Displaying types 101 - 110 of 483 in total

Antihypocalcemic Agent (11)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2663Clodronate10596-23-3The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the sp...more
T3D2666Alendronic acid66376-36-1The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more
T3D2667Ibandronate114084-78-5The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more
T3D2668Risedronate105462-24-6The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more
T3D2669Zoledronate118072-93-8The action of zoledronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more
T3D2692Calcitriol32222-06-3The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their ant...more
T3D2694Calcidiol19356-17-3Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitrio...more
T3D2697Ergocalciferol50-14-6Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vit...more
T3D2703Cholecalciferol67-97-0The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed ...more
T3D2974Dihydrotachysterol67-96-9Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D recep...more
T3D3483Etidronic acid7414-83-7Bisphosphonates, when attached to bone tissue, are absorbed by osteoclasts, the bone cells that b...more

Antihypoparathyroid Agent (5)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2692Calcitriol32222-06-3The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their ant...more
T3D2694Calcidiol19356-17-3Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitrio...more
T3D2697Ergocalciferol50-14-6Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vit...more
T3D2703Cholecalciferol67-97-0The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed ...more
T3D2974Dihydrotachysterol67-96-9Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D recep...more

Antilipemic Agent (1)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2841Nicotinic acid59-67-6Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic ac...more

Antimalarial (7)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2482Dapsone80-08-0Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibitin...more
T3D2561Chloroquine54-05-7The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinol...more
T3D2800Quinine130-95-0The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs...more
T3D3501Docetaxel114977-28-5Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicin...more
T3D3512Hydroxychloroquine118-42-3Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroqui...more
T3D3950Doxycycline564-25-0Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mit...more
T3D4779Pyrimethamine58-14-0Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthes...more

Antimanic Agent (5)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2558Valproic acid99-66-1Valproic Acid binds to and inhibits GABA transaminase. This leads to increased brain concentratio...more
T3D2570Lamotrigine84057-84-1One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established...more
T3D2814Divalproex sodium76584-70-8Divalproex binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be rel...more
T3D2826Carbamazepine298-46-4Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pai...more
T3D2952Gabapentin60142-96-3Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium cha...more

Antimetabolite (12)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2486Methotrexate59-05-2Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading t...more
T3D2738Bleomycin11056-06-7It has been suggested that bleomycin induces sensitivity to oxygen toxicity and recent studies su...more
T3D2983Flucytosine2022-85-7Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly...more
T3D3477Allopurinol315-30-0Allopurinol inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypox...more
T3D3507Capecitabine154361-50-9Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluoroura...more
T3D4677Azathioprine446-86-6Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. I...more
T3D4712Propylthiouracil51-52-5Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iod...more
T3D4719Zalcitabine7481-89-2Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Im...more
T3D4720Zidovudine30516-87-1Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its act...more
T3D4772Stavudine3056-17-5Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the na...more
T3D4776Fluorouracil51-21-8The precise mechanism of action has not been fully determined, but the main mechanism of fluorour...more
T3D4786Didanosine69655-05-6Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes to its active moi...more

Antimetabolite, Antineoplastic (8)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2486Methotrexate59-05-2Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading t...more
T3D3000Trimetrexate52128-35-5In vitro studies have shown that trimetrexate is a competitive inhibitor of dihydrofolate reducta...more
T3D3507Capecitabine154361-50-9Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluoroura...more
T3D4676Azacitidine320-67-2Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA...more
T3D4677Azathioprine446-86-6Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. I...more
T3D4770Tioguanine154-42-7Thioguanine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphorib...more
T3D4776Fluorouracil51-21-8The precise mechanism of action has not been fully determined, but the main mechanism of fluorour...more
T3D4978Cytarabine147-94-4Cytarabine acts through direct DNA damage and incorporation into DNA. Cytarabine is cytotoxic to ...more

Antimitotic Agent (1)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D4617Podofilox477-47-4Etoposide, a semisynthetic derivative of podofilox, induces DNA breakage through its inhibition o...more

Antimony Compound (58)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D0219Antimony7440-36-0The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D0721Zinc antimonide12039-35-9Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, mos...more
T3D0871Antimony pentasulfide1315-04-4The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0872Antimony pentoxide1314-60-9The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0873Antimony potassium tartrate28300-74-5The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0874Antimony trichloride10025-91-9The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0875Antimony trioxide1309-64-4The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0876Antimony trisulfide1345-04-6The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0877Stibine7803-52-3The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D0878Antimony pentachloride7647-18-9The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1491Aluminium antimonide25152-52-7The main target organs of aluminum are the central nervous system and bone. Aluminum binds with d...more
T3D1722Antimony tribromide7789-61-9Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water ...more
T3D1829Antimony triselenide1315-05-5Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especi...more
T3D1859Antimony monosulfide12067-17-3The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1860Antimony tetramer12597-17-0The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1861Antimony(III) isopropoxide18770-47-3The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1862Antimony(III) ethoxide10433-06-4The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1863Chlorofluorotrimethylantimony13077-54-8The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1864Chlorohydroxytriphenylantimony36368-97-5The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible ...more
T3D1866Diantimony diselenide193095-46-4The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1867Diantimony tetrasulfide12359-48-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1868Dibromotributylantimony16629-56-4The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1869Dichlorotribenzylantimony19493-17-5The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1870Dioxygenyl hexafluoroantimonate12361-66-9The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1872Hexafluoroantimonic acid16950-06-4The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1873Lithium hexafluoroantimonate(V)18424-17-4The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1874Magic acid (fluorosulfuric acid-antimony pentafluoride)23854-38-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1875Nitronium hexafluoroantimonate(V)17856-92-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1876Nitrosonium (nitrosyl) hexafluoroantimonate16941-06-3The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1877Potassium hexahydroxoantimonate(V)12208-13-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1878Potassium antimonyl tartrate trihydrateNot AvailableThe inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1879Potassium hexafluoroantimonate(V)16893-92-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1880Potassium pyroantimonate10090-54-7 The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1881Silver(I) hexafluoroantimonate26042-64-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1882Sodium hexafluoroantimonate16925-25-0The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1883Sodium thioantimonate(V)13776-84-6The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1884Tetrabutylantimony(V) bromide45212-19-9The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1885Tetraphenylantimony bromide16894-69-2The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1886Triantimony disulfide107373-21-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1887Triethyloxonium hexachloroantimonate3264-67-3The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1888Trimethylantimony bromide5835-64-3The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1889Trimethylantimony dichloride13059-67-1The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1890Trimethylantimony diiodide13077-53-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1891Trimethyloxonium hexachlorantimonate54075-76-2The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1892Triphenylantimony603-36-1The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1893Triphenylantimony diacetate1538-62-1The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1894Triphenylantimony dibenzoate57997-56-5The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1895Triphenylantimony dichloride594-31-0The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1896Triphenylthioantimonate28609-58-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1897Triphenylcarbenium hexachloroantimonate52704-88-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1898Tris(1-naphthyl)antimony27309-70-2The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1899Tris(3-(trifluoromethyl)phenyl)antimony386-91-4The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1900Tris(4-bromophenyl)aminium hexachloroantimonate24964-91-8The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1901Tris(4-bromophenyl)antimony17946-45-1The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1902Tris(dimethylamino)antimony7289-92-1The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1903Tris(o-tolyl)antimony23822-15-3The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1904Tris(p-tolyl)antimony5395-43-7The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more
T3D1905Antimony acetate3643-76-3The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible...more

Antimuscarinic (1)

T3DB IDCommon nameCAS NumberMechanism of Toxicity
T3D2877Scopolamine51-34-3Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the p...more
Displaying types 101 - 110 of 483 in total