Browsing Toxin Types
Anti-Dyskinesia Agent (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2984 | Pimozide | 2062-78-4 | The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be...more |
Anti-HIV Agent (5)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2863 | Amprenavir | 161814-49-9 | Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polypr...more |
| T3D4719 | Zalcitabine | 7481-89-2 | Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Im...more |
| T3D4720 | Zidovudine | 30516-87-1 | Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its act...more |
| T3D4772 | Stavudine | 3056-17-5 | Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the na...more |
| T3D4786 | Didanosine | 69655-05-6 | Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moi...more |
Anti-Infective Agent (9)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2482 | Dapsone | 80-08-0 | Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibitin...more |
| T3D2675 | Linezolid | 165800-03-3 | Linezolid targets the large 39S subunit of the mitochondrial ribosome thereby deactivation mitoch...more |
| T3D2679 | Nitrofurantoin | 67-20-9 | Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced r...more |
| T3D2892 | Sulfasalazine | 599-79-1 | The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapy...more |
| T3D2968 | Gatifloxacin | 112811-59-3 | The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (...more |
| T3D3495 | Ciprofloxacin | 85721-33-1 | The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II ...more |
| T3D4703 | Metronidazole | 443-48-1 | Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to th...more |
| T3D4752 | Nitrofural | 59-87-0 | The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, espec...more |
| T3D4816 | Salicylic acid | 69-72-7 | Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases ...more |
Anti-Infective Agent, Local (5)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D0182 | Phenol | 108-95-2 | Phenol is irritating and corrosive at high concentrations. Phenol impairs the stratum corneum and...more |
| T3D0770 | Ethanol | 64-17-5 | Alcohol binds to the GABA(A) receptors (delta subunit), NMDA receptors, Glycine receptors, Seroto...more |
| T3D2729 | Clotrimazole | 23593-75-1 | Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanos...more |
| T3D3068 | Silver sulfadiazine | 22199-08-2 | Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemica...more |
| T3D4821 | Gentian Violet | 14426-25-6 | Gentian Violet is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inh...more |
Anti-Infective Agent, Urinary (2)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2478 | Levofloxacin | 100986-85-4 | Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levoflox...more |
| T3D2679 | Nitrofurantoin | 67-20-9 | Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to active reduced r...more |
Anti-Inflammatory Agent (14)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2482 | Dapsone | 80-08-0 | Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibitin...more |
| T3D2665 | Pamidronate | 40391-99-9 | The mechanism of action of pamidronate is inhibition of bone resorption. Pamidronate adsorbs to c...more |
| T3D2696 | Thiamine | 59-43-8 | It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduc...more |
| T3D2701 | Pyridoxine | 65-23-6 | Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyrido...more |
| T3D2748 | Zolmitriptan | 139264-17-8 | Zolmitriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blo...more |
| T3D2753 | Indomethacin | 53-86-1 | Antiinflammatory effects of Indomethacin are believed to be due to inhibition of cylooxygenase in...more |
| T3D2866 | Flurbiprofen | 5104-49-4 | Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhib...more |
| T3D2931 | Almotriptan | 181183-52-8 | Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial bloo...more |
| T3D2940 | Rizatriptan | 145202-66-0 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D2954 | Frovatriptan | 158747-02-5 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D2970 | Ibuprofen | 15687-27-1 | The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of ...more |
| T3D4710 | Prednisone | 53-03-2 | Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its acti...more |
| T3D4756 | Triamcinolone | 124-94-7 | The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase...more |
| T3D4982 | Dexamethasone | 50-02-2 | Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds...more |
Anti-Inflammatory Agent, Non-Steroidal (12)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2753 | Indomethacin | 53-86-1 | Antiinflammatory effects of Indomethacin are believed to be due to inhibition of cylooxygenase in...more |
| T3D2866 | Flurbiprofen | 5104-49-4 | Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhib...more |
| T3D2886 | Olopatadine | 113806-05-6 | Olopatadine is a selective histamine H1 antagonist that binds to the histamine H1 receptor. This ...more |
| T3D2892 | Sulfasalazine | 599-79-1 | The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapy...more |
| T3D2899 | Meloxicam | 71125-38-7 | Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synt...more |
| T3D2918 | Diflunisal | 22494-42-4 | The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. ...more |
| T3D2936 | Aspirin | 50-78-2 | The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to acti...more |
| T3D2957 | Balsalazide | 80573-04-2 | The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammat...more |
| T3D2970 | Ibuprofen | 15687-27-1 | The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of ...more |
| T3D3514 | Infliximab | 170277-31-3 | Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the solub...more |
| T3D4673 | Adapalene | 106685-40-9 | Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and...more |
| T3D4729 | Diclofenac | 15307-86-5 | The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte...more |
Anti-Menopausal Agent (2)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D4668 | Estradiol | 50-28-2 | Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and ...more |
| T3D4746 | Estrone | 53-16-7 | Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pitui...more |
Anti-Migraine Agent (5)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2748 | Zolmitriptan | 139264-17-8 | Zolmitriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial blo...more |
| T3D2750 | Dihydroergotamine | 6190-39-2 | Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: ...more |
| T3D2931 | Almotriptan | 181183-52-8 | Almotriptan binds with high affinity to human 5-HT1B and 5-HT1D receptors leading to cranial bloo...more |
| T3D2940 | Rizatriptan | 145202-66-0 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
| T3D2954 | Frovatriptan | 158747-02-5 | Three distinct pharmacological actions have been implicated in the antimigraine effect of the tri...more |
Anti-Obesity Agent (2)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2733 | Topiramate | 97240-79-4 | The precise mechanism of action of topiramate is not known. However, studies have shown that topi...more |
| T3D3014 | Dexfenfluramine | 3239-44-9 | Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake...more |