 58-61-7 | Adenosine slows conduction time through the AV node and can interrupt the reentry pathways throug...more |
| T3D4737 | Amiodarone | 1951-25-3 | The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the...more |
| T3D4780 | Theophylline | 58-55-9 | Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and r...more |
Vitamin (13)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D0673 | Cyanocobalamin | 68-19-9 | Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The ...more |
| T3D2692 | Calcitriol | 32222-06-3 | The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their ant...more |
| T3D2694 | Calcidiol | 19356-17-3 | Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitrio...more |
| T3D2696 | Thiamine | 59-43-8 | It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduc...more |
| T3D2697 | Ergocalciferol | 50-14-6 | Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vit...more |
| T3D2699 | Vitamin A | 68-26-8 | Vision:Vitamin A (all-trans retinol) is converted in the retina to the 11-cis-isomer of retinalde...more |
| T3D2700 | Alpha-Tocopherol | 59-02-9 | Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant ac...more |
| T3D2701 | Pyridoxine | 65-23-6 | Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyrido...more |
| T3D2703 | Cholecalciferol | 67-97-0 | The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed ...more |
| T3D2704 | Menadione | 58-27-5 | Menadione (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of ...more |
| T3D2849 | Pteroyl-D-glutamic acid | 1492-18-8 | As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid unde...more |
| T3D2959 | Phytonadione | 84-80-0 | Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttrans...more |
| T3D2974 | Dihydrotachysterol | 67-96-9 | Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D recep...more |
Vitamin A (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2699 | Vitamin A | 68-26-8 | Vision:Vitamin A (all-trans retinol) is converted in the retina to the 11-cis-isomer of retinalde...more |
Vitamin B Complex (12)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D0673 | Cyanocobalamin | 68-19-9 | Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The ...more |
| T3D0677 | Hydroxocobalamin | 13422-51-0 | Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobal...more |
| T3D2690 | Biotin | 58-85-5 | Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix c...more |
| T3D2696 | Thiamine | 59-43-8 | It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduc...more |
| T3D2698 | Folic acid | 59-30-3 | Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetra...more |
| T3D2701 | Pyridoxine | 65-23-6 | Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyrido...more |
| T3D2702 | (R)-lipoic acid | 62-46-4 | (R)-lipoic acid is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase in...more |
| T3D2832 | L-Carnitine | 541-15-1 | Levocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitam...more |
| T3D2841 | Nicotinic acid | 59-67-6 | Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic ac...more |
| T3D2849 | Pteroyl-D-glutamic acid | 1492-18-8 | As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid unde...more |
| T3D4407 | Pyridoxal 5'-phosphate | 54-47-7 | Pyridoxal Phosphate is a coenzyme of many enzymatic reactions. It is the active form of vitamin B...more |
| T3D4817 | Riboflavin | 83-88-5 | Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the pr...more |
Vitamin D (5)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2692 | Calcitriol | 32222-06-3 | The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their ant...more |
| T3D2694 | Calcidiol | 19356-17-3 | Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitrio...more |
| T3D2697 | Ergocalciferol | 50-14-6 | Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vit...more |
| T3D2703 | Cholecalciferol | 67-97-0 | The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed ...more |
| T3D2974 | Dihydrotachysterol | 67-96-9 | Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D recep...more |
Vitamin D3 Receptor inhibitor (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D3062 | Calcipotriol | 112965-21-6 | The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it ...more |
Vitamin K (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2959 | Phytonadione | 84-80-0 | Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttrans...more |
Vitamin K Antagonist (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D3735 | Dicumarol | 66-76-2 | Dicoumarol is an anticoagulant that competitively inhibits vitamin K, preventing the formation of...more |
Volatile Isocyanate (5)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D1661 | Hexamethylene diisocyanate | 822-06-0 | Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport c...more |
| T3D1664 | Methylene diphenyl diisocyanate | 101-68-8 | Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport c...more |
| T3D1665 | Toluene diisocyanate | 86-91-9 | Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport c...more |
| T3D1667 | 2,4-Toluene diisocyanate | 584-84-9 | 2,4-Toluene diisocyanate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholines...more |
| T3D1668 | 2,6-Toluene diisocyanate | 91-08-7 | Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport c...more |