Browsing Toxin Types
Antidote (2)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2799 | Picrotoxin | 124-87-8 | Picrotoxin antagonizes the GABAA receptor channel directly, which is a ligand-gated ion channel c...more |
| T3D2849 | Pteroyl-D-glutamic acid | 1492-18-8 | As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid unde...more |
Antidyskinetic (20)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2576 | Haloperidol | 52-86-8 | The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, b...more |
| T3D2724 | Benzatropine | 86-13-5 | Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discrim...more |
| T3D2731 | Ropinirole | 91374-21-9 | Ropinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ro...more |
| T3D2751 | Tolcapone | 134308-13-7 | Tolcapone hepatoxicity can be attributed to elevated levels of transminases, but studies have sho...more |
| T3D2770 | Trihexyphenidyl | 144-11-6 | Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to dis...more |
| T3D2773 | Procyclidine | 77-37-2 | The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central chol...more |
| T3D2783 | Pramipexole | 104632-26-0 | The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown,...more |
| T3D2808 | Entacapone | 130929-57-6 | The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in pe...more |
| T3D2867 | Apomorphine | 41372-20-7 | The precise mechanism of action of apomorphine as a treatment for Parkinson's disease is unknown,...more |
| T3D2897 | Biperiden | 514-65-8 | Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhi...more |
| T3D2908 | Progabide | 62666-20-0 | Progabide binds to both GABAA and GABAB receptors located on the terminals of primary afferent fi...more |
| T3D2965 | Selegiline | 14611-51-9 | Although the mechanisms for selegiline's beneficial action in the treatment of Parkinson's diseas...more |
| T3D2967 | Memantine | 19982-08-2 | Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentiall...more |
| T3D2976 | Diphenhydramine | 58-73-1 | Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes t...more |
| T3D2984 | Pimozide | 2062-78-4 | The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be...more |
| T3D3005 | Orphenadrine | 83-98-7 | Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the m...more |
| T3D3011 | Pergolide | 66104-22-1 | The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi prote...more |
| T3D3017 | Bromocriptine | 25614-03-3 | The dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi prote...more |
| T3D3028 | L-Dopa | 59-92-7 | Striatal dopamine levels in symptomatic Parkinson's disease are decreased by 60 to 80%, striatal ...more |
| T3D4856 | Diphenhydramine | Not Available | Diphenhydramine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase in...more |
Antidystonic Agent (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D3583 | Botulinum toxin | 93384-43-1 | Botulinum toxin is a two-chain polypeptide with a 100-kDa heavy chain joined by a disulfide bond ...more |
Antiemetic (20)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2565 | Promazine | 58-40-2 | Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C...more |
| T3D2576 | Haloperidol | 52-86-8 | The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, b...more |
| T3D2707 | Lorazepam | 846-49-1 | Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic recept...more |
| T3D2754 | Olanzapine | 132539-06-1 | Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors ...more |
| T3D2789 | Prochlorperazine | 58-38-8 | The mechanism of action of prochlorperazine has not been fully determined, but may be primarily r...more |
| T3D2801 | delta9-Tetrahydrocannabinol | 1972-08-3 | The mechanism of action of marinol is not completely understood. It is thought that cannabinoid r...more |
| T3D2806 | Chlorpromazine | 50-53-3 | Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on do...more |
| T3D2813 | Triflupromazine | 146-54-3 | Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. T...more |
| T3D2874 | Meclizine | 569-65-3 | Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic...more |
| T3D2888 | Propiomazine | 362-29-8 | Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor ...more |
| T3D2899 | Meloxicam | 71125-38-7 | Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synt...more |
| T3D2900 | Propofol | 2078-54-8 | The action of propofol involves a positive modulation of the inhibitory function of the neurotran...more |
| T3D2903 | Diazepam | 439-14-5 | Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects mus...more |
| T3D2905 | Trifluoperazine | 117-89-5 | Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; dep...more |
| T3D2925 | Ondansetron | 99614-02-5 | Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the dr...more |
| T3D2976 | Diphenhydramine | 58-73-1 | Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes t...more |
| T3D4551 | Doxylamine | 469-21-6 | Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors....more |
| T3D4559 | Dimenhydrinate | 523-87-5 | The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and anti...more |
| T3D4856 | Diphenhydramine | Not Available | Diphenhydramine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase in...more |
| T3D4982 | Dexamethasone | 50-02-2 | Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds...more |
Antiendometriotic Agent (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2855 | Nafarelin | 76932-56-4 | Like GnRH, initial or intermittent administration of nafarelin stimulates release of the gonadotr...more |
Antiepileptic Agent (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2937 | Felbamate | 25451-15-4 | The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal tes...more |
Antifibrinolytic Agent (2)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2704 | Menadione | 58-27-5 | Menadione (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of ...more |
| T3D2959 | Phytonadione | 84-80-0 | Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttrans...more |
Antifungal Agent (24)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D1820 | Selenium Sulfide | 7446-34-6 | Selenium sulfide can be decomposed to selenium ions. Selenium readily substitutes for sulfur in b...more |
| T3D2711 | Fluconazole | 86386-73-4 | Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanos...more |
| T3D2722 | Oxiconazole | 64211-46-7 | Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrit...more |
| T3D2729 | Clotrimazole | 23593-75-1 | Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanos...more |
| T3D2763 | Anidulafungin | 166663-25-8 | Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits g...more |
| T3D2847 | Nystatin | 1400-61-9 | Nystatin interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion ...more |
| T3D2921 | Sirolimus | 53123-88-9 | Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic...more |
| T3D2956 | Tioconazole | 65899-73-2 | Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol t...more |
| T3D2961 | Ketoconazole | 65277-42-1 | Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the convers...more |
| T3D2964 | Cerulenin | 17397-89-6 | Irreversibly binds to fatty acid synthase, specifically b-ketoacyl-acyl carrier protein synthase ...more |
| T3D2983 | Flucytosine | 2022-85-7 | Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly...more |
| T3D2988 | Miconazole | 22916-47-8 | Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanost...more |
| T3D2992 | Econazole | 27220-47-9 | Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanoste...more |
| T3D2997 | Sertaconazole | 99592-32-2 | Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lan...more |
| T3D3000 | Trimetrexate | 52128-35-5 | In vitro studies have shown that trimetrexate is a competitive inhibitor of dihydrofolate reducta...more |
| T3D3012 | Ciclopirox | 29342-05-0 | Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopiro...more |
| T3D3035 | Posaconazole | 171228-49-2 | As a triazole antifungal agent, posaconazole exerts its antifungal activity through blockage of t...more |
| T3D3233 | CE(10:0) | 1183-04-6 | Not Available |
| T3D3498 | Cyclosporin | 59865-13-3 | Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally respon...more |
| T3D3516 | Itraconazole | 84625-61-6 | Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lano...more |
| T3D3526 | Pentamidine | 100-33-4 | The mode of action of pentamidine is not fully understood. It is thought that the drug interferes...more |
| T3D4696 | Griseofulvin | 126-07-8 | Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of derma...more |
| T3D4773 | Capric acid | 334-48-5 | It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pat...more |
| T3D4816 | Salicylic acid | 69-72-7 | Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases ...more |
Antihistamine Derivative (1)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2790 | Cyproheptadine | 129-03-3 | Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes th...more |
Antihypertensive Agent (11)
| T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
|---|---|---|---|
| T3D2713 | Reserpine | 50-55-5 | Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the se...more |
| T3D2758 | Diltiazem | 42399-41-7 | Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering w...more |
| T3D2825 | Benzthiazide | 91-33-8 | As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via ...more |
| T3D2829 | Clonidine | 4205-90-7 | Clonidine acts as an agonist at presynaptic alpha(2)-receptors in the nucleus tractus solitarius ...more |
| T3D3478 | Methyldopa | 555-29-3 | Although the mechanism of action has yet to be conclusively demonstrated, the antihypertensive ef...more |
| T3D3480 | Atenolol | 29122-68-7 | Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines ...more |
| T3D3487 | Brimonidine | 59803-98-4 | Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hyp...more |
| T3D3517 | Labetalol | 36894-69-6 | Labetalol has two asymmetric centers and therefore, exists as a molecular complex of two diastere...more |
| T3D3577 | Methyldopa | 555-30-6 | Although the mechanism of action has yet to be conclusively demonstrated, the resultant hypotensi...more |
| T3D4733 | Quinapril | 85441-61-8 | There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a...more |
| T3D4781 | Hydrochlorothiazide | 58-93-5 | Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibitin...more |