Browsing Toxin Types
Displaying types 121 - 130 of 483 in total
Antiperistaltic Agent (1)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2978 | Diphenoxylate | 915-30-0 | Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the pe...more |
Antiprotozoal Agent (8)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D3000 | Trimetrexate | 52128-35-5 | In vitro studies have shown that trimetrexate is a competitive inhibitor of dihydrofolate reducta...more |
T3D3476 | Albendazole | 54965-21-8 | Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by b...more |
T3D3516 | Itraconazole | 84625-61-6 | Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lano...more |
T3D3526 | Pentamidine | 100-33-4 | The mode of action of pentamidine is not fully understood. It is thought that the drug interferes...more |
T3D3952 | Lymecycline | 992-21-2 | Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mit...more |
T3D3955 | Tetracycline | 60-54-8 | Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mit...more |
T3D4703 | Metronidazole | 443-48-1 | Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to th...more |
T3D4779 | Pyrimethamine | 58-14-0 | Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthes...more |
Antipruritic (11)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2790 | Cyproheptadine | 129-03-3 | Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes th...more |
T3D2796 | Loratadine | 79794-75-5 | Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonist...more |
T3D2823 | Hydroxyzine | 68-88-2 | Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface...more |
T3D2925 | Ondansetron | 99614-02-5 | Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the dr...more |
T3D2976 | Diphenhydramine | 58-73-1 | Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes t...more |
T3D2980 | Benzocaine | 94-09-7 | Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreas...more |
T3D2989 | Chlorpheniramine | 132-22-9 | Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histami...more |
T3D2993 | Doxepin | 1668-19-5 | The mechanism of action of doxepin is not completely understood. It is thought that like amitript...more |
T3D3224 | Menthol | 2216-51-5 | Menthol acts as a weak Kappa Opioid Receptor Agonist. |
T3D4560 | Promethazine | 60-87-7 | Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor s...more |
T3D4856 | Diphenhydramine | Not Available | Diphenhydramine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase in...more |
Antipsoriatic Agent (2)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D0182 | Phenol | 108-95-2 | Phenol is irritating and corrosive at high concentrations. Phenol impairs the stratum corneum and...more |
T3D3062 | Calcipotriol | 112965-21-6 | The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it ...more |
Antipsychotic Agent (25)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2555 | Quetiapine | 111974-69-7 | The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknow...more |
T3D2565 | Promazine | 58-40-2 | Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C...more |
T3D2576 | Haloperidol | 52-86-8 | The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, b...more |
T3D2677 | Aripiprazole | 129722-12-9 | Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptor...more |
T3D2713 | Reserpine | 50-55-5 | Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the se...more |
T3D2754 | Olanzapine | 132539-06-1 | Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors ...more |
T3D2764 | Clozapine | 5786-21-0 | The mechanism of action of Clozapine, as with other drugs used to treat schizophrenia, is unknown...more |
T3D2779 | Loxapine | 1977-10-2 | Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action o...more |
T3D2789 | Prochlorperazine | 58-38-8 | The mechanism of action of prochlorperazine has not been fully determined, but may be primarily r...more |
T3D2806 | Chlorpromazine | 50-53-3 | Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on do...more |
T3D2813 | Triflupromazine | 146-54-3 | Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. T...more |
T3D2840 | Fluphenazine | 69-23-8 | Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depres...more |
T3D2858 | Thioridazine | 50-52-2 | Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks...more |
T3D2871 | Risperidone | 106266-06-2 | Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizo...more |
T3D2905 | Trifluoperazine | 117-89-5 | Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; dep...more |
T3D2913 | Perphenazine | 58-39-9 | Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of ...more |
T3D2920 | Flupenthixol | 2709-56-0 | Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not comp...more |
T3D2925 | Ondansetron | 99614-02-5 | Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the dr...more |
T3D2933 | Mesoridazine | 5588-33-0 | Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticul...more |
T3D2966 | Carphenazine | 2622-30-2 | A yellow, powdered, phenothiazine antipsychotic agent used in the treatment of acute or chronic s...more |
T3D2984 | Pimozide | 2062-78-4 | The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be...more |
T3D3009 | Chlormezanone | 80-77-3 | Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA r...more |
T3D3031 | Chlorprothixene | 113-59-7 | Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; dep...more |
T3D3041 | Methotrimeprazine | 60-99-1 | Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors i...more |
T3D3046 | Fencamfamine | 1209-98-9 | Fencamfamine acts as an indirect dopamine agonist. It releases dopamine by a similar mechanism to...more |
Antipyretic (2)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2571 | Acetaminophen | 103-90-2 | Paracetamol toxicity is one of the most common causes of poisoning worldwide. The toxic effects o...more |
T3D2936 | Aspirin | 50-78-2 | The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to acti...more |
Antiresorptive (4)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2666 | Alendronic acid | 66376-36-1 | The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more |
T3D2667 | Ibandronate | 114084-78-5 | The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more |
T3D2668 | Risedronate | 105462-24-6 | The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more |
T3D2669 | Zoledronate | 118072-93-8 | The action of zoledronate on bone tissue is based partly on its affinity for hydroxyapatite, whic...more |
Antirheumatic Agent (10)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D2486 | Methotrexate | 59-05-2 | Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading t...more |
T3D2561 | Chloroquine | 54-05-7 | The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinol...more |
T3D2671 | Rituximab | 174722-31-7 | Binds to the CD20 antigen which is found on mature B lymphocytes. The Fc domain recruits immune e...more |
T3D2892 | Sulfasalazine | 599-79-1 | The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapy...more |
T3D3498 | Cyclosporin | 59865-13-3 | Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally respon...more |
T3D3512 | Hydroxychloroquine | 118-42-3 | Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroqui...more |
T3D3514 | Infliximab | 170277-31-3 | Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the solub...more |
T3D4677 | Azathioprine | 446-86-6 | Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. I...more |
T3D4688 | Cyclophosphamide | 50-18-0 | Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases,...more |
T3D4728 | Cyclophosphamide | Not Available | Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases,...more |
Antiscabies Agent (1)
T3DB ID | Common name | CAS Number | Mechanism of Toxicity |
---|---|---|---|
T3D0032 | gamma-Hexachlorocyclohexane | 58-89-9 | Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by inte...more |